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Timothy R. Koves
Timothy R. Koves
Associate Professor of Medicine, Duke University
Adresse e-mail validée de dm.duke.edu
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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
22022008
The failing heart relies on ketone bodies as a fuel
G Aubert, OJ Martin, JL Horton, L Lai, RB Vega, TC Leone, T Koves, ...
Circulation 133 (8), 698-705, 2016
7022016
Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced …
TR Koves, P Li, J An, T Akimoto, D Slentz, O Ilkayeva, GL Dohm, Z Yan, ...
Journal of Biological Chemistry 280 (39), 33588-33598, 2005
5762005
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
J An, DM Muoio, M Shiota, Y Fujimoto, GW Cline, GI Shulman, TR Koves, ...
Nature medicine 10 (3), 268-274, 2004
5442004
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase
G Laurent, NJ German, AK Saha, VCJ de Boer, M Davies, TR Koves, ...
Molecular cell 50 (5), 686-698, 2013
4172013
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
JR Ussher, TR Koves, VJJ Cadete, L Zhang, JS Jaswal, SJ Swyrd, ...
Diabetes 59 (10), 2453-2464, 2010
4172010
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility
DM Muoio, RC Noland, JP Kovalik, SE Seiler, MN Davies, KL DeBalsi, ...
Cell metabolism 15 (5), 764-777, 2012
4142012
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
RC Noland, TR Koves, SE Seiler, H Lum, RM Lust, O Ilkayeva, ...
Journal of biological chemistry 284 (34), 22840-22852, 2009
4132009
Adipose acyl-CoA synthetase-1 directs fatty acids toward β-oxidation and is required for cold thermogenesis
JM Ellis, LO Li, PC Wu, TR Koves, O Ilkayeva, RD Stevens, SM Watkins, ...
Cell metabolism 12 (1), 53-64, 2010
3792010
Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat
SE Hemby, C Co, TR Koves, JE Smith, SI Dworkin
Psychopharmacology 133, 7-16, 1997
3471997
Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach
L Lai, TC Leone, MP Keller, OJ Martin, AT Broman, J Nigro, K Kapoor, ...
Circulation: Heart Failure 7 (6), 1022-1031, 2014
2882014
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and β-oxidation and alters phospholipid fatty acid composition
LO Li, JM Ellis, HA Paich, S Wang, N Gong, G Altshuller, RJ Thresher, ...
Journal of Biological Chemistry 284 (41), 27816-27826, 2009
2632009
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism
TR Koves, RC Noland, AL Bates, ST Henes, DM Muoio, RN Cortright
American Journal of Physiology-Cell Physiology 288 (5), C1074-C1082, 2005
2152005
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs fatty acid oxidation and induces cardiac hypertrophy
JM Ellis, SM Mentock, MA DePetrillo, TR Koves, S Sen, SM Watkins, ...
Molecular and cellular biology 31 (6), 1252-1262, 2011
2122011
Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle
A Khodabukus, L Madden, NK Prabhu, TR Koves, CP Jackman, ...
Biomaterials 198, 259-269, 2019
1922019
Measurement of fatty acid oxidation rates in animal tissues and cell lines
FK Huynh, MF Green, TR Koves, MD Hirschey
Methods in enzymology 542, 391-405, 2014
1822014
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease
DM Muoio, TR Koves
Applied Physiology, Nutrition, and Metabolism 32 (5), 874-883, 2007
1772007
Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness
KM Huffman, TR Koves, MJ Hubal, H Abouassi, N Beri, LA Bateman, ...
Diabetologia 57, 2282-2295, 2014
1522014
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults
CL Kien, JY Bunn, ME Poynter, R Stevens, J Bain, O Ikayeva, ...
Diabetes 62 (4), 1054-1063, 2013
1522013
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet–induced obese mice lacking malonyl CoA decarboxylase
JR Ussher, TR Koves, JS Jaswal, L Zhang, O Ilkayeva, JRB Dyck, ...
Diabetes 58 (8), 1766-1775, 2009
1462009
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