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| Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space EK Makowski, PC Kinnunen, J Huang, L Wu, MD Smith, T Wang, ... Nature communications 13 (1), 3788, 2022 | 115 | 2022 |
| Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning EK Makowski, T Wang, JM Zupancic, J Huang, L Wu, JS Schardt, ... Nature Biomedical Engineering 8 (1), 45-56, 2024 | 23 | 2024 |
| Characterization of intact glycopeptides reveals the impact of culture media on site‐specific glycosylation of EPO‐Fc fusion protein generated by CHO‐GS cells Q Wang, G Yang, T Wang, W Yang, MJ Betenbaugh, H Zhang Biotechnology and bioengineering 116 (9), 2303-2315, 2019 | 16 | 2019 |
| The interplay of protein engineering and glycoengineering to fine‐tune antibody glycosylation and its impact on effector functions Q Wang, T Wang, R Zhang, S Yang, KS McFarland, CY Chung, H Jia, ... Biotechnology and bioengineering 119 (1), 102-117, 2022 | 13 | 2022 |
| Reduction of monoclonal antibody viscosity using interpretable machine learning EK Makowski, HT Chen, T Wang, L Wu, J Huang, M Mock, P Underhill, ... Mabs 16 (1), 2303781, 2024 | 10 | 2024 |
| Metabolic engineering challenges of extending N-glycan pathways in Chinese hamster ovary cells Q Wang, T Wang, S Yang, S Sha, WW Wu, Y Chen, JT Paul, RF Shen, ... Metabolic Engineering 61, 301-314, 2020 | 10 | 2020 |
| Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space. Nat. Commun. 13, 3788 EK Makowski, PC Kinnunen, J Huang, L Wu, MD Smith, T Wang, ... | 8 | 2022 |
| Comprehensive N-and O-glycoproteomic analysis of multiple Chinese hamster ovary host cell lines Q Wang, T Wang, WW Wu, CY Lin, S Yang, G Yang, E Jankowska, Y Hu, ... Journal of Proteome Research 21 (10), 2341-2355, 2022 | 6 | 2022 |
| Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures HM Naik, S Kumar, JV Reddy, JE Gonzalez, BO McConnell, VG Dhara, ... Biotechnology and Bioengineering 120 (9), 2559-2577, 2023 | 5 | 2023 |
| In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies A Kopp, S Dong, H Kwon, T Wang, AA Desai, JJ Linderman, P Tessier, ... bioRxiv, 2024 | | 2024 |
