| Integrin activation controls metastasis in human breast cancer B Felding-Habermann, TE O'Toole, JW Smith, E Fransvea, ZM Ruggeri, ... Proceedings of the National Academy of Sciences 98 (4), 1853-1858, 2001 | 779 | 2001 |
| Breaking the Integrin Hinge: A DEFINED STRUCTURAL CONSTRAINT REGULATES INTEGRIN SIGNALING (∗) PE Hughes, F Diaz-Gonzalez, L Leong, C Wu, JA McDonald, SJ Shattil, ... Journal of Biological Chemistry 271 (12), 6571-6574, 1996 | 762 | 1996 |
| Integrin affinity modulation PE Hughes, M Pfaff Trends in cell biology 8 (9), 359-364, 1998 | 614 | 1998 |
| Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway PE Hughes, MW Renshaw, M Pfaff, J Forsyth, VM Keivens, MA Schwartz, ... Cell 88 (4), 521-530, 1997 | 609 | 1997 |
| AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies S Caenepeel, SP Brown, B Belmontes, G Moody, KS Keegan, D Chui, ... Cancer discovery 8 (12), 1582-1597, 2018 | 414 | 2018 |
| Complementation of dominant suppression implicates CD98 in integrin activation CA Fenczik, T Sethi, JW Ramos, PE Hughes, MH Ginsberg Nature 390 (6655), 81-85, 1997 | 356 | 1997 |
| Targeted therapy and checkpoint immunotherapy combinations for the treatment of cancer PE Hughes, S Caenepeel, LC Wu Trends in immunology 37 (7), 462-476, 2016 | 300 | 2016 |
| The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity (∗) PE Hughes, TE O'Toole, J Ylänne, SJ Shattil, MH Ginsberg Journal of Biological Chemistry 270 (21), 12411-12417, 1995 | 252 | 1995 |
| The inner world of cell adhesion: integrin cytoplasmic domains MJ Williams, PE Hughes, TE O'Toole, MH Ginsberg Trends in cell biology 4 (4), 109-112, 1994 | 245 | 1994 |
| Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets DA Law, L Nannizzi-Alaimo, K Ministri, PE Hughes, J Forsyth, M Turner, ... Blood, The Journal of the American Society of Hematology 93 (8), 2645-2652, 1999 | 223 | 1999 |
| Targeting MCL-1 in hematologic malignancies: Rationale and progress AH Wei, AW Roberts, A Spencer, AS Rosenberg, D Siegel, RB Walter, ... Blood reviews 44, 100672, 2020 | 187 | 2020 |
| AMG 757, a half-life extended, DLL3-targeted bispecific T-cell engager, shows high potency and sensitivity in preclinical models of small-cell lung cancer MJ Giffin, K Cooke, EK Lobenhofer, J Estrada, J Zhan, P Deegen, ... Clinical Cancer Research 27 (5), 1526-1537, 2021 | 186 | 2021 |
| Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2–neutralizing peptibody A Coxon, J Bready, H Min, S Kaufman, J Leal, D Yu, TA Lee, JR Sun, ... Molecular cancer therapeutics 9 (10), 2641-2651, 2010 | 175 | 2010 |
| Identification of a New Biological Function for the Integrin αvβ3: Initiation of Fibronectin Matrix Assembly C Wu, PE Hughes, MH Ginsberg, JA McDonald Cell adhesion and communication 4 (3), 149-158, 1996 | 148 | 1996 |
| Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors ND D’Angelo, TS Kim, K Andrews, SK Booker, S Caenepeel, K Chen, ... Journal of medicinal chemistry 54 (6), 1789-1811, 2011 | 130 | 2011 |
| Evolution of a highly selective and potent 2-(pyridin-2-yl)-1, 3, 5-triazine Tie-2 kinase inhibitor BL Hodous, SD Geuns-Meyer, PE Hughes, BK Albrecht, S Bellon, ... Journal of medicinal chemistry 50 (4), 611-626, 2007 | 121 | 2007 |
| The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway T Sethi, MH Ginsberg, J Downward, PE Hughes Molecular Biology of the Cell 10 (6), 1799-1809, 1999 | 118 | 1999 |
| The death effector domain of PEA-15 is involved in its regulation of integrin activation JW Ramos, TK Kojima, PE Hughes, CA Fenczik, MH Ginsberg Journal of Biological Chemistry 273 (51), 33897-33900, 1998 | 103 | 1998 |
| Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell … V Nangia, FM Siddiqui, S Caenepeel, D Timonina, SJ Bilton, N Phan, ... Cancer discovery 8 (12), 1598-1613, 2018 | 97 | 2018 |
| Integrin signaling: roles for the cytoplasmic tails of αIIbβ3 in the tyrosine phosphorylation of pp125FAK L Leong, PE Hughes, MA Schwartz, MH Ginsberg, SJ Shattil Journal of Cell Science 108 (12), 3817-3825, 1995 | 89 | 1995 |
Mark H GinsbergUniversity of California San DiegoAdresse e-mail validée de ucsd.edu