Toward fully synthetic homogeneous β-human follicle-stimulating hormone (β-hFSH) with a biantennary N-linked dodecasaccharide. Synthesis of β-hFSH with chitobiose units at the … P Nagorny, B Fasching, X Li, G Chen, B Aussedat, SJ Danishefsky Journal of the American Chemical Society 131 (16), 5792-5799, 2009 | 104 | 2009 |
Toward the total synthesis of spirastrellolide A. Part 2: Conquest of the northern hemisphere A Fürstner, MDB Fenster, B Fasching, C Godbout, K Radkowski Angewandte Chemie International Edition 45 (33), 5510-5515, 2006 | 92 | 2006 |
Toward the total synthesis of spirastrellolide A. Part 1: Strategic considerations and preparation of the southern domain A Fürstner, MDB Fenster, B Fasching, C Godbout, K Radkowski Angewandte Chemie International Edition 45 (33), 5506-5510, 2006 | 84 | 2006 |
Safety screening in early drug discovery: an optimized assay panel S Bendels, C Bissantz, B Fasching, G Gerebtzoff, W Guba, M Kansy, ... Journal of pharmacological and toxicological methods 99, 106609, 2019 | 73 | 2019 |
Total synthesis of the α-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone B Aussedat, B Fasching, E Johnston, N Sane, P Nagorny, SJ Danishefsky Journal of the American Chemical Society 134 (7), 3532-3541, 2012 | 60 | 2012 |
Total synthesis of spirastrellolide F methyl ester—part 2: macrocyclization and completion of the synthesis S Benson, MP Collin, GW O'Neil, J Ceccon, B Fasching, MDB Fenster, ... Angewandte Chemie International Edition 48 (52), 9946-9950, 2009 | 57 | 2009 |
Probing the frontiers of glycoprotein synthesis: the fully elaborated β-subunit of the human follicle-stimulating hormone P Nagorny, N Sane, B Fasching, B Aussedat, SJ Danishefsky Angewandte Chemie (International ed. in English) 51 (4), 975, 2011 | 50 | 2011 |
Total synthesis of spirastrellolide F methyl ester—part 1: strategic considerations and revised approach to the southern hemisphere GW O'Neil, J Ceccon, S Benson, MP Collin, B Fasching, A Fürstner Angewandte Chemie International Edition 48 (52), 9940-9945, 2009 | 49 | 2009 |
From thalidomide to rational molecular glue design for targeted protein degradation V Oleinikovas, P Gainza, T Ryckmans, B Fasching, NH Thomä Annual Review of Pharmacology and Toxicology 64 (1), 291-312, 2024 | 47 | 2024 |
Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue A Fürstner, B Fasching, GW O'Neil, MDB Fenster, C Godbout, J Ceccon Chemical communications, 3045-3047, 2007 | 31 | 2007 |
Aggregated compound biological signatures facilitate phenotypic drug discovery and target elucidation A Cortes Cabrera, D Lucena-Agell, M Redondo-Horcajo, I Barasoain, ... ACS Chemical Biology 11 (11), 3024-3034, 2016 | 22 | 2016 |
Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational … G Gavory, M Ghandi, AC d’Alessandro, D Bonenfant, A Chicas, F Delobel, ... Cancer Research 82 (12_Supplement), 3929-3929, 2022 | 15 | 2022 |
Anti-bacterial peptide macrocycles and use thereof A Alanine, K Amrein, K Bleicher, B Fasching, H Hilpert, S Kolczewski, ... US Patent 11,066,443, 2021 | 6 | 2021 |
Peptide macrocycles against acinetobacter baumannii A Alanine, J Beignet, K Bleicher, B Fasching, H Hilpert, T Hu, ... US Patent 10,030,047, 2018 | 6 | 2018 |
Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction G Gavory, M Ghandi, AC d’Alessandro, D Bonenfant, M Cabanski, ... Cancer Research 83 (7_Supplement), 3449-3449, 2023 | 5 | 2023 |
Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition G Petzold, P Gainza, S Annunziato, I Lamberto, P Trenh, LA McAllister, ... bioRxiv, 2024.10. 07.616933, 2024 | 4 | 2024 |
Compounds that mediate protein degradation and methods of use thereof B Fasching, T Ryckmans, A Ritzén, V Oleinikovas US Patent App. 18/640,987, 2024 | 3 | 2024 |
Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer G Gavory, B Fasching, D Bonenfant, A Sadok, A Singh, M Schillo, ... Molecular Cancer Therapeutics 20 (12_Supplement), LBA004-LBA004, 2021 | 3 | 2021 |
Peptide macrocycles against Acinetobacter baumannii A Alanine, J Beignet, K Bleicher, B Fasching, H Hilpert, T Hu, ... US Patent 11,098,080, 2021 | 3 | 2021 |
Compound biological signatures facilitate phenotypic screening and target elucidation AC Cabrera, D Lucena-Agell, M Redondo-Horcajo, I Barasoain, F Diaz, ... bioRxiv, 041947, 2016 | 2 | 2016 |