David Ascher

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Douglas PiresChief Data Officer, XymeAdresse e-mail validée de xyme.ai
Tom L BlundellEmeritus Professor of Biochemistry, University of CambridgeAdresse e-mail validée de cam.ac.uk
Carlos RodriguesCSIRO - Australian Centre for Disease PreparednessAdresse e-mail validée de csiro.au
Michael W. ParkerSt Vincent's Institute of Medical Research and The University of MelbourneAdresse e-mail validée de svi.edu.au
Craig MortonPrincipal Research Scientist, CSIROAdresse e-mail validée de CSIRO.au
Harry JubbCresset Biomolecular Discovery LtdAdresse e-mail validée de cresset-group.com
Justin DenholmVictorian Tuberculosis ProgramAdresse e-mail validée de mh.org.au
Kathryn HoltLSHTM & Monash UniversityAdresse e-mail validée de lshtm.ac.uk
Arun Prasad PanduranganDepartment of Medicine, University of CambridgeAdresse e-mail validée de cam.ac.uk
Joicymara S. XavierITA - Instituto Tecnológico de AeronáuticaAdresse e-mail validée de ita.br
Tracy NeroAdresse e-mail validée de unimelb.edu.au
Dimitri Y. ChirgadzeUniversity of CambridgeAdresse e-mail validée de cam.ac.uk
Taane G. ClarkProfessor of Genomics & Global Health, London School of Hygiene and Tropical MedicineAdresse e-mail validée de lshtm.ac.uk
Chris PorterDirector, Monash Institute of Pharmaceutical Sciences, Monash UniversityAdresse e-mail validée de monash.edu
Spencer J WilliamsSchool of Chemistry and Bio21 Institute, University of MelbourneAdresse e-mail validée de unimelb.edu.au
Jody PhelanLSHTMAdresse e-mail validée de lshtm.ac.uk
Valerie MizrahiUniversity of Cape TownAdresse e-mail validée de uct.ac.za
Pâmela Marinho RezendeDoutoranda em Bioinformática, Universidade Federal de Minas GeraisAdresse e-mail validée de minas.fiocruz.br
Hugh HarrisThe University of AdelaideAdresse e-mail validée de adelaide.edu.au
Emma R. WoodwardManchester Centre for Genomic MedicineAdresse e-mail validée de mft.nhs.uk

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David Ascher

University of Queensland; Baker Institute

Adresse e-mail validée de uq.edu.au - Page d'accueil

Structural Bioinformatics Computational Biology Medical Informatics Artificial intelligence Drug


Titre Trier par citations Trier par année Trier par titre	Citée par Citée par	Année
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures DEV Pires, TL Blundell, DB Ascher Journal of medicinal chemistry 58 (9), 4066-4072, 2015	4162	2015
mCSM: predicting the effects of mutations in proteins using graph-based signatures DEV Pires, DB Ascher, TL Blundell Bioinformatics 30 (3), 335-342, 2014	1020	2014
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability CHM Rodrigues, DEV Pires, DB Ascher Nucleic acids research 46 (W1), W350-W355, 2018	970	2018
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach DEV Pires, DB Ascher, TL Blundell Nucleic acids research 42 (W1), W314-W319, 2014	881	2014
A structural biology community assessment of AlphaFold2 applications M Akdel, DEV Pires, EP Pardo, J Jänes, AO Zalevsky, B Mészáros, ... Nature Structural & Molecular Biology 29 (11), 1056-1067, 2022	496	2022
SDM: a server for predicting effects of mutations on protein stability AP Pandurangan, B Ochoa-Montano, DB Ascher, TL Blundell Nucleic acids research 45 (W1), W229-W235, 2017	491	2017
Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures HC Jubb, AP Higueruelo, B Ochoa-Montaño, WR Pitt, DB Ascher, ... Journal of molecular biology 429 (3), 365-371, 2017	432	2017
DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations CHM Rodrigues, DEV Pires, DB Ascher Protein Science 30 (1), 60-69, 2021	397	2021
mCSM-PPI2: predicting the effects of mutations on protein–protein interactions CHM Rodrigues, Y Myung, DEV Pires, DB Ascher Nucleic acids research 47 (W1), W338-W344, 2019	326	2019
Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD KA Andrews, DB Ascher, DEV Pires, DR Barnes, L Vialard, RT Casey, ... Journal of medical genetics 55 (6), 384-394, 2018	240	2018
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha, NN Lan, NH Lan, ... Nature genetics 50 (6), 849-856, 2018	198	2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation J Traynelis, M Silk, Q Wang, SF Berkovic, L Liu, DB Ascher, DJ Balding, ... Genome research 27 (10), 1715-1729, 2017	198	2017
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair BL Sibanda, DY Chirgadze, DB Ascher, TL Blundell Science 355 (6324), 520-524, 2017	184	2017
Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health HC Jubb, AP Pandurangan, MA Turner, B Ochoa-Montaño, TL Blundell, ... Progress in biophysics and molecular biology 128, 3-13, 2017	177	2017
Deep learning in diabetic foot ulcers detection: a comprehensive evaluation MH Yap, R Hachiuma, A Alavi, R Brüngel, B Cassidy, M Goyal, H Zhu, ... Computers in biology and medicine 135, 104596, 2021	159	2021
Flexibility and small pockets at protein–protein interfaces: new insights into druggability H Jubb, TL Blundell, DB Ascher Progress in biophysics and molecular biology 119 (1), 2-9, 2015	154	2015
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker Scientific reports 4 (1), 4765, 2014	143	2014
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance DEV Pires, TL Blundell, DB Ascher Scientific reports 6 (1), 29575, 2016	138	2016
mCSM-AB: a web server for predicting antibody–antigen affinity changes upon mutation with graph-based signatures DEV Pires, DB Ascher Nucleic acids research 44 (W1), W469-W473, 2016	129	2016
Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase AL Albiston, CJ Morton, HL Ng, V Pham, HR Yeatman, S Ye, ... The FASEB Journal 22 (12), 4209-4217, 2008	129	2008

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