| Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates JE Dunford, K Thompson, FP Coxon, SP Luckman, FM Hahn, CD Poulter, ... Journal of Pharmacology and Experimental Therapeutics 296 (2), 235-242, 2001 | 1231 | 2001 |
| The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs KL Kavanagh, K Guo, JE Dunford, X Wu, S Knapp, FH Ebetino, ... Proceedings of the National Academy of Sciences 103 (20), 7829-7834, 2006 | 675 | 2006 |
| Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy RGG Russell, Z Xia, JE Dunford, UDO Oppermann, A Kwaasi, PA Hulley, ... Annals of the New York Academy of Sciences 1117 (1), 209-257, 2007 | 542 | 2007 |
| The relationship between the chemistry and biological activity of the bisphosphonates FH Ebetino, AML Hogan, S Sun, MK Tsoumpra, X Duan, JT Triffitt, ... Bone 49 (1), 20-33, 2011 | 494 | 2011 |
| Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases JE Dunford, MJ Rogers, FH Ebetino, RJ Phipps, FP Coxon Journal of bone and mineral research 21 (5), 684-694, 2006 | 245 | 2006 |
| Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages FP Coxon, MH Helfrich, B Larijani, M Muzylak, JE Dunford, D Marshall, ... Journal of Biological Chemistry 276 (51), 48213-48222, 2001 | 209 | 2001 |
| Structure–activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate … JE Dunford, AA Kwaasi, MJ Rogers, BL Barnett, FH Ebetino, RGG Russell, ... Journal of medicinal chemistry 51 (7), 2187-2195, 2008 | 197 | 2008 |
| The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding KL Kavanagh, JE Dunford, G Bunkoczi, RGG Russell, U Oppermann Journal of biological chemistry 281 (31), 22004-22012, 2006 | 186 | 2006 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of medicinal chemistry 55 (14), 6639-6643, 2012 | 171 | 2012 |
| Modulation of osteoclastogenesis by fatty acids J Cornish, A MacGibbon, JM Lin, M Watson, KE Callon, PC Tong, ... Endocrinology 149 (11), 5688-5695, 2008 | 159 | 2008 |
| Differences between bisphosphonates in binding affinities for hydroxyapatite MA Lawson, Z Xia, BL Barnett, JT Triffitt, RJ Phipps, JE Dunford, ... Journal of Biomedical Materials Research Part B: Applied Biomaterials: An …, 2010 | 143 | 2010 |
| Synthesis and biological evaluation of α-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate MS Marma, Z Xia, C Stewart, F Coxon, JE Dunford, R Baron, ... Journal of medicinal chemistry 50 (24), 5967-5975, 2007 | 102 | 2007 |
| Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming A Ebrahimi, K Sevinç, G Gürhan Sevinç, AP Cribbs, M Philpott, F Uyulur, ... Nature chemical biology 15 (5), 519-528, 2019 | 100 | 2019 |
| Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a γδ-T lymphocytes-mediated activation mechanism D Simoni, N Gebbia, FP Invidiata, M Eleopra, P Marchetti, R Rondanin, ... Journal of medicinal chemistry 51 (21), 6800-6807, 2008 | 96 | 2008 |
| Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity SM Yang, NJ Martinez, A Yasgar, C Danchik, C Johansson, Y Wang, ... Journal of medicinal chemistry 61 (11), 4883-4903, 2018 | 88 | 2018 |
| Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase K Thompson, JE Dunford, FH Ebetino, MJ Rogers Biochemical and biophysical research communications 290 (2), 869-873, 2002 | 74 | 2002 |
| GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates N Roca-Ayats, S Balcells, N Garcia-Giralt, M Falco-Mascaro, ... New England Journal of Medicine 376 (18), 1794-1795, 2017 | 73 | 2017 |
| Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo [1 … CE McKenna, BA Kashemirov, KM Błażewska, I Mallard-Favier, ... Journal of medicinal chemistry 53 (9), 3454-3464, 2010 | 73 | 2010 |
| Structural basis for substrate specificity in human monomeric carbonyl reductases ES Pilka, FH Niesen, WH Lee, Y El-Hawari, JE Dunford, G Kochan, ... PLoS One 4 (10), e7113, 2009 | 69 | 2009 |
| Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites JD Artz, AK Wernimont, JE Dunford, M Schapira, A Dong, Y Zhao, J Lew, ... Journal of biological chemistry 286 (5), 3315-3322, 2011 | 68 | 2011 |
