| An environment-dependent transcriptional network specifies human microglia identity D Gosselin, D Skola, NG Coufal, IR Holtman, JCM Schlachetzki, E Sajti, ... Science 356 (6344), eaal3222, 2017 | 1143 | 2017 |
| Transcriptomic analysis of purified human cortical microglia reveals age-associated changes TF Galatro, IR Holtman, AM Lerario, ID Vainchtein, N Brouwer, PR Sola, ... Nature neuroscience 20 (8), 1162-1171, 2017 | 732 | 2017 |
| Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis IR Holtman, DD Raj, JA Miller, W Schaafsma, Z Yin, N Brouwer, PD Wes, ... Acta neuropathologica communications 3, 1-18, 2015 | 629 | 2015 |
| Brain cell type–specific enhancer–promoter interactome maps and disease-risk association A Nott, IR Holtman, NG Coufal, JCM Schlachetzki, M Yu, R Hu, CZ Han, ... Science 366 (6469), 1134-1139, 2019 | 622 | 2019 |
| A novel microglial subset plays a key role in myelinogenesis in developing brain A Wlodarczyk, IR Holtman, M Krueger, N Yogev, J Bruttger, R Khorooshi, ... The EMBO journal 36 (22), 3292-3308, 2017 | 484 | 2017 |
| Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1 F Szulzewsky, A Pelz, X Feng, M Synowitz, D Markovic, T Langmann, ... PloS one 10 (2), e0116644, 2015 | 432 | 2015 |
| Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease Z Yin, D Raj, N Saiepour, D Van Dam, N Brouwer, IR Holtman, BJL Eggen, ... Neurobiology of aging 55, 115-122, 2017 | 255 | 2017 |
| Transcriptional control of microglia phenotypes in health and disease IR Holtman, D Skola, CK Glass The Journal of clinical investigation 127 (9), 3220-3229, 2017 | 203 | 2017 |
| Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function VM Link, SH Duttke, HB Chun, IR Holtman, E Westin, MA Hoeksema, ... Cell 173 (7), 1796-1809. e17, 2018 | 193 | 2018 |
| Increased white matter inflammation in aging-and Alzheimer’s disease brain D Raj, Z Yin, M Breur, J Doorduin, IR Holtman, M Olah, IJ Mantingh-Otter, ... Frontiers in molecular neuroscience 10, 206, 2017 | 176 | 2017 |
| Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease PD Wes, IR Holtman, EWGM Boddeke, T Möller, BJL Eggen Glia 64 (2), 197-213, 2016 | 163 | 2016 |
| Priming of microglia in a DNA-repair deficient model of accelerated aging DDA Raj, D Jaarsma, IR Holtman, M Olah, FM Ferreira, W Schaafsma, ... Neurobiology of aging 35 (9), 2147-2160, 2014 | 159 | 2014 |
| Diet-regulated production of PDGFcc by macrophages controls energy storage N Cox, L Crozet, IR Holtman, PL Loyher, T Lazarov, JB White, E Mass, ... Science 373 (6550), eabe9383, 2021 | 117 | 2021 |
| Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin M Bsibsi, LAN Peferoen, IR Holtman, PJ Nacken, WH Gerritsen, ME Witte, ... Acta neuropathologica 128, 215-229, 2014 | 111 | 2014 |
| Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish N Oosterhof, IR Holtman, LE Kuil, HC van der Linde, EWGM Boddeke, ... Glia 65 (1), 138-149, 2017 | 91 | 2017 |
| CD 14 is a key organizer of microglial responses to CNS infection and injury H Janova, C Böttcher, IR Holtman, T Regen, D van Rossum, A Götz, ... Glia 64 (4), 635-649, 2016 | 90 | 2016 |
| Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening DDA Raj, J Moser, SMA van der Pol, RP van Os, IR Holtman, N Brouwer, ... Aging cell 14 (6), 1003-1013, 2015 | 72 | 2015 |
| Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease IR Holtman, M Noback, M Bijlsma, KN Duong, MA van der Geest, ... Glia 63 (9), 1495-1506, 2015 | 64 | 2015 |
| Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA … JM van Noort, M Bsibsi, PJ Nacken, WH Gerritsen, S Amor, IR Holtman, ... Biomaterials 34 (3), 831-840, 2013 | 59 | 2013 |
| Lymphocryptovirus infection of nonhuman primate B cells converts destructive into productive processing of the pathogenic CD8 T cell epitope in myelin oligodendrocyte glycoprotein SA Jagessar, IR Holtman, S Hofman, E Morandi, N Heijmans, JD Laman, ... The Journal of Immunology 197 (4), 1074-1088, 2016 | 55 | 2016 |
glass ckProfessor Cellular and Molecular Medicine UC San DiegoAdresse e-mail validée de ucsd.edu
