| Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis J Bertin, RC Armstrong, S Ottilie, DA Martin, Y Wang, S Banks, GH Wang, ... Proceedings of the National Academy of Sciences 94 (4), 1172-1176, 1997 | 607 | 1997 |
| FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis SM Srinivasula, M Ahmad, S Ottilie, F Bullrich, S Banks, Y Wang, ... Journal of Biological Chemistry 272 (30), 18542-18545, 1997 | 453 | 1997 |
| Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics AN Cowell, ES Istvan, AK Lukens, MG Gomez-Lorenzo, M Vanaerschot, ... Science 359 (6372), 191-199, 2018 | 252 | 2018 |
| Dimerization properties of human Bad: Identification of a BH-3 domain and analysis of its binding to mutant Bcl-2 and Bcl-Xl proteins S Ottilie, JL Diaz, W Horne, J Chang, Y Wang, G Wilson, S Chang, ... Journal of Biological Chemistry 272 (49), 30866-30872, 1997 | 233 | 1997 |
| Bax-and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. JM Jürgensmeier, S Krajewski, RC Armstrong, GM Wilson, T Oltersdorf, ... Molecular biology of the cell 8 (2), 325-339, 1997 | 225 | 1997 |
| Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. S Ottilie, PJ Miller, DI Johnson, CL Creasy, MA Sells, S Bagrodia, ... The EMBO journal 14 (23), 5908-5919, 1995 | 196 | 1995 |
| Open-source discovery of chemical leads for next-generation chemoprotective antimalarials Y Antonova-Koch, S Meister, M Abraham, MR Luth, S Ottilie, AK Lukens, ... Science 362 (6419), eaat9446, 2018 | 121 | 2018 |
| Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity GM LaMonte, J Almaliti, B Bibo-Verdugo, L Keller, BY Zou, J Yang, ... Journal of medicinal chemistry 60 (15), 6721-6732, 2017 | 101 | 2017 |
| Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ... Nature communications 12 (1), 269, 2021 | 87 | 2021 |
| MalDA, accelerating malaria drug discovery T Yang, S Ottilie, ES Istvan, KP Godinez-Macias, AK Lukens, B Baragaña, ... Trends in parasitology 37 (6), 493-507, 2021 | 85 | 2021 |
| Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery MR Luth, P Gupta, S Ottilie, EA Winzeler ACS infectious diseases 4 (3), 301-314, 2018 | 81 | 2018 |
| Combining stage specificity and metabolomic profiling to advance antimalarial drug discovery JM Murithi, ES Owen, ES Istvan, MCS Lee, S Ottilie, K Chibale, ... Cell chemical biology 27 (2), 158-171. e3, 2020 | 80 | 2020 |
| Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity M Vanaerschot, JM Murithi, CFA Pasaje, S Ghidelli-Disse, L Dwomoh, ... Cell chemical biology 27 (7), 806-816. e8, 2020 | 76 | 2020 |
| Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome SC Xie, DL Gillett, NJ Spillman, C Tsu, MR Luth, S Ottilie, S Duffy, ... Journal of medicinal chemistry 61 (22), 10053-10066, 2018 | 70 | 2018 |
| Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris S Ottilie, F Raulf, A Barnekow, G Hannig, M Schartl | 67 | 1992 |
| Prioritization of molecular targets for antimalarial drug discovery B Forte, S Ottilie, A Plater, B Campo, KJ Dechering, FJ Gamo, ... ACS infectious diseases 7 (10), 2764-2776, 2021 | 66 | 2021 |
| Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast MA Sells, JT Barratt, J Caviston, S Ottilie, E Leberer, J Chernoff Journal of Biological Chemistry 273 (29), 18490-18498, 1998 | 66 | 1998 |
| The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis S Ottilie, J Chernoff, G Hannig, CS Hoffman, RL Erikson Molecular and cellular biology, 1992 | 66 | 1992 |
| A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. S Ottilie, J Chernoff, G Hannig, CS Hoffman, RL Erikson Proceedings of the National Academy of Sciences 88 (8), 3455-3459, 1991 | 64 | 1991 |
| Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention RL Summers, CFA Pasaje, JP Pisco, J Striepen, MR Luth, K Kumpornsin, ... Cell chemical biology 29 (2), 191-201. e8, 2022 | 62 | 2022 |
Elizabeth A. WinzelerProfessor, University of California San DiegoAdresse e-mail validée de ucsd.edu
