| Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets L Cassetta, S Fragkogianni, AH Sims, A Swierczak, LM Forrester, ... Cancer cell 35 (4), 588-602. e10, 2019 | 822 | 2019 |
| MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures T Mondal, S Subhash, R Vaid, S Enroth, S Uday, B Reinius, S Mitra, ... Nature communications 6 (1), 7743, 2015 | 671 | 2015 |
| Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity A Serrels, T Lund, B Serrels, A Byron, RC McPherson, A von Kriegsheim, ... Cell 163 (1), 160-173, 2015 | 406 | 2015 |
| Origins of breast cancer subtypes and therapeutic implications AH Sims, A Howell, SJ Howell, RB Clarke Nature Clinical Practice Oncology 4 (9), 516-525, 2007 | 288 | 2007 |
| MCL-1 is a prognostic indicator and drug target in breast cancer KJ Campbell, S Dhayade, N Ferrari, AH Sims, E Johnson, SM Mason, ... Cell death & disease 9 (2), 19, 2018 | 202 | 2018 |
| Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ... Cell reports 12 (12), 1968-1977, 2015 | 202 | 2015 |
| The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets–improving meta-analysis and prediction of prognosis AH Sims, GJ Smethurst, Y Hey, MJ Okoniewski, SD Pepper, A Howell, ... BMC medical genomics 1, 1-14, 2008 | 194 | 2008 |
| Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns D Sproul, RR Kitchen, CE Nestor, JM Dixon, AH Sims, DJ Harrison, ... Genome biology 13, 1-16, 2012 | 193 | 2012 |
| Immune cell gene signatures for profiling the microenvironment of solid tumors AJ Nirmal, T Regan, BB Shih, DA Hume, AH Sims, TC Freeman Cancer immunology research 6 (11), 1388-1400, 2018 | 192 | 2018 |
| Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer D Sproul, C Nestor, J Culley, JH Dickson, JM Dixon, DJ Harrison, ... Proceedings of the National Academy of Sciences 108 (11), 4364-4369, 2011 | 182 | 2011 |
| Wnt pathway activity in breast cancer sub-types and stem-like cells R Lamb, MP Ablett, K Spence, G Landberg, AH Sims, RB Clarke PloS one 8 (7), e67811, 2013 | 173 | 2013 |
| KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals S Moleirinho, N Chang, AH Sims, AM Tilston-Lünel, L Angus, A Steele, ... Oncogene 32 (14), 1821-1830, 2013 | 144 | 2013 |
| Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling R Eyre, DG Alférez, A Santiago-Gómez, K Spence, JC McConnell, C Hart, ... Nature communications 10 (1), 5016, 2019 | 138 | 2019 |
| Cyclin D1, Id1 and EMT in breast cancer NP Tobin, AH Sims, KL Lundgren, S Lehn, G Landberg BMC cancer 11, 1-14, 2011 | 137 | 2011 |
| Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth RY Ma, H Zhang, XF Li, CB Zhang, C Selli, G Tagliavini, AD Lam, S Prost, ... Journal of Experimental Medicine 217 (11), e20191820, 2020 | 132 | 2020 |
| Accurate prediction and validation of response to endocrine therapy in breast cancer AK Turnbull, LM Arthur, L Renshaw, AA Larionov, C Kay, AK Dunbier, ... Journal of Clinical Oncology 33 (20), 2270-2278, 2015 | 132 | 2015 |
| The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers ME Rieger, AH Sims, ER Coats, RB Clarke, KJ Briegel Molecular and cellular biology, 2010 | 111 | 2010 |
| Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue CL Wilson, AH Sims, A Howell, CJ Miller, RB Clarke Endocrine-related cancer 13 (2), 617-628, 2006 | 111 | 2006 |
| Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers C Selli, JM Dixon, AH Sims Breast Cancer Research 18, 1-10, 2016 | 109 | 2016 |
| Transcriptome Analysis of Recombinant Protein Secretion by Aspergillus nidulans and the Unfolded-Protein Response In Vivo AH Sims, ME Gent, K Lanthaler, NS Dunn-Coleman, SG Oliver, ... Applied and environmental microbiology 71 (5), 2737-2747, 2005 | 106 | 2005 |
Robert B ClarkeProfessor of Breast Biology, University of ManchesterAdresse e-mail validée de manchester.ac.uk