| Cellular stress response pathway system as a sentinel ensemble in toxicological screening SO Simmons, CY Fan, R Ramabhadran Toxicological sciences 111 (2), 202-225, 2009 | 333 | 2009 |
| The next generation blueprint of computational toxicology at the US Environmental Protection Agency RS Thomas, T Bahadori, TJ Buckley, J Cowden, C Deisenroth, ... Toxicological Sciences 169 (2), 317-332, 2019 | 304 | 2019 |
| Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening CY Fan, J Cowden, SO Simmons, S Padilla, R Ramabhadran Neurotoxicology and teratology 32 (1), 91-98, 2010 | 193 | 2010 |
| Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells MJ Kesic, SO Simmons, R Bauer, I Jaspers Free Radical Biology and Medicine 51 (2), 444-453, 2011 | 179 | 2011 |
| Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches PD Noyes, KP Friedman, P Browne, JT Haselman, ME Gilbert, ... Environmental health perspectives 127 (9), 095001, 2019 | 164 | 2019 |
| High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death JT Fox, S Sakamuru, R Huang, N Teneva, SO Simmons, M Xia, RR Tice, ... Proceedings of the National Academy of Sciences 109 (14), 5423-5428, 2012 | 143 | 2012 |
| NRF2 oxidative stress induced by heavy metals is cell type dependent SO Simmons, CY Fan, K Yeoman, J Wakefield, R Ramabhadran Current chemical genomics 5, 1, 2011 | 142 | 2011 |
| Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast phase I and II chemical libraries K Paul Friedman, ED Watt, MW Hornung, JM Hedge, RS Judson, ... Toxicological Sciences 151 (1), 160-180, 2016 | 133 | 2016 |
| Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: effect of size, surface coating … RY Prasad, JK McGee, MG Killius, DA Suarez, CF Blackman, ... Toxicology in vitro 27 (6), 2013 | 126 | 2013 |
| Development of a thyroperoxidase inhibition assay for high-throughput screening KB Paul, JM Hedge, DM Rotroff, MW Hornung, KM Crofton, SO Simmons Chemical research in toxicology 27 (3), 387-399, 2014 | 106 | 2014 |
| Ambient particulate matter induces interleukin-8 expression through an alternative NF-κB (nuclear factor-kappa B) mechanism in human airway epithelial cells R Silbajoris, AR Osornio-Vargas, SO Simmons, W Reed, PA Bromberg, ... Environmental health perspectives 119 (10), 1379-1383, 2011 | 81 | 2011 |
| Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS) DR Hallinger, AS Murr, AR Buckalew, SO Simmons, TE Stoker, SC Laws Toxicology in vitro 40, 66-78, 2017 | 80 | 2017 |
| Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles TL Tal, SO Simmons, R Silbajoris, L Dailey, SH Cho, R Ramabhadran, ... Toxicology and applied pharmacology 243 (1), 46-54, 2010 | 76 | 2010 |
| High-throughput screening and quantitative chemical ranking for sodium-iodide symporter inhibitors in ToxCast phase I chemical library J Wang, DR Hallinger, AS Murr, AR Buckalew, SO Simmons, SC Laws, ... Environmental science & technology 52 (9), 5417-5426, 2018 | 63 | 2018 |
| Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors KB Paul, JT Thompson, SO Simmons, JPV Heuvel, KM Crofton Toxicology in vitro 27 (7), 2049-2060, 2013 | 55 | 2013 |
| Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach SJ Shukla, R Huang, SO Simmons, RR Tice, KL Witt, D VanLeer, ... Environmental health perspectives 120 (8), 1150-1156, 2012 | 54 | 2012 |
| Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat KB Paul, JM Hedge, C Macherla, DL Filer, E Burgess, SO Simmons, ... Toxicology 312, 97-107, 2013 | 51 | 2013 |
| Comparison of in vitro and in vivo bioassays to measure thyroid hormone disrupting activity in water extracts FDL Leusch, NH Aneck-Hahn, JAE Cavanagh, D Du Pasquier, T Hamers, ... Chemosphere 191, 868-875, 2018 | 48 | 2018 |
| Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component WY Cheng, J Currier, PA Bromberg, R Silbajoris, SO Simmons, JM Samet Environmental Health Perspectives 120 (2), 267-274, 2012 | 46 | 2012 |
| Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism ML Spengler, SB Kennett, KS Moorefield, SO Simmons, MG Brattain, ... Cellular signalling 17 (2), 153-166, 2005 | 44 | 2005 |
James SametPrincipal Investigator, National Health and Environmental Effects Research LaboratoryAdresse e-mail validée de email.unc.edu