APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types YT Lin, J Seo, F Gao, HM Feldman, HL Wen, J Penney, HP Cam, ... Neuron 98 (6), 1141-1154. e7, 2018 | 1060 | 2018 |
The road to restoring neural circuits for the treatment of Alzheimer's disease RG Canter, J Penney, LH Tsai Nature 539 (7628), 187-196, 2016 | 599 | 2016 |
Modeling Alzheimer’s disease with iPSC-derived brain cells J Penney, WT Ralvenius, LH Tsai Molecular psychiatry 25 (1), 148-167, 2020 | 445 | 2020 |
Histone deacetylases in memory and cognition J Penney, LH Tsai Science signaling 7 (355), re12-re12, 2014 | 201 | 2014 |
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease PC Pao, D Patnaik, LA Watson, F Gao, L Pan, J Wang, C Adaikkan, ... Nature communications 11 (1), 2484, 2020 | 161 | 2020 |
Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia J Seo, O Kritskiy, LA Watson, SJ Barker, D Dey, WK Raja, YT Lin, T Ko, ... Journal of Neuroscience 37 (41), 9917-9924, 2017 | 147 | 2017 |
TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction J Penney, K Tsurudome, EH Liao, F Elazzouzi, M Livingstone, ... Neuron 74 (1), 166-178, 2012 | 112 | 2012 |
The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction K Tsurudome, K Tsang, EH Liao, R Ball, J Penney, JS Yang, F Elazzouzi, ... Neuron 68 (5), 879-893, 2010 | 100 | 2010 |
The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons H Yamakawa, J Cheng, J Penney, F Gao, R Rueda, J Wang, ... Cell reports 20 (6), 1319-1334, 2017 | 94 | 2017 |
Chromatin regulation of DNA damage repair and genome integrity in the central nervous system L Pan, J Penney, LH Tsai Journal of molecular biology 426 (20), 3376-3388, 2014 | 55 | 2014 |
LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction J Penney, K Tsurudome, EH Liao, G Kauwe, L Gray, A Yanagiya, ... Nature communications 7 (1), 12188, 2016 | 48 | 2016 |
Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction C Merino, J Penney, M González, K Tsurudome, M Moujahidine, ... Journal of cell biology 185 (4), 713-725, 2009 | 46 | 2009 |
Loss of protein arginine methyltransferase 8 alters synapse composition and function, resulting in behavioral defects J Penney, J Seo, O Kritskiy, S Elmsaouri, F Gao, PC Pao, SC Su, LH Tsai Journal of Neuroscience 37 (36), 8655-8666, 2017 | 41 | 2017 |
Acute fasting regulates retrograde synaptic enhancement through a 4E-BP-dependent mechanism G Kauwe, K Tsurudome, J Penney, M Mori, L Gray, MR Calderon, ... Neuron 92 (6), 1204-1212, 2016 | 35 | 2016 |
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes PC Pao, J Seo, A Lee, O Kritskiy, D Patnaik, J Penney, RM Raju, ... Proceedings of the National Academy of Sciences 120 (16), e2217864120, 2023 | 27 | 2023 |
Senescence mediates neurodegeneration J Penney, LH Tsai Nature 562 (7728), 503-504, 2018 | 27* | 2018 |
Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration N Morshed, WT Ralvenius, A Nott, LA Watson, FH Rodriguez, LA Akay, ... Molecular Systems Biology 16 (12), e9819, 2020 | 26 | 2020 |
Nanoparticle‐mediated delivery of Anti‐PU. 1 siRNA via localized intracisternal administration reduces neuroinflammation WT Ralvenius, JL Andresen, MM Huston, J Penney, JM Bonner, ... Advanced Materials 36 (8), 2309225, 2024 | 24 | 2024 |
iPSC‐derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss J Penney, WT Ralvenius, A Loon, O Cerit, V Dileep, B Milo, PC Pao, ... Glia 72 (2), 452-469, 2024 | 17 | 2024 |
A novel molecular class that recruits HDAC/MECP2 complexes to PU. 1 motifs reduces neuroinflammation WT Ralvenius, AE Mungenast, H Woolf, MM Huston, TZ Gillingham, ... Journal of Experimental Medicine 220 (11), e20222105, 2023 | 11 | 2023 |