| Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir HS Lo, KPY Hui, HM Lai, X He, KS Khan, S Kaur, J Huang, Z Li, ... ACS Central Science 7 (5), 792-802, 2021 | 86 | 2021 |
| Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions AKN Chan, CW Chen Frontiers in Cell and Developmental Biology 7, 81, 2019 | 86 | 2019 |
| High-resolution characterization of gene function using single-cell CRISPR tiling screen L Yang, AKN Chan, K Miyashita, CD Delaney, X Wang, H Li, SP Pokharel, ... Nature Communications 12 (4063), 1-9, 2021 | 39 | 2021 |
| Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells RS Sellar, AS Sperling, M Słabicki, JA Gasser, ME McConkey, ... The Journal of clinical investigation 132 (16), 2022 | 35 | 2022 |
| 3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia Q Liu, AKN Chan, WH Chang, L Yang, SP Pokharel, K Miyashita, ... Leukemia 36 (1), 100-110, 2022 | 30 | 2022 |
| Engineering of efficient Escherichia coli excretion systems for the production of heterologous proteins for commercial applications WKR Wong, Z Fu, YY Wang, KL Ng, AKN Chan Recent Patents on Chemical Engineering 5 (1), 44-55, 2012 | 24 | 2012 |
| Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1‐EEF1A1 Axis M Li, L Yang, AKN Chan, SP Pokharel, Q Liu, N Mattson, X Xu, WH Chang, ... Advanced Science 10 (17), 2206584, 2023 | 22 | 2023 |
| Enhancement of excretory production of an exoglucanase from Escherichia coli with phage shock protein A (PspA) overexpression YY Wang, ZB Fu, KL Ng, CC Lam, AKN Chan, KF Sze, WKR Wong Journal of Microbiology and Biotechnology 21 (6), 637-645, 2011 | 22 | 2011 |
| Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain M Brand, J Clayton, M Moroglu, M Schiedel, S Picaud, J Bluck, ... Journal of Medicinal Chemistry 64 (14), 10102-10123, 2021 | 21 | 2021 |
| Concise and stereodivergent synthesis of carbasugars reveals unexpected structure-activity relationship (SAR) of SGLT2 inhibition WL Ng, HC Li, KM Lau, AKN Chan, C Bik-San Lau, TKM Shing Scientific Reports 7 (1), 5581, 2017 | 20 | 2017 |
| METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation M Xue, L Dong, H Zhang, Y Li, K Qiu, Z Zhao, M Gao, L Han, AKN Chan, ... Journal of Hematology & Oncology 17 (1), 7, 2024 | 18 | 2024 |
| Cloning and characterization of a novel cellobiase gene, cba3, encoding the first known β-glucosidase of glycoside hydrolase family 1 of Cellulomonas biazotea AKN Chan, YY Wang, KL Ng, Z Fu, WKR Wong Gene 493 (1), 52-61, 2012 | 15 | 2012 |
| Fragment-based identification of ligands for bromodomain-containing factor 3 of Trypanosoma cruzi CMC Laurin, JP Bluck, AKN Chan, M Keller, A Boczek, AR Scorah, ... ACS Infectious Diseases 7 (8), 2238−2249, 2021 | 13 | 2021 |
| Adenosine monophosphate binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system C Pliotas, SC Grayer, S Ekkerman, AKN Chan, J Healy, P Marius, ... Biochemistry 56 (32), 4219-4234, 2017 | 13 | 2017 |
| Efficient Bacillus subtilis promoters for graded expression of heterologous genes in Escherichia coli YY Wang, KL Ng, CC Lam, KN Chan, KF Sze, ZB Fu, WKR Wong Research Journal of Biotechnology 5 (4), 5-14, 2010 | 13 | 2010 |
| Cloning and characterization of two novel β-glucosidase genes encoding isoenzymes of the cellobiase complex from Cellulomonas biazotea AKN Chan, AKL Ng, KKY Ng, WKR Wong Gene 642, 367–375, 2018 | 11 | 2018 |
| Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia A Kumar, AT Khani, C Duault, S Aramburo, AS Ortiz, SJ Lee, A Chan, ... Journal for Immunotherapy of Cancer 11 (5), e006649, 2023 | 10 | 2023 |
| ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner X Xu, AKN Chan, M Li, Q Liu, N Mattson, S Pangeni Pokharel, WH Chang, ... Science Advances 8 (51), eadc8911, 2022 | 8 | 2022 |
| A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens NM Mattson, AKN Chan, K Miyashita, E Mukhaleva, WH Chang, L Yang, ... Nature Structural & Molecular Biology 31 (3), 465-475, 2024 | 7 | 2024 |
| Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications A Kumar, SJ Lee, Q Liu, AKN Chan, SP Pokharel, J Yu, CW Chen, ... STAR Protocols 2 (4), 100874, 2021 | 7 | 2021 |
Chun-Wei Chen (David Chen)Beckman Research Institute / City of HopeAdresse e-mail validée de coh.org
