| The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases JW Harper, GR Adami, N Wei, K Keyomarsi, SJ Elledge Cell 75 (4), 805-816, 1993 | 7891 | 1993 |
| The DNA damage response: making it safe to play with knives A Ciccia, SJ Elledge Molecular cell 40 (2), 179-204, 2010 | 5156 | 2010 |
| The DNA damage response: putting checkpoints in perspective BBS Zhou, SJ Elledge Nature 408 (6811), 433-439, 2000 | 4346 | 2000 |
| ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage S Matsuoka, BA Ballif, A Smogorzewska, ER McDonald III, KE Hurov, ... science 316 (5828), 1160-1166, 2007 | 3692 | 2007 |
| Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes L Zou, SJ Elledge Science 300 (5625), 1542-1548, 2003 | 3543 | 2003 |
| WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis WS El-Deiry, JW Harper, PM O'Connor, VE Velculescu, CE Canman, ... Cancer research 54 (5), 1169-1174, 1994 | 3026 | 1994 |
| Cell cycle checkpoints: preventing an identity crisis SJ Elledge Science 274 (5293), 1664-1672, 1996 | 2948 | 1996 |
| Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control C Deng, P Zhang, JW Harper, SJ Elledge, P Leder Cell 82 (4), 675-684, 1995 | 2818 | 1995 |
| Dicer is essential for mouse development E Bernstein, SY Kim, MA Carmell, EP Murchison, H Alcorn, MZ Li, AA Mills, ... Nature genetics 35 (3), 215-217, 2003 | 2617 | 2003 |
| Principles of cancer therapy: oncogene and non-oncogene addiction J Luo, NL Solimini, SJ Elledge Cell 136 (5), 823-837, 2009 | 2299 | 2009 |
| Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint Q Liu, S Guntuku, XS Cui, S Matsuoka, D Cortez, K Tamai, G Luo, ... Genes & development 14 (12), 1448-1459, 2000 | 2211 | 2000 |
| The DNA damage response: ten years after JW Harper, SJ Elledge Molecular cell 28 (5), 739-745, 2007 | 2183 | 2007 |
| The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. T Durfee, K Becherer, PL Chen, SH Yeh, Y Yang, AE Kilburn, WH Lee, ... Genes & development 7 (4), 555-569, 1993 | 2023 | 1993 |
| p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest V Dulić, WK Kaufmann, SJ Wilson, TD Tisty, E Lees, JW Harper, ... Cell 76 (6), 1013-1023, 1994 | 1982 | 1994 |
| A quantitative atlas of mitotic phosphorylation N Dephoure, C Zhou, J Villén, SA Beausoleil, CE Bakalarski, SJ Elledge, ... Proceedings of the National Academy of Sciences 105 (31), 10762-10767, 2008 | 1973 | 2008 |
| SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box C Bai, P Sen, K Hofmann, L Ma, M Goebl, JW Harper, SJ Elledge Cell 86 (2), 263-274, 1996 | 1872 | 1996 |
| Identification of host proteins required for HIV infection through a functional genomic screen AL Brass, DM Dykxhoorn, Y Benita, N Yan, A Engelman, RJ Xavier, ... science 319 (5865), 921-926, 2008 | 1815 | 2008 |
| Linkage of ATM to cell cycle regulation by the Chk2 protein kinase S Matsuoka, M Huang, SJ Elledge Science 282 (5395), 1893-1897, 1998 | 1795 | 1998 |
| Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 Y Sanchez, C Wong, RS Thoma, R Richman, Z Wu, H Piwnica-Worms, ... Science 277 (5331), 1497-1501, 1997 | 1774 | 1997 |
| Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex N Zheng, BA Schulman, L Song, JJ Miller, PD Jeffrey, P Wang, C Chu, ... Nature 416 (6882), 703-709, 2002 | 1769 | 2002 |
J.Wade HarperProfessor of Cell BiologyAdresse e-mail validée de hms.harvard.edu
