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Gustavo Machado Alvares de Lima
Gustavo Machado Alvares de Lima
Astex Pharmaceuticals
Adresse e-mail validée de astx.com - Page d'accueil
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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
AS Godoy, GMA Lima, KIZ Oliveira, NU Torres, FV Maluf, RVC Guido, ...
Nature communications 8 (1), 1-6, 2017
1272017
BioMAX – the first macromolecular crystallography beamline at MAX IV Laboratory
T Ursby, K Åhnberg, R Appio, O Aurelius, A Barczyk, A Bartalesi, M Bjelčić, ...
Journal of Synchrotron Radiation, 2020
762020
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
ASG G. D. Noske, A. M. Nakamura, V. O. Gawriljuk, R. S. Fernandes, G. M. A ...
Journal of Molecular Biology, 2021
662021
Friedelin synthase from Maytenus ilicifolia: leucine 482 plays an essential role in the production of the most rearranged pentacyclic triterpene
TM Souza-Moreira, TB Alves, KA Pinheiro, LG Felippe, GMA De Lima, ...
Scientific reports 6 (1), 1-13, 2016
452016
F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening
Jan Wollenhaupt, Alexander Metz, Tatjana Barthel, Gustavo M.A. Lima, Andreas ...
Structure, 2020
442020
FragMAX: the fragment-screening platform at the MAX IV Laboratory
GMA Lima, VO Talibov, E Jagudin, C Sele, M Nyblom, W Knecht, ...
Acta Crystallographica Section D: Structural Biology 76 (8), 771-777, 2020
422020
In vivo and in vitro auranofin activity against Trypanosoma cruzi: Possible new uses for an old drug
MTA da Silva, I Silva-Jardim, GB Portapilla, GMA de Lima, FC Costa, ...
Experimental parasitology 166, 189-193, 2016
392016
Ceratocystis cacaofunesta genome analysis reveals a large expansion of extracellular phosphatidylinositol-specific phospholipase-C genes (PI-PLC)
EPL Molano, OG Cabrera, J Jose, LC do Nascimento, MF Carazzolle, ...
BMC genomics 19 (1), 1-24, 2018
312018
FragMAXapp: crystallographic fragment-screening data-analysis and project-management system
GMA Lima, E Jagudin, VO Talibov, LS Benz, C Marullo, T Barthel, ...
Acta Crystallographica Section D: Structural Biology 77 (6), 799-808, 2021
162021
Workflow and tools for crystallographic fragment screening at the Helmholtz-Zentrum Berlin
J Wollenhaupt, T Barthel, GMA Lima, A Metz, D Wallacher, E Jagudin, ...
JoVE (Journal of Visualized Experiments), e62208, 2021
152021
HTP-OligoDesigner: an online primer design tool for high-throughput gene cloning and site-directed mutagenesis
GMA Lima, CM Camilo, FV Maluf, RVC Guido, I Polikarpov
Journal of Computational Biology 23 (1), 27-29, 2016
142016
Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein–Protein Interaction Sites
T Barthel, J Wollenhaupt, GMA Lima, MC Wahl, MS Weiss
Journal of Medicinal Chemistry 65 (21), 14630-14641, 2022
112022
Crystal centering using deep learning in X-ray crystallography
J Schurmann, I Lindhè, JW Janneck, G Lima, Z Matej
2019 53rd Asilomar Conference on Signals, Systems, and Computers, 978-983, 2019
32019
Molecular Cloning and Biochemical Characterization of Iron Superoxide Dismutase from Leishmania braziliensis
CCB Brito, FV Maluf, GMA Lima, RVC Guido, MS Castilho
Molecular Biotechnology, 1-6, 2018
32018
Structural and molecular studies of xanthomonas albilineans phosphopantetheinyl transferase enzyme: molecular target for new agrochemicals development for sugarcane cultures
GMA Lima
Universidade de São Paulo, 2013
2*2013
FragMAX Facility for Crystallographic Fragment and Ligand Screening at MAX IV
S Kanchugal P, E Jagudin, GMA Lima, VO Talibov, A Begum, J Nan, ...
Applied Research 4 (1), e202400263, 2025
2025
Efficiently from library to hit–crystallographic fragment screening in Berlin via structurally diverse compound libraries
J Wollenhaupt, T Barthel, A Metz, GMA Lima, D Wallacher, E Jagudin, ...
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 77, C568-C568, 2021
2021
Hundreds of starting points for spliceosomal PPI modulators identified by crystallographic fragment screening with the F2X-Universal Library
T Barthel, J Wollenhaupt, GMA Lima, MC Wahl, MS Weiss
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 77, C1192-C1192, 2021
2021
Automated ML-based sample centering for macromolecular X-ray crystallography with MXAimbot
I Lindhé, Z Matej, G Lima, J Nan, M Egurian, A Gonzales, E Jagudin, ...
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 77, C148-C148, 2021
2021
Structural studies of folate biosynthesis pathway enzymes from Xanthomonas albilineans for the development of new agrochemical candidates for sugarcane crop
GMA de Lima
University of São Paulo, 2018
2018
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