Suivre
Hélène Gleitz
Hélène Gleitz
Assistant Professor, Erasmus MC
Adresse e-mail validée de erasmusmc.nl
Titre
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Année
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
NB Leimkühler, HFE Gleitz, L Ronghui, IAM Snoeren, SNR Fuchs, ...
Cell stem cell 28 (4), 637-652. e8, 2021
1262021
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
J Tordo, C O’Leary, ASLM Antunes, N Palomar, P Aldrin-Kirk, M Basche, ...
Brain 141 (7), 2014-2031, 2018
1102018
Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms
HFE Gleitz, AY Liao, JR Cook, SF Rowlston, GMA Forte, Z D'souza, ...
EMBO molecular medicine 10 (7), e8730, 2018
902018
Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy
RJ Holley, SM Ellison, D Fil, C O’Leary, J McDermott, N Senthivel, ...
Brain 141 (1), 99-116, 2018
832018
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN
HFE Gleitz, AJF Dugourd, NB Leimkühler, IAM Snoeren, SNR Fuchs, ...
Blood, The Journal of the American Society of Hematology 136 (18), 2051-2064, 2020
822020
Still a burning question: the interplay between inflammation and fibrosis in myeloproliferative neoplasms
HFE Gleitz, A Benabid, RK Schneider
Current Opinion in Hematology 28 (5), 364-371, 2021
522021
Biological drivers of clinical phenotype in myelofibrosis
J Mascarenhas, HFE Gleitz, HT Chifotides, CN Harrison, S Verstovsek, ...
Leukemia 37 (2), 255-264, 2023
392023
Identification of age-dependent motor and neuropsychological behavioural abnormalities in a mouse model of Mucopolysaccharidosis Type II
HFE Gleitz, C O’Leary, RJ Holley, BW Bigger
PLoS One 12 (2), e0172435, 2017
282017
Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis
HFE Gleitz, R Kramann, RK Schneider
The Journal of pathology 245 (2), 138-146, 2018
262018
An improved adeno-associated virus vector for neurological correction of the mouse model of mucopolysaccharidosis IIIA
AL Gray, C O'Leary, A Liao, L Agúndez, AS Youshani, HF Gleitz, H Parker, ...
Human Gene Therapy 30 (9), 1052-1066, 2019
192019
Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion
USA Stalmann, F Ticconi, IAM Snoeren, R Li, HFE Gleitz, GS Cowley, ...
Blood Advances 6 (6), 1780-1796, 2022
82022
Isolation of human bone marrow stromal cells from bone marrow biopsies for single-cell RNA sequencing
HFE Gleitz, IAM Snoeren, SNR Fuchs, NB Leimkühler, RK Schneider
STAR protocols 2 (2), 100538, 2021
72021
Sustained long-term disease correction in a murine model of MPSII following stem cell gene therapy
S Ellison, A Liao, HFE Gleitz, H Parker, L Booth, J Robinson, S Wood, ...
Molecular Therapy-Methods & Clinical Development 31, 2023
42023
S205: Inhibiting the alarmin-driven hematopoiesis-stromal cells crosstalk in primary myelofibrosis ameliorates bone marrow fibrosis
H Gleitz, I Snoeren, S Fuchs, J Nagai, A Dugourd, C Boys, V Klöker, ...
HemaSphere 7 (Suppl), e36177f7, 2023
22023
Fibrosis driving myofibroblast precursors in MPN and new therapeutic pathways
HFE Gleitz, JE Pritchard, R Kramann, RK Schneider
HemaSphere 3, 142-145, 2019
22019
Fusion of Rabies Virus Glycoprotein or gh625 to Iduronate-2-Sulfatase for the Treatment of Mucopolysaccharidosis Type II
SR Wood, A Chaudrhy, S Ellison, R Searle, C Burgod, G Tehseen, ...
Human Gene Therapy 35 (7-8), 232-242, 2024
12024
Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation
SNR Fuchs, USA Stalmann, IAM Snoeren, E Bindels, S Schmitz, ...
Blood Advances 8 (3), 766-779, 2024
12024
“ASXL1”-erating inflammation and bone marrow fibrosis in myeloproliferative neoplasms
HFE Gleitz, RK Schneider
Haematologica 108 (5), 1203, 2022
12022
Transcriptional Landscape of the Microenvironment in Bone Marrow Fibrosis at Single Cell Level
NB Leimkühler, R Li, H Gleitz, I Snoeren, S Fuchs, M Crysandt, ...
Blood 134, 1675, 2019
12019
Brain targeted stem cell gene therapy provides long-term correction of mucopolysaccharidosis type II
B Bigger, AY Liao, H Gleitz, R Holley
Molecular Genetics and Metabolism 126 (2), S31-S32, 2019
12019
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