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Jay Penney
Jay Penney
Canada Research Chair in Biomedical Genetics, University of Prince Edward Island
Adresse e-mail validée de upei.ca - Page d'accueil
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APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types
YT Lin, J Seo, F Gao, HM Feldman, HL Wen, J Penney, HP Cam, ...
Neuron 98 (6), 1141-1154. e7, 2018
10602018
The road to restoring neural circuits for the treatment of Alzheimer's disease
RG Canter, J Penney, LH Tsai
Nature 539 (7628), 187-196, 2016
5992016
Modeling Alzheimer’s disease with iPSC-derived brain cells
J Penney, WT Ralvenius, LH Tsai
Molecular psychiatry 25 (1), 148-167, 2020
4452020
Histone deacetylases in memory and cognition
J Penney, LH Tsai
Science signaling 7 (355), re12-re12, 2014
2012014
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
PC Pao, D Patnaik, LA Watson, F Gao, L Pan, J Wang, C Adaikkan, ...
Nature communications 11 (1), 2484, 2020
1612020
Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia
J Seo, O Kritskiy, LA Watson, SJ Barker, D Dey, WK Raja, YT Lin, T Ko, ...
Journal of Neuroscience 37 (41), 9917-9924, 2017
1472017
TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction
J Penney, K Tsurudome, EH Liao, F Elazzouzi, M Livingstone, ...
Neuron 74 (1), 166-178, 2012
1122012
The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction
K Tsurudome, K Tsang, EH Liao, R Ball, J Penney, JS Yang, F Elazzouzi, ...
Neuron 68 (5), 879-893, 2010
1002010
The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons
H Yamakawa, J Cheng, J Penney, F Gao, R Rueda, J Wang, ...
Cell reports 20 (6), 1319-1334, 2017
942017
Chromatin regulation of DNA damage repair and genome integrity in the central nervous system
L Pan, J Penney, LH Tsai
Journal of molecular biology 426 (20), 3376-3388, 2014
552014
LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
J Penney, K Tsurudome, EH Liao, G Kauwe, L Gray, A Yanagiya, ...
Nature communications 7 (1), 12188, 2016
482016
Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction
C Merino, J Penney, M González, K Tsurudome, M Moujahidine, ...
Journal of cell biology 185 (4), 713-725, 2009
462009
Loss of protein arginine methyltransferase 8 alters synapse composition and function, resulting in behavioral defects
J Penney, J Seo, O Kritskiy, S Elmsaouri, F Gao, PC Pao, SC Su, LH Tsai
Journal of Neuroscience 37 (36), 8655-8666, 2017
412017
Acute fasting regulates retrograde synaptic enhancement through a 4E-BP-dependent mechanism
G Kauwe, K Tsurudome, J Penney, M Mori, L Gray, MR Calderon, ...
Neuron 92 (6), 1204-1212, 2016
352016
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
PC Pao, J Seo, A Lee, O Kritskiy, D Patnaik, J Penney, RM Raju, ...
Proceedings of the National Academy of Sciences 120 (16), e2217864120, 2023
272023
Senescence mediates neurodegeneration
J Penney, LH Tsai
Nature 562 (7728), 503-504, 2018
27*2018
Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration
N Morshed, WT Ralvenius, A Nott, LA Watson, FH Rodriguez, LA Akay, ...
Molecular Systems Biology 16 (12), e9819, 2020
262020
Nanoparticle‐mediated delivery of Anti‐PU. 1 siRNA via localized intracisternal administration reduces neuroinflammation
WT Ralvenius, JL Andresen, MM Huston, J Penney, JM Bonner, ...
Advanced Materials 36 (8), 2309225, 2024
242024
iPSC‐derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss
J Penney, WT Ralvenius, A Loon, O Cerit, V Dileep, B Milo, PC Pao, ...
Glia 72 (2), 452-469, 2024
172024
A novel molecular class that recruits HDAC/MECP2 complexes to PU. 1 motifs reduces neuroinflammation
WT Ralvenius, AE Mungenast, H Woolf, MM Huston, TZ Gillingham, ...
Journal of Experimental Medicine 220 (11), e20222105, 2023
112023
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