Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes J Yang, J Huang, M Dasgupta, N Sears, M Miyagi, B Wang, MR Chance, ... Proceedings of the National Academy of Sciences 107 (50), 21499-21504, 2010 | 367 | 2010 |
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis L Wu, X Chen, J Zhao, B Martin, JA Zepp, JS Ko, C Gu, G Cai, W Ouyang, ... Journal of Experimental Medicine 212 (10), 1571-1587, 2015 | 231 | 2015 |
The role of interleukin-17 in tumor development and progression J Zhao, X Chen, T Herjan, X Li Journal of Experimental Medicine 217 (1), e20190297, 2019 | 217 | 2019 |
Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis Y Liao, J Zhao, K Bulek, F Tang, X Chen, G Cai, S Jia, PL Fox, E Huang, ... Nature communications 11 (1), 900, 2020 | 169 | 2020 |
Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis K Bulek, J Zhao, Y Liao, N Rana, D Corridoni, A Antanaviciute, X Chen, ... The Journal of clinical investigation 130 (8), 4218-4234, 2020 | 165 | 2020 |
IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling T Herjan, L Hong, J Bubenik, K Bulek, W Qian, C Liu, X Li, X Chen, ... Nature immunology 19 (4), 354-365, 2018 | 118 | 2018 |
TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non–small cell lung cancers J Nan, Y Du, X Chen, Q Bai, Y Wang, X Zhang, N Zhu, J Zhang, J Hou, ... Molecular cancer therapeutics 13 (3), 617-629, 2014 | 108 | 2014 |
IL-17R–EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells X Chen, G Cai, C Liu, J Zhao, C Gu, L Wu, TA Hamilton, C Zhang, J Ko, ... Journal of Experimental Medicine 216 (1), 195-214, 2019 | 106 | 2019 |
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, ... The Journal of clinical investigation 128 (12), 5399-5412, 2018 | 106 | 2018 |
The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo C Liu, L Zhu, K Fukuda, S Ouyang, X Chen, C Wang, C Zhang, B Martin, ... Science signaling 10 (467), eaaf8823, 2017 | 79 | 2017 |
Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells X Chen, Y Du, J Nan, X Zhang, X Qin, Y Wang, J Hou, Q Wang, J Yang PLoS One 8 (5), e63697, 2013 | 76 | 2013 |
IL-17A–induced PLET1 expression contributes to tissue repair and colon tumorigenesis JA Zepp, J Zhao, C Liu, K Bulek, L Wu, X Chen, Y Hao, Z Wang, X Wang, ... The Journal of Immunology 199 (11), 3849-3857, 2017 | 69 | 2017 |
Targeting IL-17A/glucocorticoid synergy to CSF3 expression in neutrophilic airway diseases S Ouyang, C Liu, J Xiao, X Chen, AC Lui, X Li JCI insight 5 (3), e132836, 2020 | 53 | 2020 |
STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway J He, J Shi, X Xu, W Zhang, Y Wang, X Chen, Y Du, N Zhu, J Zhang, ... Journal of biosciences 37, 243-257, 2012 | 44 | 2012 |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 CJ Zhang, C Wang, M Jiang, C Gu, J Xiao, X Chen, BN Martin, F Tang, ... Nature communications 9 (1), 2745, 2018 | 43 | 2018 |
IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs H Zhou, K Bulek, X Li, T Herjan, M Yu, W Qian, H Wang, G Zhou, X Chen, ... Elife 6, e29630, 2017 | 39 | 2017 |
IL-17–induced HIF1α drives resistance to anti–PD-L1 via fibroblast-mediated immune exclusion X Chen, J Zhao, T Herjan, L Hong, Y Liao, C Liu, K Vasu, H Wang, ... Journal of Experimental Medicine 219 (6), 2022 | 33 | 2022 |
Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice H Wang, H Zhou, Q Zhang, KL Poulsen, V Taylor, MR McMullen, ... Journal of hepatology 73 (6), 1470-1481, 2020 | 30 | 2020 |
Regulation of expression of trehalose-6-phosphate synthase during cold shock in Arthrobacter strain A3 XM Chen, Y Jiang, YT Li, HH Zhang, J Li, X Chen, Q Zhao, J Zhao, J Si, ... Extremophiles 15, 499-508, 2011 | 26 | 2011 |
Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer N Zhu, J Zhang, Y Du, X Qin, R Miao, J Nan, X Chen, J Sun, R Zhao, ... Proceedings of the National Academy of Sciences 117 (26), 15047-15054, 2020 | 25 | 2020 |