Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease P Agostinho, R A Cunha, C Oliveira Current pharmaceutical design 16 (25), 2766-2778, 2010 | 780 | 2010 |
Adenosine receptors and brain diseases: neuroprotection and neurodegeneration CV Gomes, MP Kaster, AR Tomé, PM Agostinho, RA Cunha Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (5), 1380-1399, 2011 | 520 | 2011 |
Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress MP Kaster, NJ Machado, HB Silva, A Nunes, AP Ardais, M Santana, ... Proceedings of the National Academy of Sciences 112 (25), 7833-7838, 2015 | 338 | 2015 |
Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide JB Melo, P Agostinho, CR Oliveira Neuroscience Research 45 (1), 117-127, 2003 | 318 | 2003 |
Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades M Matos, E Augusto, CR Oliveira, P Agostinho Neuroscience 156 (4), 898-910, 2008 | 311 | 2008 |
Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline RA Cunha, PM Agostinho Journal of Alzheimer's Disease 20 (s1), S95-S116, 2010 | 293 | 2010 |
Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction N Rebola, AP Simões, PM Canas, AR Tomé, GM Andrade, CE Barry, ... Journal of neurochemistry 117 (1), 100-111, 2011 | 231 | 2011 |
Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing AR Costenla, MJ Diógenes, PM Canas, RJ Rodrigues, C Nogueira, ... European Journal of Neuroscience 34 (1), 12-21, 2011 | 200 | 2011 |
Depression as a glial-based synaptic dysfunction D Rial, C Lemos, H Pinheiro, JM Duarte, FQ Gonçalves, JI Real, ... Frontiers in cellular neuroscience 9, 521, 2016 | 194 | 2016 |
Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies C Pereira, P Agostinho, PI Moreira, SM Cardoso, CR Oliveira Current Drug Targets-CNS & Neurological Disorders 4 (4), 383-403, 2005 | 186 | 2005 |
Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes M Matos, E Augusto, AD Santos‐Rodrigues, MA Schwarzschild, JF Chen, ... Glia 60 (5), 702-716, 2012 | 171 | 2012 |
Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice JMN Duarte, PM Agostinho, RA Carvalho, RA Cunha PLoS one 7 (4), e21899, 2012 | 162 | 2012 |
Astrocytic adenosine A 2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake M Matos, E Augusto, NJ Machado, A dos Santos-Rodrigues, RA Cunha, ... Journal of Alzheimer's Disease 31 (3), 555-567, 2012 | 157 | 2012 |
Cdk5: multitasking between physiological and pathological conditions JP Lopes, P Agostinho Progress in neurobiology 94 (1), 49-63, 2011 | 157 | 2011 |
Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia M Matos, HY Shen, E Augusto, Y Wang, CJ Wei, YT Wang, P Agostinho, ... Biological psychiatry 78 (11), 763-774, 2015 | 150 | 2015 |
Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life GP Cognato, PM Agostinho, J Hockemeyer, CE Müller, DO Souza, ... Journal of neurochemistry 112 (2), 453-462, 2010 | 149 | 2010 |
Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes M Matos, E Augusto, P Agostinho, RA Cunha, JF Chen Journal of Neuroscience 33 (47), 18492-18502, 2013 | 139 | 2013 |
Susceptibility of hippocampal neurons to Aβ peptide toxicity is associated with perturbation of Ca2+ homeostasis R Resende, C Pereira, P Agostinho, AP Vieira, JO Malva, CR Oliveira Brain research 1143, 11-21, 2007 | 135 | 2007 |
Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type JM Gutierres, FB Carvalho, MRC Schetinger, P Marisco, P Agostinho, ... Life sciences 96 (1-2), 7-17, 2014 | 134 | 2014 |
Spatial memory impairments in a prediabetic rat model E Soares, RD Prediger, S Nunes, AA Castro, SD Viana, C Lemos, ... Neuroscience 250, 565-577, 2013 | 125 | 2013 |