| Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity MR McGill, CD Williams, Y Xie, A Ramachandran, H Jaeschke Toxicology and applied pharmacology 264 (3), 387-394, 2012 | 482 | 2012 |
| Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice A Ramachandran, MR McGill, Y Xie, HM Ni, WX Ding, H Jaeschke Hepatology 58 (6), 2099-2108, 2013 | 283 | 2013 |
| Acetaminophen-induced liver injury: from animal models to humans H Jaeschke, Y Xie, MR McGill Journal of clinical and translational hepatology 2 (3), 153, 2014 | 269 | 2014 |
| Mechanisms of acetaminophen-induced cell death in primary human hepatocytes Y Xie, MR McGill, K Dorko, SC Kumer, TM Schmitt, J Forster, H Jaeschke Toxicology and applied pharmacology 279 (3), 266-274, 2014 | 266 | 2014 |
| Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications MR McGill, M Lebofsky, HRK Norris, MH Slawson, ML Bajt, Y Xie, ... Toxicology and applied pharmacology 269 (3), 240-249, 2013 | 249 | 2013 |
| Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice HM Ni, MR McGill, X Chao, K Du, JA Williams, Y Xie, H Jaeschke, ... Journal of hepatology 65 (2), 354-362, 2016 | 217 | 2016 |
| Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products H Jaeschke, CD Williams, MR McGill, Y Xie, A Ramachandran Food and Chemical Toxicology 55, 279-289, 2013 | 175 | 2013 |
| Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury Y Xie, A Ramachandran, DG Breckenridge, JT Liles, M Lebofsky, ... Toxicology and applied pharmacology 286 (1), 1-9, 2015 | 112 | 2015 |
| Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes Y Xie, MR McGill, K Du, K Dorko, SC Kumer, TM Schmitt, WX Ding, ... Toxicology and applied pharmacology 289 (2), 213-222, 2015 | 99 | 2015 |
| Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice BL Woolbright, F Li, Y Xie, A Farhood, P Fickert, M Trauner, H Jaeschke Toxicology letters 228 (1), 56-66, 2014 | 93 | 2014 |
| Editor’s highlight: metformin protects against acetaminophen hepatotoxicity by attenuation of mitochondrial oxidant stress and dysfunction K Du, A Ramachandran, JL Weemhoff, H Chavan, Y Xie, P Krishnamurthy, ... Toxicological Sciences 154 (2), 214-226, 2016 | 75 | 2016 |
| Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells Y Xie, MR McGill, SF Cook, MR Sharpe, RD Winefield, DG Wilkins, ... Xenobiotica 45 (10), 921-929, 2015 | 75 | 2015 |
| Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity K Du, Y Xie, MR McGill, H Jaeschke Expert opinion on drug metabolism & toxicology 11 (11), 1769-1779, 2015 | 71 | 2015 |
| Dual role of epidermal growth factor receptor in liver injury and regeneration after acetaminophen overdose in mice B Bhushan, H Chavan, P Borude, Y Xie, K Du, MR McGill, M Lebofsky, ... Toxicological Sciences 155 (2), 363-378, 2017 | 69 | 2017 |
| Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity K Du, MR McGill, Y Xie, ML Bajt, H Jaeschke Food and Chemical Toxicology 81, 62-70, 2015 | 66 | 2015 |
| Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation Y Xie, CD Williams, MR McGill, M Lebofsky, A Ramachandran, ... toxicological sciences 131 (1), 325-335, 2013 | 62 | 2013 |
| The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation K Du, CD Williams, MR McGill, Y Xie, A Farhood, M Vinken, H Jaeschke Toxicology and applied pharmacology 273 (3), 484-491, 2013 | 53 | 2013 |
| The immunomodulatory effects of the herbicide propanil on murine macrophage interleukin-6 and tumor necrosis factor-α production YC Xie, R Schafer, JB Barnett Toxicology and applied pharmacology 145 (1), 184-191, 1997 | 33 | 1997 |
| Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses K Du, MR McGill, Y Xie, H Jaeschke Food and Chemical Toxicology 86, 253-261, 2015 | 23 | 2015 |
| The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury MR McGill, K Du, Y Xie, ML Bajt, WX Ding, H Jaeschke Xenobiotica 45 (5), 442-449, 2015 | 23 | 2015 |
Hartmut JaeschkeUniversity Distinguished Professor, University of Kansas Medical CenterVahvistettu sähköpostiosoite verkkotunnuksessa kumc.edu
