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Leonard Schärfen
Leonard Schärfen
PhD Student, Yale University
Adresse e-mail validée de yale.edu
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Transcription regulation through nascent RNA folding
L Schärfen, KM Neugebauer
Journal of molecular biology 433 (14), 166975, 2021
492021
Enhancing the stability of DNA origami nanostructures: staple strand redesign versus enzymatic ligation
S Ramakrishnan, L Schärfen, K Hunold, S Fricke, G Grundmeier, ...
Nanoscale 11 (35), 16270-16276, 2019
482019
Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA
AS Draycott, C Schaening-Burgos, MF Rojas-Duran, L Wilson, L Schärfen, ...
PLoS Biology 20 (5), e3001622, 2022
392022
Co-transcriptional gene regulation in eukaryotes and prokaryotes
M Shine, J Gordon, L Schärfen, D Zigackova, L Herzel, KM Neugebauer
Nature Reviews Molecular Cell Biology, 1-21, 2024
252024
Real-time monitoring of protein-induced DNA conformational changes using single-molecule FRET
L Schärfen, M Schlierf
Methods 169, 11-20, 2019
142019
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data
S Bryce-Smith, D Burri, MR Gazzara, CJ Herrmann, W Danecka, ...
RNA 29 (12), 1839-1855, 2023
132023
Identification of Alternative Polyadenylation in Cyanidioschyzon merolae Through Long-Read Sequencing of mRNA
L Schärfen, D Zigackova, KA Reimer, MR Stark, VA Slat, NJ Francoeur, ...
Frontiers in Genetics 12, 818697, 2022
52022
Fast, simultaneous tagging and mutagenesis of genes on bacterial chromosomes
L Scharfen, M Tisma, M Schlierf
ACS Synthetic Biology 9 (8), 2203-2207, 2020
22020
Direct visualization of four diffusive LexA states controlling SOS response strength during antibiotic treatment
L Schärfen, M Tišma, A Hartmann, M Schlierf
bioRxiv, 2020.07. 14.201889, 2020
12020
Identification of coilin interactors reveals coordinated control of Cajal body number and structure
D Arias Escayola, C Zhang, E Nischwitz, L Schärfen, K Dörner, K Straube, ...
Journal of Cell Biology 224 (2), 2025
2025
Phosphorylation of the nuclear poly (A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics
JM Gordon, DV Phizicky, L Schärfen, CL Brown, D Arias Escayola, ...
Nucleic Acids Research 52 (16), 9886-9903, 2024
2024
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
L Schärfen, IW Vock, MD Simon, KM Neugebauer
bioRxiv, 2024.11. 26.625435, 2024
2024
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