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Lara Pferdehirt
Lara Pferdehirt
Adresse e-mail validée de wustl.edu
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A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues
RJ Nims, L Pferdehirt, NB Ho, A Savadipour, J Lorentz, S Sohi, J Kassab, ...
Science Advances 7 (5), eabd9858, 2021
752021
A synthetic gene circuit for self-regulating delivery of biologic drugs in engineered tissues
L Pferdehirt, AK Ross, JM Brunger, F Guilak
Tissue Engineering Part A 25 (9-10), 809-820, 2019
422019
Immunoengineering the next generation of arthritis therapies
M Klimak, RJ Nims, L Pferdehirt, KH Collins, NS Harasymowicz, ...
Acta biomaterialia 133, 74-86, 2021
412021
Quantitatively predictable control of cellular protein levels through proteasomal degradation
W Zhao, L Pferdehirt, L Segatori
ACS Synthetic Biology 7 (2), 540-552, 2018
412018
A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery
YR Choi, KH Collins, LE Springer, L Pferdehirt, AK Ross, CL Wu, ...
Science Advances 7 (36), eabj1414, 2021
372021
Designer stem cells: Genome engineering and the next generation of cell‐based therapies
F Guilak, L Pferdehirt, AK Ross, YR Choi, KH Collins, RJ Nims, DB Katz, ...
Journal of Orthopaedic Research® 37 (6), 1287-1293, 2019
362019
Mechanogenetics: harnessing mechanobiology for cellular engineering
RJ Nims, L Pferdehirt, F Guilak
Current opinion in biotechnology 73, 374-379, 2022
282022
Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation
L Pferdehirt, AR Damato, M Dudek, QJ Meng, ED Herzog, F Guilak
Science Advances 8 (21), eabj8892, 2022
172022
Hydrogel encapsulation of genome-engineered stem cells for long-term self-regulating anti-cytokine therapy
KH Collins, L Pferdehirt, LS Saleh, A Savadipour, LE Springer, KL Lenz, ...
Gels 9 (2), 169, 2023
112023
In vitro analysis of genome‐engineered muscle‐derived stem cells for autoregulated anti‐inflammatory and antifibrotic activity
L Pferdehirt, P Guo, A Lu, M Huard, F Guilak, J Huard
Journal of Orthopaedic Research® 40 (12), 2937-2946, 2022
12022
A synthetic chronogenetic gene circuit for programmed circadian drug delivery
L Pferdehirt, AR Damato, KL Lenz, MF Gonzalez-Aponte, D Palmer, ...
Nature Communications 16 (1), 1457, 2025
2025
Compositions and methods for cell-based delivery systems
F Guilak, L Pferdehirt
US Patent App. 18/284,487, 2024
2024
Methods for generating mechanically-responsive cells and uses thereof
F Guilak, R Nims, L Pferdehirt
US Patent App. 18/282,761, 2024
2024
Synthetic Gene Circuits for Self-Regulating and Temporal Delivery of Anti-Inflammatory Biologic Drugs in Engineered Tissues
L Pferdehirt
Washington University in St. Louis, 2021
2021
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