Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ RT Nolte, GB Wisely, S Westin, JE Cobb, MH Lambert, R Kurokawa, ... Nature 395 (6698), 137-143, 1998 | 2486 | 1998 |
Molecular recognition of fatty acids by peroxisome proliferator–activated receptors HE Xu, MH Lambert, VG Montana, DJ Parks, SG Blanchard, PJ Brown, ... Molecular cell 3 (3), 397-403, 1999 | 1528 | 1999 |
An atlas of genetic influences on human blood metabolites SY Shin, EB Fauman, AK Petersen, J Krumsiek, R Santos, J Huang, ... Nature genetics 46 (6), 543-550, 2014 | 1461 | 2014 |
Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins MV Milburn, L Tong, AM DeVos, A Brünger, Z Yamaizumi, S Nishimura, ... Science 247 (4945), 939-945, 1990 | 1409 | 1990 |
Human metabolic individuality in biomedical and pharmaceutical research K Suhre, SY Shin, AK Petersen, RP Mohney, D Meredith, B Wägele, ... Nature 477 (7362), 54-60, 2011 | 1127 | 2011 |
Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors RT Gampe, VG Montana, MH Lambert, AB Miller, RK Bledsoe, MV Milburn, ... Molecular cell 5 (3), 545-555, 2000 | 757 | 2000 |
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation EM McInerney, DW Rose, SE Flynn, S Westin, TM Mullen, A Krones, ... Genes & development 12 (21), 3357-3368, 1998 | 755 | 1998 |
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting K Suhre, C Meisinger, A Döring, E Altmaier, P Belcredi, C Gieger, ... PloS one 5 (11), e13953, 2010 | 688 | 2010 |
Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H-ras P21 AM De Vos, L Tong, MV Milburn, PM Matias, J Jancarik, S Noguchi, ... Science 239 (4842), 888-893, 1988 | 667 | 1988 |
α-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population WE Gall, K Beebe, KA Lawton, KP Adam, MW Mitchell, PJ Nakhle, ... PloS one 5 (5), e10883, 2010 | 660 | 2010 |
Molecular determinants of nuclear receptor–corepressor interaction V Perissi, LM Staszewski, EM McInerney, R Kurokawa, A Krones, ... Genes & development 13 (24), 3198-3208, 1999 | 629 | 1999 |
Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand MV Milburn, GG Privé, DL Milligan, WG Scott, J Yeh, J Jancarik, ... Science 254 (5036), 1342-1347, 1991 | 541 | 1991 |
Analysis of the adult human plasma metabolome KA Lawton, A Berger, M Mitchell, KE Milgram, AM Evans, L Guo, ... Pharmacogenomics 9 (4), 383-397, 2008 | 534 | 2008 |
Structural basis for the activity of drugs that inhibit phosphodiesterases GL Card, BP England, Y Suzuki, D Fong, B Powell, B Lee, C Luu, ... Structure 12 (12), 2233-2247, 2004 | 483 | 2004 |
A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation JL Oberfield, JL Collins, CP Holmes, DM Goreham, JP Cooper, JE Cobb, ... Proceedings of the National Academy of Sciences 96 (11), 6102-6106, 1999 | 457 | 1999 |
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity RX Xu, AM Hassell, D Vanderwall, MH Lambert, WD Holmes, MA Luther, ... Science 288 (5472), 1822-1825, 2000 | 446 | 2000 |
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators S Westin, R Kurokawa, RT Nolte, GB Wisely, EM McInerney, DW Rose, ... Nature 395 (6698), 199-202, 1998 | 436 | 1998 |
Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance E Ferrannini, A Natali, S Camastra, M Nannipieri, A Mari, KP Adam, ... Diabetes 62 (5), 1730-1737, 2013 | 388 | 2013 |
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases KYJ Zhang, GL Card, Y Suzuki, DR Artis, D Fong, S Gillette, D Hsieh, ... Molecular cell 15 (2), 279-286, 2004 | 377 | 2004 |
A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5 MV Milburn, AM Hassell, MH Lambert, SR Jordan, AEI Proudfoot, ... Nature 363 (6425), 172-176, 1993 | 368 | 1993 |