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Francis A. Ortega
Francis A. Ortega
Tignis | Weill Cornell Medical College
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Cell-specific cardiac electrophysiology models
W Groenendaal, FA Ortega, AR Kherlopian, AC Zygmunt, ...
PLoS computational biology 11 (4), e1004242, 2015
1192015
Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytes
CT Bot, AR Kherlopian, FA Ortega, DJ Christini, T Krogh-Madsen
Frontiers in physiology 3, 421, 2012
442012
Global optimization of ventricular myocyte model to multi-variable objective improves predictions of drug-induced torsades de pointes
T Krogh-Madsen, AF Jacobson, FA Ortega, DJ Christini
Frontiers in Physiology 8, 1059, 2017
422017
Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility
RA Devenyi, FA Ortega, W Groenendaal, T Krogh‐Madsen, DJ Christini, ...
The Journal of physiology 595 (7), 2301-2317, 2017
412017
Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes
W Groenendaal, FA Ortega, T Krogh-Madsen, DJ Christini
Biophysical journal 106 (10), 2222-2232, 2014
342014
Dynamic clamp in cardiac and neuronal systems using RTXI
FA Ortega, RJ Butera, DJ Christini, JA White, AD Dorval
Patch-Clamp Methods and Protocols, 327-354, 2014
292014
Applications of dynamic clamp to cardiac arrhythmia research: Role in drug target discovery and safety pharmacology testing
FA Ortega, E Grandi, T Krogh-Madsen, DJ Christini
Frontiers in Physiology 8, 1099, 2018
242018
A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity
SY Tsai, Z Ghazizadeh, HJ Wang, S Amin, FA Ortega, ZS Badieyan, ...
Cardiovascular research 116 (3), 658-670, 2020
222020
DeepFocus: a deep learning model for focusing microscope systems
T Ivanov, A Kumar, D Sharoukhov, F Ortega, M Putman
Applications of machine learning 2020 11511, 1151103, 2020
142020
Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes
K Brown, S Legros, FA Ortega, Y Dai, MX Doss, DJ Christini, ...
PloS one 12 (12), e0189818, 2017
142017
Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia
N Gaur, F Ortega, AO Verkerk, I Mengarelli, T Krogh-Madsen, DJ Christini, ...
Journal of molecular and cellular cardiology 145, 122-132, 2020
122020
Cardiac myocyte model parameter sensitivity analysis and model transformation using a genetic algorithm
AR Kherlopian, FA Ortega, DJ Christini
Proceedings of the 13th annual conference companion on Genetic and …, 2011
92011
A dual SHOX2: GFP; MYH6: mCherry knockin hESC reporter line for derivation of human SAN-like cells
Z Ghazizadeh, J Zhu, F Fattahi, A Tang, X Sun, S Amin, SY Tsai, M Khalaj, ...
Iscience 25 (4), 2022
62022
Reevaluation of missed lung cancer with artificial intelligence
S Sicular, M Alpaslan, FA Ortega, N Keathley, S Venkatesh, RM Jones, ...
Respiratory Medicine Case Reports 39, 101733, 2022
42022
DeepDenoise: a deep learning model for noise reduction in low SNR imaging conditions
T Ivanov, A Kumar, D Sharoukhov, F Ortega, M Putman
Applications of Machine Learning 2020 11511, 20-28, 2020
22020
Learnings from Multiple Implementations of Closed Loop AI/ML Controllers for Semiconductor Manufacturing
FA Ortega, E Holzer, M Faria, J Herlocker
International Conference on Compound Semiconductor Manufacturing Technology, 2023
2023
Uncovering cardiac repolarization mechanisms through global optimization to dynamic electrophysiological protocols
FA Ortega
Weill Cornell, 2019
2019
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