Joanne (Hulett) Hildebrand

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John SilkeProfessor, The Walter and Eliza Hall InstituteAdresse e-mail validée de latrobe.edu.au
Andrew I. WebbAssociate Professor - The Walter and Eliza Hall InstituteAdresse e-mail validée de wehi.edu.au
jeff babonwalter and eliza hall instituteAdresse e-mail validée de wehi.edu.au
Najoua LalaouiGroup Leader, Peter MacCallum Cancer CenterAdresse e-mail validée de petermac.org
Jian-Guo ZhangSenior Research Scientist, The Walter and Eliza Hall Institute of Medical Research, MelbourneAdresse e-mail validée de wehi.edu.au
Renwick CJ DobsonProfessor of Chemical Biology, School of Biological Sciences, University of CanterburyAdresse e-mail validée de canterbury.ac.nz
Paul GooleyUniversity of MelbourneAdresse e-mail validée de unimelb.edu.au
Silvia Alvarez-DiazPostdoctoral Fellow at Walter and Eliza Hall Institute of Medical ResearchAdresse e-mail validée de wehi.edu.au
Andreas StrasserThe Walter and Eliza Hall InstituteAdresse e-mail validée de wehi.edu.au
Nicos A NicolaDivision Head, Walter and Eliza Hall InstituteAdresse e-mail validée de wehi.edu.au
Andrew J. PerryMonash UniversityAdresse e-mail validée de monash.edu
Vladimir LikicAdresse e-mail validée de spin.net.au
Martin ScanlonProfessor of Medicinal Chemistry, Monash UniversityAdresse e-mail validée de monash.edu
Wei-Hao LinCarnegie Mellon UniversityAdresse e-mail validée de cs.cmu.edu
Zhenghua LuoThe Ohio State UniversityAdresse e-mail validée de osumc.edu
Ryan ListerUniversity of Western Australia; Harry Perkins Institute of Medical ResearchAdresse e-mail validée de uwa.edu.au
Nicolas (Nic) TaylorAssociate Professor, The University of Western AustraliaAdresse e-mail validée de uwa.edu.au
A. Harvey MillarARC Laureate Fellow | ARC Centre of Excellence in Plant Energy Biology, The University of WesternAdresse e-mail validée de uwa.edu.au
Ross F WallerUniversity of CambridgeAdresse e-mail validée de cam.ac.uk
Dr Pooja SharmaHarvard Medical School, Amgen, Monash University, WEHI-Melbourne University

Suivre

Joanne (Hulett) Hildebrand

Medical Science Liaison, Eli Lilly ANZ. Former Senior Research Scientist, WEHI

Aucune adresse e-mail validée - Page d'accueil

Inflammation Necroptosis Cell death MLKL


Titre Trier par citations Trier par année Trier par titre	Citée par Citée par	Année
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ... Immunity 39 (3), 443-453, 2013	1254	2013
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014	602	2014
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ... Nature communications 11 (1), 3151, 2020	281	2020
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018	195	2018
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ... Nature microbiology 2 (4), 1-10, 2017	192	2017
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ... Cell death & disease 7 (1), e2051-e2051, 2016	168	2016
Convergent evolution of receptors for protein import into mitochondria AJ Perry, JM Hulett, VA Likić, T Lithgow, PR Gooley Current Biology 16 (3), 221-229, 2006	145	2006
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production U Nachbur, CA Stafford, A Bankovacki, Y Zhan, LM Lindqvist, BK Fiil, ... Nature communications 6 (1), 6442, 2015	138	2015
A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling JM Hildebrand, Z Luo, MK Manske, T Price-Troska, SC Ziesmer, W Lin, ... Journal of Experimental Medicine 207 (12), 2569-2579, 2010	123	2010
The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex JM Hulett, F Lueder, NC Chan, AJ Perry, P Wolynec, VA Likić, PR Gooley, ... Journal of molecular biology 376 (3), 694-704, 2008	123	2008
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions JM Hildebrand, Z Yi, CM Buchta, J Poovassery, LL Stunz, GA Bishop Immunological reviews 244 (1), 55-74, 2011	121	2011
Evolutionary divergence of the necroptosis effector MLKL MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, ... Cell Death & Differentiation 23 (7), 1185-1197, 2016	120	2016
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ... Biochemical Journal 457 (3), 369-377, 2014	115	2014
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop MC Tanzer, A Tripaydonis, AI Webb, SN Young, LN Varghese, C Hall, ... Biochemical Journal 471 (2), 255-265, 2015	112	2015
Protein import into mitochondria: origins and functions today R Lister, JM Hulett, T Lithgow, J Whelan Molecular membrane biology 22 (1-2), 87-100, 2005	105	2005
Insane in the membrane: a structural perspective of MLKL function in necroptosis EJ Petrie, JM Hildebrand, JM Murphy Immunology and cell biology 95 (2), 152-159, 2017	85	2017
Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted MD Stutz, S Ojaimi, C Allison, S Preston, P Arandjelovic, JM Hildebrand, ... Cell Death & Differentiation 25 (5), 951-965, 2018	81	2018
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis SE Garnish, Y Meng, A Koide, JJ Sandow, E Denbaum, AV Jacobsen, ... Nature communications 12 (1), 2211, 2021	79	2021
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction JM Hildebrand, M Kauppi, IJ Majewski, Z Liu, AJ Cox, S Miyake, EJ Petrie, ... Nature communications 11 (1), 3150, 2020	79	2020
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs S Murai, Y Yamaguchi, Y Shirasaki, M Yamagishi, R Shindo, ... Nature communications 9 (1), 4457, 2018	76	2018

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