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Bernhard Fasching
Bernhard Fasching
Monte Rosa Therapeutics
Adresse e-mail validée de monterosatx.com
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Toward fully synthetic homogeneous β-human follicle-stimulating hormone (β-hFSH) with a biantennary N-linked dodecasaccharide. Synthesis of β-hFSH with chitobiose units at the …
P Nagorny, B Fasching, X Li, G Chen, B Aussedat, SJ Danishefsky
Journal of the American Chemical Society 131 (16), 5792-5799, 2009
1042009
Toward the total synthesis of spirastrellolide A. Part 2: Conquest of the northern hemisphere
A Fürstner, MDB Fenster, B Fasching, C Godbout, K Radkowski
Angewandte Chemie International Edition 45 (33), 5510-5515, 2006
922006
Toward the total synthesis of spirastrellolide A. Part 1: Strategic considerations and preparation of the southern domain
A Fürstner, MDB Fenster, B Fasching, C Godbout, K Radkowski
Angewandte Chemie International Edition 45 (33), 5506-5510, 2006
842006
Safety screening in early drug discovery: an optimized assay panel
S Bendels, C Bissantz, B Fasching, G Gerebtzoff, W Guba, M Kansy, ...
Journal of pharmacological and toxicological methods 99, 106609, 2019
732019
Total synthesis of the α-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone
B Aussedat, B Fasching, E Johnston, N Sane, P Nagorny, SJ Danishefsky
Journal of the American Chemical Society 134 (7), 3532-3541, 2012
602012
Total synthesis of spirastrellolide F methyl ester—part 2: macrocyclization and completion of the synthesis
S Benson, MP Collin, GW O'Neil, J Ceccon, B Fasching, MDB Fenster, ...
Angewandte Chemie International Edition 48 (52), 9946-9950, 2009
572009
Probing the frontiers of glycoprotein synthesis: the fully elaborated β-subunit of the human follicle-stimulating hormone
P Nagorny, N Sane, B Fasching, B Aussedat, SJ Danishefsky
Angewandte Chemie (International ed. in English) 51 (4), 975, 2011
502011
Total synthesis of spirastrellolide F methyl ester—part 1: strategic considerations and revised approach to the southern hemisphere
GW O'Neil, J Ceccon, S Benson, MP Collin, B Fasching, A Fürstner
Angewandte Chemie International Edition 48 (52), 9940-9945, 2009
492009
From thalidomide to rational molecular glue design for targeted protein degradation
V Oleinikovas, P Gainza, T Ryckmans, B Fasching, NH Thomä
Annual Review of Pharmacology and Toxicology 64 (1), 291-312, 2024
472024
Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue
A Fürstner, B Fasching, GW O'Neil, MDB Fenster, C Godbout, J Ceccon
Chemical communications, 3045-3047, 2007
312007
Aggregated compound biological signatures facilitate phenotypic drug discovery and target elucidation
A Cortes Cabrera, D Lucena-Agell, M Redondo-Horcajo, I Barasoain, ...
ACS Chemical Biology 11 (11), 3024-3034, 2016
222016
Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational …
G Gavory, M Ghandi, AC d’Alessandro, D Bonenfant, A Chicas, F Delobel, ...
Cancer Research 82 (12_Supplement), 3929-3929, 2022
152022
Anti-bacterial peptide macrocycles and use thereof
A Alanine, K Amrein, K Bleicher, B Fasching, H Hilpert, S Kolczewski, ...
US Patent 11,066,443, 2021
62021
Peptide macrocycles against acinetobacter baumannii
A Alanine, J Beignet, K Bleicher, B Fasching, H Hilpert, T Hu, ...
US Patent 10,030,047, 2018
62018
Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction
G Gavory, M Ghandi, AC d’Alessandro, D Bonenfant, M Cabanski, ...
Cancer Research 83 (7_Supplement), 3449-3449, 2023
52023
Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition
G Petzold, P Gainza, S Annunziato, I Lamberto, P Trenh, LA McAllister, ...
bioRxiv, 2024.10. 07.616933, 2024
42024
Compounds that mediate protein degradation and methods of use thereof
B Fasching, T Ryckmans, A Ritzén, V Oleinikovas
US Patent App. 18/640,987, 2024
32024
Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer
G Gavory, B Fasching, D Bonenfant, A Sadok, A Singh, M Schillo, ...
Molecular Cancer Therapeutics 20 (12_Supplement), LBA004-LBA004, 2021
32021
Peptide macrocycles against Acinetobacter baumannii
A Alanine, J Beignet, K Bleicher, B Fasching, H Hilpert, T Hu, ...
US Patent 11,098,080, 2021
32021
Compound biological signatures facilitate phenotypic screening and target elucidation
AC Cabrera, D Lucena-Agell, M Redondo-Horcajo, I Barasoain, F Diaz, ...
bioRxiv, 041947, 2016
22016
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