| Mechanisms for T cell receptor triggering PA Van Der Merwe, O Dushek Nature Reviews Immunology 11 (1), 47-55, 2011 | 645 | 2011 |
| Constitutively active Lck kinase in T cells drives antigen receptor signal transduction K Nika, C Soldani, M Salek, W Paster, A Gray, R Etzensperger, L Fugger, ... Immunity 32 (6), 766-777, 2010 | 425 | 2010 |
| The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor B Treanor, D Depoil, A Gonzalez-Granja, P Barral, M Weber, O Dushek, ... Immunity 32 (2), 187-199, 2010 | 382 | 2010 |
| Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics MI Barton, SA MacGowan, MA Kutuzov, O Dushek, GJ Barton, ... Elife 10, e70658, 2021 | 341 | 2021 |
| Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ... Immunity 32 (2), 163-174, 2010 | 299 | 2010 |
| PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy A Azad, S Yin Lim, Z D'Costa, K Jones, A Diana, OJ Sansom, P Kruger, ... EMBO molecular medicine 9 (2), 167-180, 2017 | 212 | 2017 |
| Phenotypic models of T cell activation M Lever, PK Maini, PA Van Der Merwe, O Dushek Nature Reviews Immunology 14 (9), 619-629, 2014 | 207 | 2014 |
| Comparison of T cell activities mediated by human TCRs and CARs that use the same recognition domains DT Harris, MV Hager, SN Smith, Q Cai, JD Stone, P Kruger, M Lever, ... The Journal of Immunology 200 (3), 1088-1100, 2018 | 186 | 2018 |
| Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling H Zhang, SP Cordoba, O Dushek, P Anton Van Der Merwe Proceedings of the National Academy of Sciences 108 (48), 19323-19328, 2011 | 149 | 2011 |
| A THEMIS: SHP 1 complex promotes T‐cell survival W Paster, AM Bruger, K Katsch, C Grégoire, R Roncagalli, G Fu, ... The EMBO journal 34 (3), 393-409, 2015 | 118 | 2015 |
| Non‐catalytic tyrosine‐phosphorylated receptors O Dushek, J Goyette, PA van der Merwe Immunological reviews 250 (1), 258-276, 2012 | 104 | 2012 |
| The discriminatory power of the T cell receptor J Pettmann, A Huhn, E Abu Shah, MA Kutuzov, DB Wilson, ML Dustin, ... Elife 10, e67092, 2021 | 99* | 2021 |
| A role for rebinding in rapid and reliable T cell responses to antigen O Dushek, R Das, D Coombs PLoS computational biology 5 (11), e1000578, 2009 | 99 | 2009 |
| Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ... Science signaling 4 (176), ra39-ra39, 2011 | 96 | 2011 |
| Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose M Lever, HS Lim, P Kruger, J Nguyen, N Trendel, E Abu-Shah, PK Maini, ... Proceedings of the National Academy of Sciences 113 (43), E6630-E6638, 2016 | 95 | 2016 |
| Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function B Salzer, CM Schueller, CU Zajc, T Peters, MA Schoeber, B Kovacic, ... Nature Communications 11 (1), 4166, 2020 | 87 | 2020 |
| A cell topography-based mechanism for ligand discrimination by the T cell receptor RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, ... Proceedings of the National Academy of Sciences 116 (28), 14002-14010, 2019 | 87 | 2019 |
| An induced rebinding model of antigen discrimination O Dushek, PA Van der Merwe Trends in immunology 35 (4), 153-158, 2014 | 86 | 2014 |
| TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding L Limozin, M Bridge, P Bongrand, O Dushek, PA van Der Merwe, ... Proceedings of the National Academy of Sciences 116 (34), 16943-16948, 2019 | 85 | 2019 |
| SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly M Fairhead, G Veggiani, M Lever, J Yan, D Mesner, CV Robinson, ... Journal of the American Chemical Society 136 (35), 12355-12363, 2014 | 81 | 2014 |
Philip Anton van der MerweProfessor of Molecular Immunology, University of OxfordAdresse e-mail validée de path.ox.ac.uk
