| WWP2 is an E3 ubiquitin ligase for PTEN S Maddika, S Kavela, N Rani, VR Palicharla, JL Pokorny, JN Sarkaria, ... Nature cell biology 13 (6), 728-733, 2011 | 365 | 2011 |
| Establishment, maintenance, and in vitro and in vivo applications of primary human glioblastoma multiforme (GBM) xenograft models for translational biology studies and drug … BL Carlson, JL Pokorny, MA Schroeder, JN Sarkaria Current protocols in pharmacology 52 (1), 14.16. 1-14.16. 23, 2011 | 252 | 2011 |
| Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts GJ Kitange, AC Mladek, BL Carlson, MA Schroeder, JL Pokorny, L Cen, ... Clinical Cancer Research 18 (15), 4070-4079, 2012 | 165 | 2012 |
| The role of LAT1 in 18F-DOPA uptake in malignant gliomas RS Youland, GJ Kitange, TE Peterson, DH Pafundi, JA Ramiscal, ... Journal of neuro-oncology 111, 11-18, 2013 | 158 | 2013 |
| Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma SK Gupta, SH Kizilbash, BL Carlson, AC Mladek, F Boakye-Agyeman, ... Journal of the National Cancer Institute 108 (5), djv369, 2016 | 145 | 2016 |
| Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme A Tivnan, Z Zakaria, C O'Leary, D Kögel, JL Pokorny, JN Sarkaria, ... Frontiers in neuroscience 9, 218, 2015 | 137 | 2015 |
| Active efflux of Dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly targeted agents S Agarwal, RK Mittapalli, DM Zellmer, JL Gallardo, R Donelson, C Seiler, ... Molecular cancer therapeutics 11 (10), 2183-2192, 2012 | 118 | 2012 |
| Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model KE Parrish, J Pokorny, RK Mittapalli, K Bakken, JN Sarkaria, WF Elmquist Journal of Pharmacology and Experimental Therapeutics 355 (2), 264-271, 2015 | 112 | 2015 |
| The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood–brain barrier in glioblastoma JL Pokorny, D Calligaris, SK Gupta, DO Iyekegbe Jr, D Mueller, ... Clinical cancer research 21 (8), 1916-1924, 2015 | 100 | 2015 |
| Targeting the PI3K pathway in the brain—efficacy of a PI3K inhibitor optimized to cross the blood–brain barrier L Salphati, TP Heffron, B Alicke, M Nishimura, K Barck, RA Carano, ... Clinical Cancer Research 18 (22), 6239-6248, 2012 | 82 | 2012 |
| Retinoblastoma binding protein 4 modulates temozolomide sensitivity in glioblastoma by regulating DNA repair proteins GJ Kitange, AC Mladek, MA Schroeder, JC Pokorny, BL Carlson, Y Zhang, ... Cell reports 14 (11), 2587-2598, 2016 | 78 | 2016 |
| The novel tubulin-binding ‘tumor checkpoint controller’BAL101553 has anti-cancer activity alone and in combination treatments across a panel of GBM patient-derived xenografts AC Mladek, JL Pokorny, H Lane, F Bachmann, MA Schroeder, KK Bakken, ... Cancer Research 76 (14_Supplement), 4781-4781, 2016 | 53 | 2016 |
| Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts DM Higgins, R Wang, B Milligan, M Schroeder, B Carlson, J Pokorny, ... Oncotarget 4 (5), 792, 2013 | 45 | 2013 |
| Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma CM Becker, RK Oberoi, SJ McFarren, DM Muldoon, DH Pafundi, ... Neuro-oncology 17 (9), 1210-1219, 2015 | 43 | 2015 |
| Anti-GD2-ch14. 18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and … A Tivnan, T Heilinger, JM Ramsey, G O’Connor, JL Pokorny, JN Sarkaria, ... Oncotarget 8 (10), 16605, 2017 | 40 | 2017 |
| Network modeling identifies patient-specific pathways in glioblastoma N Tuncbag, P Milani, JL Pokorny, H Johnson, TT Sio, S Dalin, ... Scientific reports 6 (1), 28668, 2016 | 37 | 2016 |
| Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models L Cen, BL Carlson, JL Pokorny, AC Mladek, PT Grogan, MA Schroeder, ... Neuro-oncology 15 (6), 735-746, 2013 | 32 | 2013 |
| BBB efflux pump activity limits brain penetration of palbociclib (PD0332991) in glioblastoma KE Parrish, JL Pokorny, RK Mittapalli, K Bakken, JN Sarkaria, ... Mol Cancer Ther 12 (11), 2013 | 11 | 2013 |
| Preclinical modeling in GBM PDX xenografts to guide clinical development of lisavanbulin—a novel tumor checkpoint controller targeting microtubules DM Burgenske, S Talele, JL Pokorny, AC Mladek, KK Bakken, BL Carlson Neuro Oncol, 2021 | 10* | 2021 |
| Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration HE Burks, JL Pokorny, JL Koetsier, QR Roth-Carter, CR Arnette, P Gerami, ... Journal of Cell Biology 222 (11), e202212031, 2023 | 9 | 2023 |
