Scalable mRNA and siRNA lipid nanoparticle production using a parallelized microfluidic device SJ Shepherd, CC Warzecha, S Yadavali, R El-Mayta, MG Alameh, ... Nano Letters 21 (13), 5671-5680, 2021 | 200 | 2021 |
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver R Zhang, R El-Mayta, TJ Murdoch, CC Warzecha, MM Billingsley, ... Biomaterials Science 9 (4), 1449-1463, 2021 | 176 | 2021 |
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening PPG Guimaraes, R Zhang, R Spektor, M Tan, A Chung, MM Billingsley, ... Journal of Controlled Release 316, 404-417, 2019 | 166 | 2019 |
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis X Han, N Gong, L Xue, MM Billingsley, R El-Mayta, SJ Shepherd, ... Nature Communications 14 (1), 75, 2023 | 90 | 2023 |
In vivo mRNA CAR T cell engineering via targeted ionizable lipid nanoparticles with extrahepatic tropism MM Billingsley, N Gong, AJ Mukalel, AS Thatte, R El‐Mayta, SK Patel, ... Small 20 (11), 2304378, 2024 | 54 | 2024 |
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines SJ Shepherd, X Han, AJ Mukalel, R El-Mayta, AS Thatte, J Wu, MS Padilla, ... Proceedings of the National Academy of Sciences 120 (33), e2303567120, 2023 | 46 | 2023 |
Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy K Butowska, X Han, N Gong, R El-Mayta, RM Haley, L Xue, W Zhong, ... Acta Pharmaceutica Sinica B 13 (4), 1429-1437, 2023 | 42 | 2023 |
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models L Xue, AG Hamilton, G Zhao, Z Xiao, R El-Mayta, X Han, N Gong, X Xiong, ... Nature Communications 15 (1), 1884, 2024 | 38 | 2024 |
Delivery technologies to engineer natural killer cells for cancer immunotherapy R El-Mayta, Z Zhang, AG Hamilton, MJ Mitchell Cancer Gene Therapy 28 (9), 947-959, 2021 | 37 | 2021 |
In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity N Gong, X Han, L Xue, R El-Mayta, AE Metzloff, MM Billingsley, ... Nature Materials 22 (12), 1571-1580, 2023 | 32 | 2023 |
A Nanoparticle Platform for Accelerated In Vivo Oral Delivery Screening of Nucleic Acids R El‐Mayta, R Zhang, SJ Shepherd, F Wang, MM Billingsley, V Dudkin, ... Advanced Therapeutics 4 (1), 2000111, 2021 | 31 | 2021 |
In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy PPG Guimarães, CG Figueroa-Espada, RS Riley, N Gong, L Xue, ... Proceedings of the National Academy of Sciences 120 (25), e2215711120, 2023 | 30 | 2023 |
Enhancing in situ cancer vaccines using delivery technologies N Gong, MG Alameh, R El-Mayta, L Xue, D Weissman, MJ Mitchell Nature Reviews Drug Discovery 23 (8), 607-625, 2024 | 21 | 2024 |
Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery SK Patel, MM Billingsley, AJ Mukalel, AS Thatte, AG Hamilton, N Gong, ... Theranostics 14 (1), 1, 2024 | 20 | 2024 |
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors X Han, J Xu, Y Xu, MG Alameh, L Xue, N Gong, R El-Mayta, R Palanki, ... Nature Communications 15 (1), 1762, 2024 | 17 | 2024 |
Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction M Huang, F Yang, D Zhang, M Lin, H Duan, R El-Mayta, L Zhang, L Qin, ... Nature Cardiovascular Research 1 (4), 372-388, 2022 | 14 | 2022 |
Testing the in vitro and in vivo efficiency of mRNA-lipid nanoparticles formulated by microfluidic mixing R El-Mayta, MS Padilla, MM Billingsley, X Han, MJ Mitchell Journal of Visualized Experiments, 2023 | 13 | 2023 |
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo X Han, MG Alameh, N Gong, L Xue, M Ghattas, G Bojja, J Xu, G Zhao, ... Nature chemistry 16 (10), 1687-1697, 2024 | 12 | 2024 |
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma F Yang, MN Akhtar, D Zhang, R El-Mayta, J Shin, JF Dorsey, L Zhang, ... Science Advances 10 (9), eadj4678, 2024 | 11 | 2024 |
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager N Gong, X Han, L Xue, MM Billingsley, X Huang, R El-Mayta, J Qin, ... Nature biomedical engineering 8 (5), 513-528, 2024 | 9 | 2024 |