Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms JM Flynn, N Samant, G Schneider-Nachum, DT Barkan, NK Yilmaz, ... Elife 11, e77433, 2022 | 90 | 2022 |
Picomolar to micromolar: elucidating the role of distal mutations in HIV-1 protease in conferring drug resistance M Henes, GJ Lockbaum, K Kosovrasti, F Leidner, GS Nachum, ... ACS chemical biology 14 (11), 2441-2452, 2019 | 50 | 2019 |
Structural adaptation of darunavir analogues against primary mutations in HIV-1 protease GJ Lockbaum, F Leidner, LN Rusere, M Henes, K Kosovrasti, GS Nachum, ... ACS infectious diseases 5 (2), 316-325, 2018 | 37 | 2018 |
Molecular determinants of epistasis in HIV-1 protease: Elucidating the interdependence of L89V and L90M mutations in resistance M Henes, K Kosovrasti, GJ Lockbaum, F Leidner, GS Nachum, ... Biochemistry 58 (35), 3711-3726, 2019 | 22 | 2019 |
Constrained mutational sampling of amino acids in HIV-1 protease evolution JI Boucher, TW Whitfield, A Dauphin, G Nachum, C Hollins III, ... Molecular biology and evolution 36 (4), 798-810, 2019 | 15 | 2019 |
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness G Schneider-Nachum, J Flynn, D Mavor, CA Schiffer, DNA Bolon Virus Evolution 7 (2), veab103, 2021 | 3 | 2021 |
Mutational fitness landscape and drug resistance J Flynn, N Samant, G Schneider-Nachum, T Tenzin, DNA Bolon Current opinion in structural biology 78, 102525, 2023 | 2 | 2023 |
Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease GJ Lockbaum, F Leidner, LN Rusere, M Henes, K Kosovrasti, GS Nachum, ... ACS infectious diseases 5 (6), 1044-1044, 2019 | 2 | 2019 |
Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by HIV protease N Samant, G Nachum, T Tsepal, DNA Bolon Protein Science 31 (7), e4366, 2022 | 1 | 2022 |
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness GS Nachum, JM Flynn, D Mavor, CA Schiffer, DNA Bolon | | 2021 |