A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues RJ Nims, L Pferdehirt, NB Ho, A Savadipour, J Lorentz, S Sohi, J Kassab, ... Science Advances 7 (5), eabd9858, 2021 | 75 | 2021 |
A synthetic gene circuit for self-regulating delivery of biologic drugs in engineered tissues L Pferdehirt, AK Ross, JM Brunger, F Guilak Tissue Engineering Part A 25 (9-10), 809-820, 2019 | 42 | 2019 |
Immunoengineering the next generation of arthritis therapies M Klimak, RJ Nims, L Pferdehirt, KH Collins, NS Harasymowicz, ... Acta biomaterialia 133, 74-86, 2021 | 41 | 2021 |
Quantitatively predictable control of cellular protein levels through proteasomal degradation W Zhao, L Pferdehirt, L Segatori ACS Synthetic Biology 7 (2), 540-552, 2018 | 41 | 2018 |
A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery YR Choi, KH Collins, LE Springer, L Pferdehirt, AK Ross, CL Wu, ... Science Advances 7 (36), eabj1414, 2021 | 37 | 2021 |
Designer stem cells: Genome engineering and the next generation of cell‐based therapies F Guilak, L Pferdehirt, AK Ross, YR Choi, KH Collins, RJ Nims, DB Katz, ... Journal of Orthopaedic Research® 37 (6), 1287-1293, 2019 | 36 | 2019 |
Mechanogenetics: harnessing mechanobiology for cellular engineering RJ Nims, L Pferdehirt, F Guilak Current opinion in biotechnology 73, 374-379, 2022 | 28 | 2022 |
Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation L Pferdehirt, AR Damato, M Dudek, QJ Meng, ED Herzog, F Guilak Science Advances 8 (21), eabj8892, 2022 | 17 | 2022 |
Hydrogel encapsulation of genome-engineered stem cells for long-term self-regulating anti-cytokine therapy KH Collins, L Pferdehirt, LS Saleh, A Savadipour, LE Springer, KL Lenz, ... Gels 9 (2), 169, 2023 | 11 | 2023 |
In vitro analysis of genome‐engineered muscle‐derived stem cells for autoregulated anti‐inflammatory and antifibrotic activity L Pferdehirt, P Guo, A Lu, M Huard, F Guilak, J Huard Journal of Orthopaedic Research® 40 (12), 2937-2946, 2022 | 1 | 2022 |
A synthetic chronogenetic gene circuit for programmed circadian drug delivery L Pferdehirt, AR Damato, KL Lenz, MF Gonzalez-Aponte, D Palmer, ... Nature Communications 16 (1), 1457, 2025 | | 2025 |
Compositions and methods for cell-based delivery systems F Guilak, L Pferdehirt US Patent App. 18/284,487, 2024 | | 2024 |
Methods for generating mechanically-responsive cells and uses thereof F Guilak, R Nims, L Pferdehirt US Patent App. 18/282,761, 2024 | | 2024 |
Synthetic Gene Circuits for Self-Regulating and Temporal Delivery of Anti-Inflammatory Biologic Drugs in Engineered Tissues L Pferdehirt Washington University in St. Louis, 2021 | | 2021 |