| TGF‐β signaling and the fibrotic response A Leask, DJ Abraham The FASEB Journal 18 (7), 816-827, 2004 | 3068 | 2004 |
| Potential therapeutic targets for cardiac fibrosis: TGFβ, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation A Leask Circulation research 106 (11), 1675-1680, 2010 | 881 | 2010 |
| All in the CCN family: essential matricellular signaling modulators emerge from the bunker A Leask, DJ Abraham Journal of cell science 119 (23), 4803-4810, 2006 | 754 | 2006 |
| CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling A Holmes, DJ Abraham, S Sa, X Shiwen, CM Black, A Leask Journal of Biological Chemistry 276 (14), 10594-10601, 2001 | 592 | 2001 |
| Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? IE Blom, R Goldschmeding, A Leask Matrix Biology 21 (6), 473-482, 2002 | 540 | 2002 |
| Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis X Shi-Wen, A Leask, D Abraham Cytokine & growth factor reviews 19 (2), 133-144, 2008 | 488 | 2008 |
| Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile … X Shi-Wen, Y Chen, CP Denton, M Eastwood, EA Renzoni, ... Molecular biology of the cell 15 (6), 2707-2719, 2004 | 460 | 2004 |
| Alopecia Universalis Associated with a Mutation in the Human hairless Gene W Ahmad, M Faiyaz ul Haque, V Brancolini, HC Tsou, S Ul Haque, ... Science 279 (5351), 720-724, 1998 | 427 | 1998 |
| Connective tissue growth factor gene regulation: requirements for its induction by transforming growth factor-β2 in fibroblasts A Leask, A Holmes, CM Black, DJ Abraham Journal of Biological Chemistry 278 (15), 13008-13015, 2003 | 417 | 2003 |
| TGFβ, cardiac fibroblasts, and the fibrotic response A Leask Cardiovascular research 74 (2), 207-212, 2007 | 411 | 2007 |
| The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology A Leask, DJ Abraham Biochemistry and Cell Biology 81 (6), 355-363, 2003 | 401 | 2003 |
| Getting to the heart of the matter: new insights into cardiac fibrosis A Leask Circulation research 116 (7), 1269-1276, 2015 | 396 | 2015 |
| Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts DJ Abraham, X Shiwen, CM Black, S Sa, Y Xu, A Leask Journal of Biological Chemistry 275 (20), 15220-15225, 2000 | 390 | 2000 |
| Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair J Duan, C Gherghe, D Liu, E Hamlett, L Srikantha, L Rodgers, JN Regan, ... The EMBO journal 31 (2), 429-442, 2012 | 369 | 2012 |
| Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis A Leask, A Holmes, DJ Abraham Current rheumatology reports 4 (2), 136-142, 2002 | 339 | 2002 |
| CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC Y Chen, IE Blom, S Sa, R Goldschmeding, DJ Abraham, A Leask Kidney international 62 (4), 1149-1159, 2002 | 326 | 2002 |
| Pivotal role of connective tissue growth factor in lung fibrosis: MAPK‐dependent transcriptional activation of type I collagen M Ponticos, AM Holmes, X Shi‐Wen, P Leoni, K Khan, VS Rajkumar, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 283 | 2009 |
| Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients R Stratton, X Shiwen, G Martini, A Holmes, A Leask, T Haberberger, ... The Journal of clinical investigation 108 (2), 241-250, 2001 | 276 | 2001 |
| Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis X Shi-Wen, D Pennington, A Holmes, A Leask, D Bradham, ... Experimental cell research 259 (1), 213-224, 2000 | 274 | 2000 |
| Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis S Sonnylal, X Shi‐Wen, P Leoni, K Naff, CS Van Pelt, H Nakamura, ... Arthritis & Rheumatism 62 (5), 1523-1532, 2010 | 250 | 2010 |
George Bou-GhariosProfessor of Matrix BiologyAdresse e-mail validée de liverpool.ac.uk
