| NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals P Duewell, H Kono, KJ Rayner, CM Sirois, G Vladimer, FG Bauernfeind, ... Nature 464 (7293), 1357-1361, 2010 | 4246 | 2010 |
| Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization V Hornung, F Bauernfeind, A Halle, EO Samstad, H Kono, KL Rock, ... Nature immunology 9 (8), 847-856, 2008 | 3504 | 2008 |
| IKKε and TBK1 are essential components of the IRF3 signaling pathway KA Fitzgerald, SM McWhirter, KL Faia, DC Rowe, E Latz, DT Golenbock, ... Nature immunology 4 (5), 491-496, 2003 | 3332 | 2003 |
| Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression FG Bauernfeind, G Horvath, A Stutz, ES Alnemri, K MacDonald, D Speert, ... The Journal of Immunology 183 (2), 787-791, 2009 | 3204 | 2009 |
| Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome K Nakahira, JA Haspel, VAK Rathinam, SJ Lee, T Dolinay, HC Lam, ... Nature immunology 12 (3), 222-230, 2011 | 3109 | 2011 |
| AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC V Hornung, A Ablasser, M Charrel-Dennis, F Bauernfeind, G Horvath, ... Nature 458 (7237), 514-518, 2009 | 2964 | 2009 |
| The NALP3 inflammasome is involved in the innate immune response to amyloid-β A Halle, V Hornung, GC Petzold, CR Stewart, BG Monks, T Reinheckel, ... Nature immunology 9 (8), 857-865, 2008 | 2853 | 2008 |
| Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis K Shimada, TR Crother, J Karlin, J Dagvadorj, N Chiba, S Chen, ... Immunity 36 (3), 401-414, 2012 | 2171 | 2012 |
| IFI16 is an innate immune sensor for intracellular DNA L Unterholzner, SE Keating, M Baran, KA Horan, SB Jensen, S Sharma, ... Nature immunology 11 (11), 997-1004, 2010 | 1922 | 2010 |
| Toll-like receptors and the control of immunity KA Fitzgerald, JC Kagan Cell 180 (6), 1044-1066, 2020 | 1773 | 2020 |
| STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors SR Woo, MB Fuertes, L Corrales, S Spranger, MJ Furdyna, MYK Leung, ... Immunity 41 (5), 830-842, 2014 | 1772 | 2014 |
| TLR9 signals after translocating from the ER to CpG DNA in the lysosome E Latz, A Schoenemeyer, A Visintin, KA Fitzgerald, BG Monks, CF Knetter, ... Nature immunology 5 (2), 190-198, 2004 | 1770 | 2004 |
| Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction KA Fitzgerald, EM Palsson-McDermott, AG Bowie, CA Jefferies, ... Nature 413 (6851), 78-83, 2001 | 1720 | 2001 |
| Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE J Tian, AM Avalos, SY Mao, B Chen, K Senthil, H Wu, P Parroche, ... Nature immunology 8 (5), 487-496, 2007 | 1699 | 2007 |
| LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF KA Fitzgerald, DC Rowe, BJ Barnes, DR Caffrey, A Visintin, E Latz, ... The Journal of experimental medicine 198 (7), 1043-1055, 2003 | 1650 | 2003 |
| The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses VAK Rathinam, Z Jiang, SN Waggoner, S Sharma, LE Cole, L Waggoner, ... Nature immunology 11 (5), 395-402, 2010 | 1546 | 2010 |
| Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction CS Shi, K Shenderov, NN Huang, J Kabat, M Abu-Asab, KA Fitzgerald, ... Nature immunology 13 (3), 255-263, 2012 | 1486 | 2012 |
| Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand, MR Vos, GF Schröder, ... Cell 156 (6), 1193-1206, 2014 | 1357 | 2014 |
| DNA sensing by the cGAS–STING pathway in health and disease M Motwani, S Pesiridis, KA Fitzgerald Nature Reviews Genetics 20 (11), 657-674, 2019 | 1188 | 2019 |
| RIG-I-dependent sensing of poly (dA: dT) through the induction of an RNA polymerase III–transcribed RNA intermediate A Ablasser, F Bauernfeind, G Hartmann, E Latz, KA Fitzgerald, V Hornung Nature immunology 10 (10), 1065-1072, 2009 | 1120 | 2009 |
Daniel CaffreyUniversity of Massachusetts Medical SchoolAdresse e-mail validée de umassmed.edu
