| Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial DB Keskin, AJ Anandappa, J Sun, I Tirosh, ND Mathewson, S Li, ... Nature 565 (7738), 234-239, 2019 | 1273 | 2019 |
| Mechanisms and therapeutic implications of hypermutation in gliomas M Touat, YY Li, AN Boynton, LF Spurr, JB Iorgulescu, CL Bohrson, ... Nature 580 (7804), 517-523, 2020 | 556 | 2020 |
| Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome … I Laufer, JB Iorgulescu, T Chapman, E Lis, W Shi, Z Zhang, BW Cox, ... Journal of Neurosurgery: Spine 18 (3), 207-214, 2013 | 517 | 2013 |
| Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma Z Hu, DE Leet, RL Allesøe, G Oliveira, S Li, AM Luoma, J Liu, J Forman, ... Nature medicine 27 (3), 515-525, 2021 | 408 | 2021 |
| Mitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies R Guièze, VM Liu, D Rosebrock, AA Jourdain, M Hernández-Sánchez, ... Cancer cell 36 (4), 369-384. e13, 2019 | 312 | 2019 |
| Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy SH Gohil, JB Iorgulescu, DA Braun, DB Keskin, KJ Livak Nature Reviews Clinical Oncology 18 (4), 244-256, 2021 | 230 | 2021 |
| The role of radiotherapy following gross-total resection of atypical meningiomas RJ Komotar, JB Iorgulescu, DMS Raper, EC Holland, K Beal, MH Bilsky, ... Journal of neurosurgery 117 (4), 679-686, 2012 | 197 | 2012 |
| Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding A Siu, JJ Wind, JB Iorgulescu, TA Chan, Y Yamada, JH Sherman Acta neurochirurgica 154, 191-201, 2012 | 171 | 2012 |
| Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery ME Ivan, JB Iorgulescu, I El-Sayed, MW McDermott, AT Parsa, ... Journal of clinical neuroscience 22 (1), 48-54, 2015 | 165 | 2015 |
| Concurrent dexamethasone limits the clinical benefit of immune checkpoint blockade in glioblastoma JB Iorgulescu, PC Gokhale, MC Speranza, BK Eschle, MJ Poitras, ... Clinical Cancer Research 27 (1), 276-287, 2021 | 135 | 2021 |
| Comparison of navigated versus non-navigated pedicle screw placement in 260 patients and 1434 screws: screw accuracy, screw size, and the complexity of surgery N Luther, JB Iorgulescu, C Geannette, H Gebhard, T Saleh, AJ Tsiouris, ... Clinical Spine Surgery 28 (5), E298-E303, 2015 | 133 | 2015 |
| Landscape of helper and regulatory antitumour CD4+ T cells in melanoma G Oliveira, K Stromhaug, N Cieri, JB Iorgulescu, S Klaeger, JO Wolff, ... Nature 605 (7910), 532-538, 2022 | 126 | 2022 |
| Molecular and clinical effects of notch inhibition in glioma patients: a phase 0/I trial R Xu, F Shimizu, K Hovinga, K Beal, S Karimi, L Droms, KK Peck, P Gutin, ... Clinical Cancer Research 22 (19), 4786-4796, 2016 | 122 | 2016 |
| The incidence and patterns of hardware failure after separation surgery in patients with spinal metastatic tumors NM Amankulor, R Xu, JB Iorgulescu, T Chapman, AS Reiner, E Riedel, ... The Spine Journal 14 (9), 1850-1859, 2014 | 111 | 2014 |
| Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacy: A review RJ Komotar, DMS Raper, RM Starke, JB Iorgulescu, PH Gutin Journal of neurosurgery 115 (3), 483-490, 2011 | 84 | 2011 |
| Slide-tags enables single-nucleus barcoding for multimodal spatial genomics AJC Russell, JA Weir, NM Nadaf, M Shabet, V Kumar, S Kambhampati, ... Nature 625 (7993), 101-109, 2024 | 79 | 2024 |
| Contemporary assessment of extent of resection in molecularly defined categories of diffuse low-grade glioma: a volumetric analysis VK Kavouridis, A Boaro, J Dorr, EY Cho, JB Iorgulescu, DA Reardon, ... Journal of neurosurgery 133 (5), 1291-1301, 2019 | 79 | 2019 |
| Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response S Liu, JB Iorgulescu, S Li, M Borji, IA Barrera-Lopez, V Shanmugam, ... Immunity 55 (10), 1940-1952. e5, 2022 | 76 | 2022 |
| Improved risk-adjusted survival for melanoma brain metastases in the era of checkpoint blockade immunotherapies: results from a national cohort JB Iorgulescu, M Harary, CK Zogg, KL Ligon, DA Reardon, FS Hodi, ... Cancer immunology research 6 (9), 1039-1045, 2018 | 74 | 2018 |
| Acquired mechanisms of immune escape in cancer following immunotherapy JB Iorgulescu, D Braun, G Oliveira, DB Keskin, CJ Wu Genome medicine 10, 1-4, 2018 | 70 | 2018 |
Keith L. LigonAssociate Professor, Harvard Medical SchoolAdresse e-mail validée de dfci.harvard.edu