Suivre
Yash Agarwal
Yash Agarwal
Associate Director, TwoStep Therapeutics
Adresse e-mail validée de alum.mit.edu
Titre
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Année
Engineered immunogen binding to alum adjuvant enhances humoral immunity
TJ Moyer, Y Kato, W Abraham, JYH Chang, DW Kulp, N Watson, ...
Nature Medicine 26 (3), 430-440, 2020
2352020
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity
Y Agarwal, LE Milling, JYH Chang, L Santollani, A Sheen, EA Lutz, ...
Nature biomedical engineering 6 (2), 129-143, 2022
1062022
High-performance chemical-and light-inducible recombinases in mammalian cells and mice
BH Weinberg, JH Cho, Y Agarwal, NTH Pham, LD Caraballo, M Walkosz, ...
Nature communications 10 (1), 4845, 2019
672019
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
KS Gordon, T Kyung, CR Perez, PV Holec, A Ramos, AQ Zhang, ...
Nature biomedical engineering 6 (7), 855-866, 2022
422022
Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade
C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, ...
Cell reports 37 (8), 2021
312021
Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies
EA Lutz, Y Agarwal, N Momin, SC Cowles, JR Palmeri, E Duong, V Hornet, ...
Proceedings of the National Academy of Sciences 119 (36), e2205983119, 2022
262022
Neoadjuvant STING activation, extended half-life IL2, and checkpoint blockade promote metastasis clearance via sustained NK-cell activation
LE Milling, D Garafola, Y Agarwal, S Wu, A Thomas, N Donahue, J Adams, ...
Cancer immunology research 10 (1), 26-39, 2022
162022
Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models
A Sheen, Y Agarwal, KM Cheah, SC Cowles, JA Stinson, JR Palmeri, ...
Redox Biology 64, 102766, 2023
102023
Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2
BL Horton, A D D’Souza, M Zagorulya, CV McCreery, GC Abhiraman, ...
JCI insight 8 (19), e172728, 2023
92023
Co‐anchoring of engineered immunogen and immunostimulatory cytokines to alum promotes enhanced‐humoral immunity
JYH Chang, Y Agarwal, KA Rodrigues, N Momin, K Ni, BJ Read, TJ Moyer, ...
Advanced Therapeutics 5 (7), 2100235, 2022
72022
Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity
TJ Moyer, Y Kato, W Abraham, JYH Chang, DW Kulp, N Watson, ...
Nature Medicine 26 (5), 804-804, 2020
72020
Optimization of an alum-anchored clinical HIV vaccine candidate
KA Rodrigues, CA Cottrell, JM Steichen, B Groschel, W Abraham, H Suh, ...
npj Vaccines 8 (1), 117, 2023
62023
1087 Addition of IL-2 overcomes lung tumor resistance to IL-12 by coordinating cytotoxic and regulatory T cell responses
B Horton, M Zagorulya, N Momin, Y Agarwal, K Wittrup, S Spranger
J Immunother Cancer 10 (Suppl 2), A1-A1603, 2022
32022
Reprogramming brain immunosurveillance with engineered cytokines
A Tabet, Y Agarwal, J Stinson, C Apra, V Will, M Manthey, N Momin, ...
bioRxiv, 2022.06. 21.497082, 2022
12022
A materials-based approach for localized delivery of cancer immunotherapy
Y Agarwal
Massachusetts Institute of Technology, 2022
2022
738 Intratumoral administration of alum-tethered engineered inflammatory cytokines safely elicits potent local and systemic immunity
Y Agarwal, K Wittrup, D Irvine
Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021
2021
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