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Mariela Jaskelioff
Mariela Jaskelioff
Vicepresident at Curie.Bio
Adresse e-mail validée de curie.bio
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Telomere dysfunction induces metabolic and mitochondrial compromise
E Sahin, S Colla, M Liesa, J Moslehi, FL Müller, M Guo, M Cooper, ...
Nature 470 (7334), 359-365, 2011
14542011
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
M Jaskelioff, FL Muller, JH Paik, E Thomas, S Jiang, AC Adams, E Sahin, ...
Nature 469 (7328), 102-106, 2011
10522011
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
GR Hoffman, R Rahal, F Buxton, K Xiang, G McAllister, E Frias, ...
Proceedings of the National Academy of Sciences 111 (8), 3128-3133, 2014
4512014
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer
J Hu, SS Hwang, M Liesa, B Gan, E Sahin, M Jaskelioff, Z Ding, H Ying, ...
Cell 148 (4), 651-663, 2012
3532012
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases
Z Ding, CJ Wu, M Jaskelioff, E Ivanova, M Kost-Alimova, A Protopopov, ...
Cell 148 (5), 896-907, 2012
2612012
Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin
M Jaskelioff, S Van Komen, JE Krebs, P Sung, CL Peterson
Journal of Biological Chemistry 278 (11), 9212-9218, 2003
2372003
Proinvasion metastasis drivers in early-stage melanoma are oncogenes
KL Scott, C Nogueira, TP Heffernan, R van Doorn, S Dhakal, JA Hanna, ...
Cancer cell 20 (1), 92-103, 2011
1702011
SWI-SNF-mediated nucleosome remodeling: role of histone octamer mobility in the persistence of the remodeled state
M Jaskelioff, I M. Gavin, CL Peterson, C Logie
Molecular and cellular biology 20 (9), 3058-3068, 2000
1492000
Chromatin and transcription: histones continue to make their marks
M Jaskelioff, CL Peterson
Nature cell biology 5 (5), 395-399, 2003
1092003
Hyperactivation of MAPK signaling is deleterious to RAS/RAF-mutant melanoma
GP Leung, T Feng, FD Sigoillot, FC Geyer, MD Shirley, DA Ruddy, ...
Molecular Cancer Research 17 (1), 199-211, 2019
642019
LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors
KA Monaco, S Delach, J Yuan, Y Mishina, P Fordjour, E Labrot, D McKay, ...
Clinical cancer research 27 (7), 2061-2073, 2021
622021
Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene
M Jaskelioff, W Song, J Xia, C Liu, J Kramer, S Koido, SJ Gendler, ...
Oncogene 28 (48), 4225-4236, 2009
302009
In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling
Z Jagani, G Chenail, K Xiang, G Bushold, HEC Bhang, A Li, GN Elliott, ...
Biorxiv, 812628, 2019
112019
Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer
T Shingu, M Jaskelioff, L Yuan, Z Ding, A Protopopov, M Kost-Alimova, ...
Journal of visualized experiments: JoVE, 52599, 2015
52015
Abstract LB-114: RAF inhibitor LXH254 effectively inhibits B-and-CRAF, but not ARAF
KA Monaco, S Delach, P Fordjour, S Parikh, Y Feng, M Jaskelioff, D Stuart, ...
Cancer Research 79 (13_Supplement), LB-114-LB-114, 2019
42019
Genome unstable murine prostate cancers acquire genomic aberrations and bone metastatic features of the human disease
Z Ding, CJ Wu, M Jaskelioff, E Ivanova, M Kost-Alimova, A Protopopov, ...
Cell 148 (5), 896, 2012
22012
Quantification of telomere length by FISH and laser scanning cytometry
JE Mahoney, E Sahin, M Jaskelioff, L Chin, RA DePinho, AI Protopopov
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI …, 2008
12008
Postdoc Mentor Profile
M Jaskelioff
https://www. novartis. com/our-science/postdoc-program, 2019
2019
Deleterious effects of MAPK pathway hyperactivation in BRAF-mutant melanoma
GP Leung, T Feng, MD Shirley, FD Sigoillot, DA Ruddy, AK Freeman, ...
Cancer Research 78 (13_Supplement), 965-965, 2018
2018
Markers for ezh2 inhibitors
HM Chan, V Gibaja, K Haas, J Jaffe, M Jaskelioff, FP Stegmeier, W Qi
US Patent App. 14/785,594, 2016
2016
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