| Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin CM Farinha, MD Amaral Molecular and cellular biology 25 (12), 5242-5252, 2005 | 258 | 2005 |
| Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction CM Farinha, J King-Underwood, M Sousa, AR Correia, BJ Henriques, ... Chemistry & biology 20 (7), 943-955, 2013 | 196 | 2013 |
| The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator … CM Farinha, P Nogueira, F Mendes, D Penque, MD Amaral Biochemical Journal 366 (3), 797-806, 2002 | 168 | 2002 |
| From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking CM Farinha, S Canato Cellular and molecular life sciences 74, 39-55, 2017 | 141 | 2017 |
| Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells D Penque, F Mendes, S Beck, C Farinha, P Pacheco, P Nogueira, ... Laboratory investigation 80 (6), 857-868, 2000 | 125 | 2000 |
| Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the G olgi CM Farinha, P Matos, MD Amaral The FEBS journal 280 (18), 4396-4406, 2013 | 121 | 2013 |
| Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis M D. Amaral, C M. Farinha Current pharmaceutical design 19 (19), 3497-3508, 2013 | 118 | 2013 |
| Cystic fibrosis patients with the 3272‐26A→ G mutation have mild disease, leaky alternative mRNA splicing, and CFTR protein at the cell membrane S Beck, D Penque, S Garcia, A Gomes, C Farinha, L Mata, S Gulbenkian, ... Human mutation 14 (2), 133-144, 1999 | 94 | 1999 |
| Measurements of functional responses in human primary lung cells as a basis for personalized therapy for cystic fibrosis NT Awatade, I Uliyakina, CM Farinha, LA Clarke, K Mendes, A Solé, ... EBioMedicine 2 (2), 147-153, 2015 | 92 | 2015 |
| Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation LS Pissarra, CM Farinha, Z Xu, A Schmidt, PH Thibodeau, Z Cai, ... Chemistry & biology 15 (1), 62-69, 2008 | 88 | 2008 |
| EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1 MJ Lobo, MD Amaral, M Zaccolo, CM Farinha Journal of cell science 129 (13), 2599-2612, 2016 | 80 | 2016 |
| Biochemical methods to assess CFTR expression and membrane localization CM Farinha, D Penque, M Roxo-Rosa, G Lukacs, R Dormer, ... Journal of Cystic Fibrosis 3, 73-77, 2004 | 70 | 2004 |
| Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts AS Ramalho, S Beck, CM Farinha, LA Clarke, GD Heda, B Steiner, J Sanz, ... Journal of Cystic Fibrosis 3, 11-15, 2004 | 63 | 2004 |
| Cystic fibrosis patients with the 3272-26A> G splicing mutation have milder disease than F508del homozygotes: a large European study MD Amaral, P Pacheco, S Beck, CM Farinha, D Penque, P Nogueira, ... Journal of medical genetics 38 (11), 777-783, 2001 | 63 | 2001 |
| Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity S Luz, P Kongsuphol, AI Mendes, F Romeiras, M Sousa, R Schreiber, ... Molecular and cellular biology 31 (22), 4392-4404, 2011 | 56 | 2011 |
| Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients AS Ramalho, MA Lewandowska, CM Farinha, F Mendes, J Gonçalves, ... Cellular Physiology and Biochemistry 24 (5-6), 335-346, 2009 | 56 | 2009 |
| Increased efficacy of VX‐809 in different cellular systems results from an early stabilization effect of F508del‐CFTR CM Farinha, M Sousa, S Canato, A Schmidt, I Uliyakina, MD Amaral Pharmacology Research & Perspectives 3 (4), e00152, 2015 | 55 | 2015 |
| LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells S Luz, KM Cihil, DL Brautigan, MD Amaral, CM Farinha, ... Journal of Biological Chemistry 289 (21), 15080-15093, 2014 | 54 | 2014 |
| Repairing the basic defect in cystic fibrosis–one approach is not enough CM Farinha, P Matos The FEBS journal 283 (2), 246-264, 2016 | 47 | 2016 |
| Antibodies for CFTR studies F Mendes, CM Farinha, M Roxo-Rosa, P Fanen, A Edelman, R Dormer, ... Journal of Cystic Fibrosis 3, 69-72, 2004 | 44 | 2004 |
