| Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents CF Cho, JM Wolfe, CM Fadzen, D Calligaris, K Hornburg, EA Chiocca, ... Nature communications 8 (1), 15623, 2017 | 301 | 2017 |
| Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery S Santagata, LS Eberlin, I Norton, D Calligaris, DR Feldman, JL Ide, X Liu, ... Proceedings of the National Academy of Sciences 111 (30), 11121-11126, 2014 | 300 | 2014 |
| Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis D Calligaris, D Caragacianu, X Liu, I Norton, CJ Thompson, ... Proceedings of the National Academy of Sciences 111 (42), 15184-15189, 2014 | 269 | 2014 |
| Coordinated splicing of regulatory detained introns within oncogenic transcripts creates an exploitable vulnerability in malignant glioma CJ Braun, M Stanciu, PL Boutz, JC Patterson, D Calligaris, F Higuchi, ... Cancer cell 32 (4), 411-426. e11, 2017 | 224 | 2017 |
| Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal NE Sounni, J Cimino, S Blacher, I Primac, A Truong, G Mazzucchelli, ... Cell metabolism 20 (2), 280-294, 2014 | 195 | 2014 |
| Label-free neurosurgical pathology with stimulated Raman imaging FK Lu, D Calligaris, OI Olubiyi, I Norton, W Yang, S Santagata, XS Xie, ... Cancer research 76 (12), 3451-3462, 2016 | 164 | 2016 |
| Mass spectrometry imaging as a tool for surgical decision‐making D Calligaris, I Norton, DR Feldman, JL Ide, IF Dunn, LS Eberlin, ... Journal of Mass Spectrometry 48 (11), 1178-1187, 2013 | 119 | 2013 |
| A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas Y Sun, JA Alberta, C Pilarz, D Calligaris, EJ Chadwick, SH Ramkissoon, ... Neuro-oncology 19 (6), 774-785, 2017 | 108 | 2017 |
| The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood–brain barrier in glioblastoma JL Pokorny, D Calligaris, SK Gupta, DO Iyekegbe Jr, D Mueller, ... Clinical cancer research 21 (8), 1916-1924, 2015 | 100 | 2015 |
| Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts is limited by ineffective drug penetration into the central nervous system KE Parrish, L Cen, J Murray, D Calligaris, S Kizilbash, RK Mittapalli, ... Molecular cancer therapeutics 14 (12), 2735-2743, 2015 | 98 | 2015 |
| Microtubule targeting agents: from biophysics to proteomics D Calligaris, P Verdier-Pinard, F Devred, C Villard, D Braguer, D Lafitte Cellular and molecular life sciences 67, 1089-1104, 2010 | 95 | 2010 |
| MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation D Calligaris, DR Feldman, I Norton, O Olubiyi, AN Changelian, ... Proceedings of the National Academy of Sciences 112 (32), 9978-9983, 2015 | 90 | 2015 |
| Advances in top-down proteomics for disease biomarker discovery D Calligaris, C Villard, D Lafitte Journal of proteomics 74 (7), 920-934, 2011 | 83 | 2011 |
| Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma EC Randall, KB Emdal, JK Laramy, M Kim, A Roos, D Calligaris, ... Nature communications 9 (1), 4904, 2018 | 80 | 2018 |
| Rapid discrimination of pediatric brain tumors by mass spectrometry imaging AR Clark, D Calligaris, MS Regan, D Pomeranz Krummel, JN Agar, ... Journal of Neuro-oncology 140, 269-279, 2018 | 61 | 2018 |
| Molecular typing of meningiomas by desorption electrospray ionization mass spectrometry imaging for surgical decision-making D Calligaris, DR Feldman, I Norton, PK Brastianos, IF Dunn, S Santagata, ... International journal of mass spectrometry 377, 690-698, 2015 | 56 | 2015 |
| Selected protein monitoring in histological sections by targeted MALDI-FTICR in-source decay imaging D Calligaris, R Longuespée, D Debois, D Asakawa, A Turtoi, ... Analytical chemistry 85 (4), 2117-2126, 2013 | 50 | 2013 |
| MALDI in-source decay of high mass protein isoforms: application to α-and β-tubulin variants D Calligaris, C Villard, L Terras, D Braguer, P Verdier-Pinard, D Lafitte Analytical chemistry 82 (14), 6176-6184, 2010 | 48 | 2010 |
| First in vivo testing of compounds targeting group 3 medulloblastomas using an implantable microdevice as a new paradigm for drug development O Jonas, D Calligaris, KR Methuku, MM Poe, JP Francois, F Tranghese, ... Journal of biomedical nanotechnology 12 (6), 1297-1302, 2016 | 46 | 2016 |
| Ultraviolet laser induced hydrogen transfer reaction: study of the first step of MALDI in-source decay mass spectrometry D Asakawa, D Calligaris, N Smargiasso, E De Pauw The Journal of Physical Chemistry B 117 (8), 2321-2327, 2013 | 44 | 2013 |
Sandro Santagata MD PhDBWH Pathology | HMS Laboratory of Systems Pharmacology | HMS Department of SysBioAdresse e-mail validée de bics.bwh.harvard.edu