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Gunnar Hargus, MD PhD
Gunnar Hargus, MD PhD
Assistant Professor of Pathology and Cell Biology, Columbia University
Adresse e-mail validée de cumc.columbia.edu - Page d'accueil
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Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
F Soldner, D Hockemeyer, C Beard, Q Gao, GW Bell, EG Cook, G Hargus, ...
Cell 136 (5), 964-977, 2009
20022009
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
G Hargus, O Cooper, M Deleidi, A Levy, K Lee, E Marlow, A Yow, ...
Proceedings of the National Academy of Sciences 107 (36), 15921-15926, 2010
6052010
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
P Reinhardt, B Schmid, LF Burbulla, DC Schöndorf, L Wagner, M Glatza, ...
Cell stem cell 12 (3), 354-367, 2013
5702013
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s disease
O Cooper, H Seo, S Andrabi, C Guardia-Laguarta, J Graziotto, ...
Science translational medicine 4 (141), 141ra90-141ra90, 2012
5682012
COVID-19 neuropathology at columbia university irving medical center/New York presbyterian hospital
KT Thakur, EH Miller, MD Glendinning, O Al-Dalahmah, MA Banu, ...
Brain 144 (9), 2696-2708, 2021
3752021
Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific …
O Cooper, G Hargus, M Deleidi, A Blak, T Osborn, E Marlow, K Lee, ...
Molecular and Cellular Neuroscience 45 (3), 258-266, 2010
2762010
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors
M Ehrlich, S Mozafari, M Glatza, L Starost, S Velychko, AL Hallmann, ...
Proceedings of the National Academy of Sciences 114 (11), E2243-E2252, 2017
2542017
Differentiation plasticity of chondrocytes derived from mouse embryonic stem cells
C Hegert, J Kramer, G Hargus, J Müller, K Guan, AM Wobus, PK Müller, ...
Journal of cell science 115 (23), 4617-4628, 2002
1752002
Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage
O Al-Dalahmah, KT Thakur, AS Nordvig, ML Prust, W Roth, A Lignelli, ...
Acta Neuropathologica Communications 8, 1-7, 2020
1542020
Distinct neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant TAU protein
M Ehrlich, AL Hallmann, P Reinhardt, MJ Araúzo-Bravo, S Korr, A Röpke, ...
Stem cell reports 5 (1), 83-96, 2015
1102015
Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein
AL Hallmann, MJ Araúzo-Bravo, L Mavrommatis, M Ehrlich, A Röpke, ...
Scientific reports 7 (1), 42991, 2017
1022017
Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin
I Dorn, K Klich, MJ Arauzo-Bravo, M Radstaak, S Santourlidis, F Ghanjati, ...
haematologica 100 (1), 32, 2015
972015
Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum
C Bernreuther, M Dihné, V Johann, J Schiefer, Y Cui, G Hargus, ...
Journal of Neuroscience 26 (45), 11532-11539, 2006
952006
Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery after spinal cord injury in mice
YF Cui, JC Xu, G Hargus, I Jakovcevski, M Schachner, C Bernreuther
PloS one 6 (3), e17126, 2011
762011
Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development
G Hargus, M Ehrlich, AL Hallmann, T Kuhlmann
Acta neuropathologica 127, 151-173, 2014
722014
Close homologue of adhesion molecule L1 promotes survival of Purkinje and granule cells and granule cell migration during murine cerebellar development
I Jakovcevski, J Siering, G Hargus, N Karl, L Hoelters, N Djogo, S Yin, ...
Journal of Comparative Neurology 513 (5), 496-510, 2009
712009
Development of histocompatible primate‐induced pluripotent stem cells for neural transplantation
M Deleidi, G Hargus, P Hallett, T Osborn, O Isacson
Stem cells 29 (7), 1052-1063, 2011
692011
Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice
YF Cui, G Hargus, JC Xu, JS Schmid, YQ Shen, M Glatzel, M Schachner, ...
Brain 133 (1), 189-204, 2010
672010
Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro
G Hargus, R Kist, J Kramer, D Gerstel, A Neitz, G Scherer, J Rohwedel
International Journal of Developmental Biology 52 (4), 323, 2008
572008
Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons
M Deleidi, O Cooper, G Hargus, A Levy, O Isacson
PloS one 6 (5), e19926, 2011
562011
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