| Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease SS Xie, XB Wang, JY Li, L Yang, LY Kong European journal of medicinal chemistry 64, 540-553, 2013 | 199 | 2013 |
| Formation of alpha-chiral centers by asymmetric beta-C(sp3)-H arylation, alkenylation, and alkynylation QF Wu, PX Shen, J He, XB Wang, F Zhang, Q Shao, RY Zhu, C Mapelli, ... Science 355, 499-503, 2017 | 194 | 2017 |
| Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease SS Xie, X Wang, N Jiang, W Yu, KDG Wang, JS Lan, ZR Li, LY Kong European Journal of Medicinal Chemistry 95, 153-165, 2015 | 192 | 2015 |
| Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues X Zhou, XB Wang, T Wang, LY Kong Bioorganic & medicinal chemistry 16 (17), 8011-8021, 2008 | 185 | 2008 |
| Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease SY Li, XB Wang, LY Kong European journal of medicinal chemistry 71, 36-45, 2014 | 127 | 2014 |
| Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer’s disease RS Li, XB Wang, XJ Hu, LY Kong Bioorganic & medicinal chemistry letters 23 (9), 2636-2641, 2013 | 111 | 2013 |
| Multifunctional tacrine–flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease SY Li, XB Wang, SS Xie, N Jiang, KDG Wang, HQ Yao, HB Sun, LY Kong European Journal of Medicinal Chemistry 69, 632-646, 2013 | 108 | 2013 |
| Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties SS Xie, JS Lan, XB Wang, N Jiang, G Dong, ZR Li, KDG Wang, PP Guo, ... European journal of medicinal chemistry 93, 42-50, 2015 | 100 | 2015 |
| Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease SS Xie, JS Lan, X Wang, ZM Wang, N Jiang, F Li, JJ Wu, J Wang, ... Bioorganic & Medicinal Chemistry 24 (7), 1528-1539, 2016 | 93 | 2016 |
| Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease SY Li, N Jiang, SS Xie, KDG Wang, XB Wang, LY Kong Organic & biomolecular chemistry 12 (5), 801-814, 2014 | 91 | 2014 |
| Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer’s disease JS Lan, SS Xie, SY Li, LF Pan, XB Wang, LY Kong Bioorganic & medicinal chemistry 22 (21), 6089-6104, 2014 | 90 | 2014 |
| Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease M Huang, SS Xie, N Jiang, JS Lan, LY Kong, XB Wang Bioorganic & medicinal chemistry letters 25 (3), 508-513, 2015 | 86 | 2015 |
| Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin J Wang, ZM Wang, XM Li, F Li, JJ Wu, LY Kong, XB Wang Bioorganic & medicinal chemistry 24 (18), 4324-4338, 2016 | 83 | 2016 |
| Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease ZM Wang, P Cai, QH Liu, DQ Xu, XL Yang, JJ Wu, LY Kong, XB Wang European Journal of Medicinal Chemistry 123, 282-297, 2016 | 81 | 2016 |
| Enantioselective C–H Arylation and Vinylation of Cyclobutyl Carboxylic Amides QF Wu, XB Wang, PX Shen, JQ and Yu ACS Catalysis 8, 2577-2581, 2018 | 73 | 2018 |
| Novel 8-hydroxyquinoline derivatives targeting β-amyloid aggregation, metal chelation and oxidative stress against Alzheimer’s disease X Yang, P Cai, Q Liu, J Wu, Y Yin, X Wang, L Kong Bioorganic & Medicinal Chemistry 26 (12), 3191-3201, 2018 | 68 | 2018 |
| Development of a tau-targeted drug delivery system using a multifunctional nanoscale metal–organic framework for Alzheimer’s disease therapy J Zhao, F Yin, L Ji, C Wang, C Shi, X Liu, H Yang, X Wang, L Kong ACS applied materials & interfaces 12 (40), 44447-44458, 2020 | 62 | 2020 |
| Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid- β aggregation for the treatment of Alzheimer's disease. HL Yang, P Cai, QH Liu, XL Yang, F Li, J Wang, JJ Wu, XB Wang, ... European Journal of Medicinal Chemistry, 138, 715-728, 2017 | 62 | 2017 |
| Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer’s disease F Li, ZM Wang, JJ Wu, J Wang, SS Xie, JS Lan, W Xu, LY Kong, XB Wang Journal of enzyme inhibition and medicinal chemistry 31 (sup3), 41-53, 2016 | 61 | 2016 |
| Automatic authentication and distinction of Epimedium koreanum and Epimedium wushanense with HPLC fingerprint analysis assisted by pattern recognition techniques L Wang, X Wang, L Kong Biochemical Systematics and Ecology 40, 138-145, 2012 | 59 | 2012 |
jin-quan yuProfessor of Chemistry, The Scripps Research InstituteAdresse e-mail validée de scripps.edu