Brendan D. Manning

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Lewis CantleyDana Farber Cancer Center and Harvard Medical SchoolAdresse e-mail validée de med.cornell.edu
John AsaraAssociate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical CenterAdresse e-mail validée de bidmc.harvard.edu
Issam Ben-SahraNorthwestern UniversityAdresse e-mail validée de northwestern.edu
David J. KwiatkowskiProfessor of Medicine, Harvard Medical SchoolAdresse e-mail validée de rics.bwh.harvard.edu
Gerta HoxhajUT Southwestern Medical CenterAdresse e-mail validée de utsouthwestern.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineAdresse e-mail validée de med.cornell.edu
Andrew TeeProfessor of Cancer and GeneticsAdresse e-mail validée de cardiff.ac.uk
Reuben ShawThe Salk Institute of Biological StudiesAdresse e-mail validée de salk.edu
Mustafa SahinBoston Children's Hospital; Harvard Medical SchoolAdresse e-mail validée de childrens.harvard.edu
Clary ClishSenior Director, Metabolomics, Broad Institute of MIT and HarvardAdresse e-mail validée de broadinstitute.org
James MitchellAssociate Professor of Genetics and Complex Diseases, Harvard T. H. Chan School of Public HealthAdresse e-mail validée de hsph.harvard.edu
Michael MacArthurPrinceton UniversityAdresse e-mail validée de princeton.edu
Michael SnyderStanford UniversityAdresse e-mail validée de stanford.edu
Alex TokerAdresse e-mail validée de bidmc.harvard.edu
George TalbottVerndari IncAdresse e-mail validée de verndariinc.com
Elizabeth P HenskeProfessor of Medicine, Harvard Medical SchoolAdresse e-mail validée de bwh.harvard.edu
Benjamin HousdenLiving Systems Institute, University of ExeterAdresse e-mail validée de exeter.ac.uk
Chin-Lee WuMassachusetts General HospitalAdresse e-mail validée de mgh.harvard.edu
Pichai RamanBioinformatics Leader at Spark TherapeuticsAdresse e-mail validée de sparktx.com
Anthony J. Covarrubias, PhDAssistant Professor. UCLA David Geffen School of Medicine and Division of Life SciencesAdresse e-mail validée de mednet.ucla.edu

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Brendan D. Manning

Harvard University

Adresse e-mail validée de hsph.harvard.edu - Page d'accueil

Signaling Metabolism Tumors


Titre Trier par citations Trier par année Trier par titre	Citée par Citée par	Année
AKT/PKB signaling: navigating downstream BD Manning, LC Cantley Cell 129 (7), 1261-1274, 2007	7564	2007
AKT/PKB signaling: navigating the network BD Manning, A Toker Cell 169 (3), 381-405, 2017	3555	2017
Activation of a metabolic gene regulatory network downstream of mTOR complex 1 K Düvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, ... Molecular cell 39 (2), 171-183, 2010	2357	2010
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway BD Manning, AR Tee, MN Logsdon, J Blenis, LC Cantley Molecular cell 10 (1), 151-162, 2002	1969	2002
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex J Brugarolas, K Lei, RL Hurley, BD Manning, JH Reiling, E Hafen, ... Genes & development 18 (23), 2893-2904, 2004	1728	2004
Targeting the PI3K-Akt pathway in human cancer: rationale and promise J Luo, BD Manning, LC Cantley Cancer cell 4 (4), 257-262, 2003	1714	2003
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism G Hoxhaj, BD Manning Nature Reviews Cancer 20 (2), 74-88, 2020	1628	2020
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb AR Tee, BD Manning, PP Roux, LC Cantley, J Blenis Current biology 13 (15), 1259-1268, 2003	1548	2003
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth J Huang, BD Manning Biochemical Journal 412 (2), 179-190, 2008	1519	2008
The LKB1 tumor suppressor negatively regulates mTOR signaling RJ Shaw, N Bardeesy, BD Manning, L Lopez, M Kosmatka, RA DePinho, ... Cancer cell 6 (1), 91-99, 2004	1291	2004
Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling AR Tee, DC Fingar, BD Manning, DJ Kwiatkowski, LC Cantley, J Blenis Proceedings of the National Academy of Sciences 99 (21), 13571-13576, 2002	1046	2002
A complex interplay between Akt, TSC2 and the two mTOR complexes J Huang, BD Manning Biochemical Society Transactions 37 (1), 217-222, 2009	921	2009
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome S Menon, CC Dibble, G Talbott, G Hoxhaj, AJ Valvezan, H Takahashi, ... Cell 156 (4), 771-785, 2014	889	2014
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1 I Ben-Sahra, JJ Howell, JM Asara, BD Manning Science 339 (6125), 1323-1328, 2013	846	2013
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning Science 351 (6274), 728-733, 2016	822	2016
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output CC Dibble, BD Manning Nature cell biology 15 (6), 555-564, 2013	819	2013
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ... Nature cell biology 16 (11), 1069-1079, 2014	718	2014
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways JL Yecies, HH Zhang, S Menon, S Liu, D Yecies, AI Lipovsky, C Gorgun, ... Cell metabolism 14 (1), 21-32, 2011	708	2011
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 CC Dibble, W Elis, S Menon, W Qin, J Klekota, JM Asara, PM Finan, ... Molecular cell 47 (4), 535-546, 2012	706	2012
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2 J Huang, CC Dibble, M Matsuzaki, BD Manning Molecular and cellular biology 28 (12), 4104-4115, 2008	672	2008

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