| Mutations of the BRAF gene in human cancer H Davies, GR Bignell, C Cox, P Stephens, S Edkins, S Clegg, J Teague, ... Nature 417 (6892), 949-954, 2002 | 13173 | 2002 |
| Challenges to curing primary brain tumours K Aldape, KM Brindle, L Chesler, R Chopra, A Gajjar, MR Gilbert, ... Nature reviews Clinical oncology 16 (8), 509-520, 2019 | 821 | 2019 |
| Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease BS Paugh, C Qu, C Jones, Z Liu, M Adamowicz-Brice, J Zhang, DA Bax, ... Journal of clinical oncology 28 (18), 3061-3068, 2010 | 740 | 2010 |
| Diffuse brainstem glioma in children: critical review of clinical trials D Hargrave, U Bartels, E Bouffet The lancet oncology 7 (3), 241-248, 2006 | 740 | 2006 |
| The advantages of targeted protein degradation over inhibition: an RTK case study GM Burslem, BE Smith, AC Lai, S Jaime-Figueroa, DC McQuaid, ... Cell chemical biology 25 (1), 67-77. e3, 2018 | 624 | 2018 |
| Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma KR Taylor, A Mackay, N Truffaux, YS Butterfield, O Morozova, C Philippe, ... Nature genetics 46 (5), 457-461, 2014 | 527 | 2014 |
| Pediatric high-grade glioma: biologically and clinically in need of new thinking C Jones, MA Karajannis, DTW Jones, MW Kieran, M Monje, SJ Baker, ... Neuro-oncology 19 (2), 153-161, 2017 | 416 | 2017 |
| Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International … LM Hoffman, SEM Veldhuijzen van Zanten, N Colditz, J Baugh, B Chaney, ... Journal of clinical oncology 36 (19), 1963-1972, 2018 | 391 | 2018 |
| Histone H3. 3 mutations drive pediatric glioblastoma through upregulation of MYCN L Bjerke, A Mackay, M Nandhabalan, A Burford, A Jury, S Popov, DA Bax, ... Cancer discovery 3 (5), 512-519, 2013 | 348 | 2013 |
| Visual outcomes in children with neurofibromatosis type 1–associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis MJ Fisher, M Loguidice, DH Gutmann, R Listernick, RE Ferner, NJ Ullrich, ... Neuro-oncology 14 (6), 790-797, 2012 | 341 | 2012 |
| Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy L Al-Olabi, S Polubothu, K Dowsett, KA Andrews, P Stadnik, AP Joseph, ... The Journal of clinical investigation 128 (4), 1496-1508, 2018 | 290 | 2018 |
| Melanoma in congenital melanocytic naevi VA Kinsler, P O'hare, N Bulstrode, JE Calonje, WK Chong, D Hargrave, ... British Journal of Dermatology 176 (5), 1131-1143, 2017 | 260 | 2017 |
| Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma E Bouffet, R Jakacki, S Goldman, D Hargrave, C Hawkins, M Shroff, ... Journal of clinical oncology 30 (12), 1358-1363, 2012 | 246 | 2012 |
| Infant high-grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes M Clarke, A Mackay, B Ismer, JC Pickles, RG Tatevossian, S Newman, ... Cancer discovery 10 (7), 942-963, 2020 | 244 | 2020 |
| Paediatric and adult malignant glioma: close relatives or distant cousins? C Jones, L Perryman, D Hargrave Nature reviews Clinical oncology 9 (7), 400-413, 2012 | 234 | 2012 |
| Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease RM Hill, S Kuijper, JC Lindsey, K Petrie, EC Schwalbe, K Barker, ... Cancer cell 27 (1), 72-84, 2015 | 225 | 2015 |
| Nocturnal oxygen saturation and painful sickle cell crises in children DR Hargrave, A Wade, JPM Evans, DKM Hewes, FJ Kirkham Blood, The Journal of the American Society of Hematology 101 (3), 846-848, 2003 | 210 | 2003 |
| MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase–mediated HOX/stem cell gene signature N Gaspar, L Marshall, L Perryman, DA Bax, SE Little, M Viana-Pereira, ... Cancer research 70 (22), 9243-9252, 2010 | 208 | 2010 |
| Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study DR Hargrave, E Bouffet, U Tabori, A Broniscer, KJ Cohen, JR Hansford, ... Clinical Cancer Research 25 (24), 7303-7311, 2019 | 198 | 2019 |
| Natural history and outcome of optic pathway gliomas in children G Nicolin, P Parkin, D Mabbott, D Hargrave, U Bartels, U Tabori, J Rutka, ... Pediatric blood & cancer 53 (7), 1231-1237, 2009 | 198 | 2009 |