| Engineering extrinsic disorder to control protein activity in living cells O Dagliyan, M Tarnawski, PH Chu, D Shirvanyants, I Schlichting, ... Science 354 (6318), 1441-1444, 2016 | 234 | 2016 |
| Rational design of a ligand-controlled protein conformational switch O Dagliyan, D Shirvanyants, A Karginov, F Ding, SN Chandrasekaran, ... Proceedings of the National Academy of Sciences (PNAS) 104 (2), 18a-19a, 2013 | 132 | 2013 |
| Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network EL Yap, NL Pettit, CP Davis, MA Nagy, DA Harmin, E Golden, O Dagliyan, ... Nature 590 (7844), 115-121, 2021 | 124 | 2021 |
| Optimization based tumor classification from microarray gene expression data O Dagliyan, F Uney-Yuksektepe, IH Kavakli, M Turkay PloS one 6 (2), e14579, 2011 | 123 | 2011 |
| Structural and dynamic determinants of protein-peptide recognition O Dagliyan, EA Proctor, KM D'Auria, F Ding, NV Dokholyan Structure 19 (12), 1837-1845, 2011 | 120 | 2011 |
| Computational design of chemogenetic and optogenetic split proteins O Dagliyan, A Krokhotin, I Ozkan-Dagliyan, A Deiters, CJ Der, KM Hahn, ... Nature communications 9 (1), 4042, 2018 | 100 | 2018 |
| Low-dose vertical inhibition of the RAF-MEK-ERK cascade causes apoptotic death of KRAS mutant cancers I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, ... Cell reports 31 (11), 2020 | 90 | 2020 |
| Expression of the transcription factor PU. 1 induces the generation of microglia-like cells in human cortical organoids B Cakir, Y Tanaka, FR Kiral, Y Xiang, O Dagliyan, J Wang, M Lee, ... Nature Communications 13 (1), 430, 2022 | 88 | 2022 |
| Knowledge-based design of a biosensor to quantify localized ERK activation in living cells L Kummer, CW Hsu, O Dagliyan, C MacNevin, M Kaufholz, ... Chemistry & biology 20 (6), 847-856, 2013 | 68 | 2013 |
| Engineering proteins for allosteric control by light or ligands O Dagliyan, NV Dokholyan, KM Hahn Nature protocols 14 (6), 1863-1883, 2019 | 67 | 2019 |
| Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms PH Chu, D Tsygankov, ME Berginski, O Dagliyan, SM Gomez, TC Elston, ... Proceedings of the National Academy of Sciences 111 (34), 12420-12425, 2014 | 63 | 2014 |
| Computational approaches to understanding protein aggregation in neurodegeneration RL Redler, D Shirvanyants, O Dagliyan, F Ding, DN Kim, P Kota, ... Journal of molecular cell biology 6 (2), 104-115, 2014 | 52 | 2014 |
| FRET binding antenna reports spatiotemporal dynamics of GDI–Cdc42 GTPase interactions L Hodgson, D Spiering, M Sabouri-Ghomi, O Dagliyan, ... Nature chemical biology 12 (10), 802-809, 2016 | 51 | 2016 |
| Rational design and implementation of a chemically inducible heterotrimerization system HD Wu, M Kikuchi, O Dagliyan, AK Aragaki, H Nakamura, NV Dokholyan, ... Nature Methods 17, 928–936, 2020 | 48 | 2020 |
| Rational design and implementation of a chemically inducible hetero-trimerization system HD Wu, M Kikuchi, O Dagliyan, AK Aragaki, H Nakamura, NV Dokholyan, ... bioRxiv, 2020 | 48 | 2020 |
| Profiling cellular morphodynamics by spatiotemporal spectrum decomposition X Ma, O Dagliyan, KM Hahn, G Danuser PLoS computational biology 14 (8), e1006321, 2018 | 43 | 2018 |
| Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme B Cakir, O Dağliyan, E Dağyildiz, İ Bariş, IH Kavakli, S Kizilel, M Türkay PLoS One 7 (2), e31787, 2012 | 40 | 2012 |
| Classification of Cytochrome P450 Inhibitors with Respect to Binding Free Energy and pIC50 Using Common Molecular Descriptors O Dagliyan, IH Kavakli, M Turkay Journal of chemical information and modeling 49 (10), 2403-2411, 2009 | 33 | 2009 |
| Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity TC Freeman Jr, JL Black, HG Bray, O Dagliyan, YI Wu, A Tripathy, ... Biochemistry 52 (40), 7082-7090, 2013 | 32 | 2013 |
| Engineering Pak1 allosteric switches O Dagliyan, AV Karginov, S Yagishita, ME Gale, H Wang, ... ACS synthetic biology 6 (7), 1257-1262, 2017 | 30 | 2017 |
Klaus M HahnProfessor of Pharmacology, University of North Carolina Chapel HillAdresse e-mail validée de med.unc.edu
