| Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade N McGranahan, AJS Furness, R Rosenthal, S Ramskov, R Lyngaa, ... Science 351 (6280), 1463-1469, 2016 | 3182 | 2016 |
| Tracking the evolution of non–small-cell lung cancer M Jamal-Hanjani, GA Wilson, N McGranahan, NJ Birkbak, TBK Watkins, ... New England Journal of Medicine 376 (22), 2109-2121, 2017 | 2379 | 2017 |
| Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ... Nature 545 (7655), 446-451, 2017 | 1850 | 2017 |
| Chromosomal instability drives metastasis through a cytosolic DNA response SF Bakhoum, B Ngo, AM Laughney, JA Cavallo, CJ Murphy, P Ly, P Shah, ... Nature 553 (7689), 467-472, 2018 | 1380 | 2018 |
| Allele-specific HLA loss and immune escape in lung cancer evolution N McGranahan, R Rosenthal, CT Hiley, AJ Rowan, TBK Watkins, ... Cell 171 (6), 1259-1271. e11, 2017 | 1296 | 2017 |
| Tracking cancer evolution reveals constrained routes to metastases: TRACERx renal S Turajlic, H Xu, K Litchfield, A Rowan, T Chambers, JI Lopez, D Nicol, ... Cell 173 (3), 581-594. e12, 2018 | 778 | 2018 |
| Meta-analysis of tumor-and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition K Litchfield, JL Reading, C Puttick, K Thakkar, C Abbosh, R Bentham, ... Cell 184 (3), 596-614. e14, 2021 | 704 | 2021 |
| Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal S Turajlic, H Xu, K Litchfield, A Rowan, S Horswell, T Chambers, ... Cell 173 (3), 595-610. e11, 2018 | 620 | 2018 |
| Fc effector function contributes to the activity of human anti-CTLA-4 antibodies FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ... Cancer cell 33 (4), 649-663. e4, 2018 | 594 | 2018 |
| Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations TF Eleveld, DA Oldridge, V Bernard, J Koster, LC Daage, SJ Diskin, ... Nature genetics 47 (8), 864-871, 2015 | 590 | 2015 |
| Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers CM Blakely, TBK Watkins, W Wu, B Gini, JJ Chabon, CE McCoach, ... Nature genetics 49 (12), 1693-1704, 2017 | 517 | 2017 |
| Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ... Immunity 46 (4), 577-586, 2017 | 454 | 2017 |
| Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes SC Dentro, I Leshchiner, K Haase, M Tarabichi, J Wintersinger, ... Cell 184 (8), 2239-2254. e39, 2021 | 376 | 2021 |
| Pervasive chromosomal instability and karyotype order in tumour evolution TBK Watkins, EL Lim, M Petkovic, S Elizalde, NJ Birkbak, GA Wilson, ... Nature 587 (7832), 126-132, 2020 | 331 | 2020 |
| Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy N Murugaesu, GA Wilson, NJ Birkbak, TBK Watkins, N McGranahan, ... Cancer discovery 5 (8), 821-831, 2015 | 268 | 2015 |
| Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution S López, EL Lim, S Horswell, K Haase, A Huebner, M Dietzen, ... Nature genetics 52 (3), 283-293, 2020 | 225 | 2020 |
| Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA C Abbosh, AM Frankell, T Harrison, J Kisistok, A Garnett, L Johnson, ... Nature 616 (7957), 553-562, 2023 | 173 | 2023 |
| The evolution of lung cancer and impact of subclonal selection in TRACERx AM Frankell, M Dietzen, M Al Bakir, EL Lim, T Karasaki, S Ward, ... Nature 616 (7957), 525-533, 2023 | 167 | 2023 |
| Antibodies against endogenous retroviruses promote lung cancer immunotherapy KW Ng, J Boumelha, KSS Enfield, J Almagro, H Cha, O Pich, T Karasaki, ... Nature 616 (7957), 563-573, 2023 | 152 | 2023 |
| The National Lung Matrix Trial of personalized therapy in lung cancer G Middleton, P Fletcher, S Popat, J Savage, Y Summers, A Greystoke, ... Nature 583 (7818), 807-812, 2020 | 151 | 2020 |
Charles SwantonFrancis Crick InstituteAdresse e-mail validée de crick.ac.uk
