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| Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals MS Levine, B Bakker, B Boeckx, J Moyett, J Lu, B Vitre, DC Spierings, ... Developmental cell 40 (3), 313-322. e5, 2017 | 393 | 2017 |
| Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis D Spierings, G McStay, M Saleh, C Bender, J Chipuk, U Maurer, ... Science 310 (5745), 66-67, 2005 | 375 | 2005 |
| Tissue distribution of the death ligand TRAIL and its receptors DC Spierings, EG de Vries, E Vellenga, FA van den Heuvel, JJ Koornstra, ... Journal of Histochemistry & Cytochemistry 52 (6), 821-831, 2004 | 328 | 2004 |
| Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies B Bakker, A Taudt, ME Belderbos, D Porubsky, DCJ Spierings, ... Genome biology 17, 1-15, 2016 | 261 | 2016 |
| Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids ACF Bolhaqueiro, B Ponsioen, B Bakker, SJ Klaasen, E Kucukkose, ... Nature genetics 51 (5), 824-834, 2019 | 222 | 2019 |
| cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers C Hong, M Schubert, AE Tijhuis, M Requesens, M Roorda, ... Nature 607 (7918), 366-373, 2022 | 216 | 2022 |
| Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition Y Cohen-Sharir, JM McFarland, M Abdusamad, C Marquis, SV Bernhard, ... Nature 590 (7846), 486-491, 2021 | 216 | 2021 |
| Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors DCJ Spierings, EGE de Vries, W Timens, HJM Groen, HM Boezen, ... Clinical cancer research 9 (9), 3397-3405, 2003 | 191 | 2003 |
| p53 prohibits propagation of chromosome segregation errors that produce structural aneuploidies M Soto, JA Raaijmakers, B Bakker, DCJ Spierings, PM Lansdorp, F Foijer, ... Cell reports 19 (12), 2423-2431, 2017 | 170 | 2017 |
| Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer’s disease neurons H van den Bos, DCJ Spierings, A Taudt, B Bakker, D Porubský, ... Genome biology 17, 1-9, 2016 | 165 | 2016 |
| Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy MR Ippolito, V Martis, S Martin, AE Tijhuis, C Hong, R Wardenaar, ... Developmental cell 56 (17), 2440-2454. e6, 2021 | 147 | 2021 |
| Improved assembly and variant detection of a haploid human genome using single‐molecule, high‐fidelity long reads MR Vollger, GA Logsdon, PA Audano, A Sulovari, D Porubsky, P Peluso, ... Annals of human genetics 84 (2), 125-140, 2020 | 138 | 2020 |
| Non-random mis-segregation of human chromosomes JT Worrall, N Tamura, A Mazzagatti, N Shaikh, T van Lingen, B Bakker, ... Cell reports 23 (11), 3366-3380, 2018 | 132 | 2018 |
| Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs AD Sanders, E Falconer, M Hills, DCJ Spierings, PM Lansdorp Nature Protocols 12 (6), 1151-1176, 2017 | 131 | 2017 |
| Genetic instability from a single S phase after whole-genome duplication S Gemble, R Wardenaar, K Keuper, N Srivastava, M Nano, AS Macé, ... Nature 604 (7904), 146-151, 2022 | 114 | 2022 |
| DNA replication vulnerabilities render ovarian cancer cells sensitive to poly (ADP-ribose) glycohydrolase inhibitors N Pillay, A Tighe, L Nelson, S Littler, C Coulson-Gilmer, N Bah, A Golder, ... Cancer Cell 35 (3), 519-533. e8, 2019 | 112 | 2019 |
| BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes N van Wietmarschen, S Merzouk, N Halsema, DCJ Spierings, V Guryev, ... Nature communications 9 (1), 271, 2018 | 112 | 2018 |
| Human-specific tandem repeat expansion and differential gene expression during primate evolution A Sulovari, R Li, PA Audano, D Porubsky, MR Vollger, GA Logsdon, ... Proceedings of the National Academy of Sciences 116 (46), 23243-23253, 2019 | 108 | 2019 |
| Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis AJ Stel, B Ten Cate, S Jacobs, JW Kok, DCJ Spierings, M Dondorff, ... The Journal of Immunology 178 (4), 2287-2295, 2007 | 105 | 2007 |
