| Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, SM Meng, ... Nature Biomedical Engineering 5 (6), 600-612, 2021 | 239 | 2021 |
| Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires E Miho, A Yermanos, CR Weber, CT Berger, ST Reddy, V Greiff Frontiers in immunology 9, 224, 2018 | 205 | 2018 |
| A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding R Akbar, PA Robert, M Pavlović, JR Jeliazkov, I Snapkov, A Slabodkin, ... Cell Reports 34 (11), 2021 | 187 | 2021 |
| Systems analysis reveals high genetic and antigen-driven predetermination of antibody repertoires throughout B cell development V Greiff, U Menzel, E Miho, C Weber, R Riedel, S Cook, A Valai, T Lopes, ... Cell reports 19 (7), 1467-1478, 2017 | 183 | 2017 |
| Learning the high-dimensional immunogenomic features that predict public and private antibody repertoires V Greiff, CR Weber, J Palme, U Bodenhofer, E Miho, U Menzel, ST Reddy The Journal of Immunology 199 (8), 2985-2997, 2017 | 122 | 2017 |
| In silico proof of principle of machine learning-based antibody design at unconstrained scale R Akbar, PA Robert, CR Weber, M Widrich, R Frank, M Pavlović, ... MAbs 14 (1), 2031482, 2022 | 110 | 2022 |
| Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain JM Taft, CR Weber, B Gao, RA Ehling, J Han, L Frei, SW Metcalfe, ... Cell 185 (21), 4008-4022. e14, 2022 | 95 | 2022 |
| High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis DM Mason, CR Weber, C Parola, SM Meng, V Greiff, WJ Kelton, ... Nucleic acids research 46 (14), 7436-7449, 2018 | 91 | 2018 |
| The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires M Pavlović, L Scheffer, K Motwani, C Kanduri, R Kompova, N Vazov, ... Nature Machine Intelligence 3 (11), 936-944, 2021 | 74 | 2021 |
| immuneSIM: tunable multi-feature simulation of B-and T-cell receptor repertoires for immunoinformatics benchmarking CR Weber, R Akbar, A Yermanos, M Pavlović, I Snapkov, GK Sandve, ... Bioinformatics 36 (11), 3594-3596, 2020 | 72 | 2020 |
| Deep learning enables therapeutic antibody optimization in mammalian cells by deciphering high-dimensional protein sequence space DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, S Meng, ... BioRxiv, 617860, 2019 | 58 | 2019 |
| High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity R Vazquez-Lombardi, JS Jung, FS Schlatter, A Mei, NR Mantuano, ... Immunity 55 (10), 1953-1966. e10, 2022 | 45* | 2022 |
| A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients F Bieberich, R Vazquez-Lombardi, A Yermanos, RA Ehling, DM Mason, ... Frontiers in immunology 12, 701085, 2021 | 45 | 2021 |
| Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes A Yermanos, A Agrafiotis, R Kuhn, D Robbiani, J Yates, C Papadopoulou, ... NAR genomics and bioinformatics 3 (2), lqab023, 2021 | 38 | 2021 |
| The future of blood testing is the immunome RA Arnaout, ETL Prak, N Schwab, F Rubelt, ... Frontiers in Immunology 12, 626793, 2021 | 35 | 2021 |
| AI is a viable alternative to high throughput screening: a 318-target study Scientific reports 14 (1), 7526, 2024 | 34 | 2024 |
| Individualized VDJ recombination predisposes the available Ig sequence space A Slabodkin, M Chernigovskaya, I Mikocziova, R Akbar, L Scheffer, ... Genome Research 31 (12), 2209-2224, 2021 | 34 | 2021 |
| SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display RA Ehling, CR Weber, DM Mason, S Friedensohn, B Wagner, F Bieberich, ... Cell reports 38 (3), 2022 | 24* | 2022 |
| Reference-based comparison of adaptive immune receptor repertoires CR Weber, T Rubio, L Wang, W Zhang, PA Robert, R Akbar, I Snapkov, ... Cell Reports Methods 2 (8), 2022 | 18 | 2022 |
| Systems and methods to classify antibodies D Mason, S Friedensohn, C Weber, S Reddy US Patent App. 17/439,374, 2022 | 6 | 2022 |
Sai T. ReddyAssociate Professor, ETH ZurichAdresse e-mail validée de bsse.ethz.ch