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Evan M Koch
Evan M Koch
Harvard Medical School
Potvrđena adresa e-pošte na hms.harvard.edu - Početna stranica
Naslov
Citirano
Citirano
Godina
Population-specific causal disease effect sizes in functionally important regions impacted by selection
H Shi, S Gazal, M Kanai, EM Koch, AP Schoech, KM Siewert, SS Kim, ...
Nature communications 12 (1), 1098, 2021
1222021
Population sequencing data reveal a compendium of mutational processes in the human germ line
VB Seplyarskiy, RA Soldatov, E Koch, RJ McGinty, JM Goldmann, ...
Science 373 (6558), 1030-1035, 2021
662021
Long range linkage disequilibrium across the human genome
E Koch, M Ristroph, M Kirkpatrick
PloS one 8 (12), e80754, 2013
642013
De novo mutation rate estimation in wolves of known pedigree
EM Koch, RM Schweizer, TM Schweizer, DR Stahler, DW Smith, ...
Molecular Biology and Evolution 36 (11), 2536-2547, 2019
602019
Maintenance of adaptive dynamics and no detectable load in a range-edge outcrossing plant population
M Takou, T Hämälä, EM Koch, KA Steige, H Dittberner, L Yant, M Genete, ...
Molecular Biology and Evolution 38 (5), 1820-1836, 2021
33*2021
Polygenic adaptation of rosette growth in Arabidopsis thaliana
B Wieters, KA Steige, F He, EM Koch, SE Ramos-Onsins, H Gu, YL Guo, ...
Plos Genetics 17 (1), e1008748, 2021
23*2021
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription
V Seplyarskiy, EM Koch, DJ Lee, JS Lichtman, HH Luan, SR Sunyaev
Nature genetics 55 (12), 2235-2242, 2023
222023
Maintenance of complex trait variation: classic theory and modern data
EM Koch, SR Sunyaev
Frontiers in genetics 12, 763363, 2021
192021
A sequential coalescent algorithm for chromosomal inversions
S Peischl, E Koch, RF Guerrero, M Kirkpatrick
Heredity 111 (3), 200-209, 2013
192013
Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts
AT Ciota, EM Koch, GG Willsey, LJ Davis, GVS Jerzak, DJ Ehrbar, ...
Infection, Genetics and Evolution 11 (2), 460-468, 2011
152011
A temporal perspective on the interplay of demography and selection on deleterious variation in humans
E Koch, J Novembre
G3: Genes, Genomes, Genetics 7 (3), 1027-1037, 2017
122017
Recurrent mutation in the ancestry of a rare variant
J Wakeley, WT Fan, E Koch, S Sunyaev
Genetics 224 (3), iyad049, 2023
112023
Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus
N Commins, MR Sullivan, K McGowen, EM Koch, EJ Rubin, M Farhat
Proceedings of the National Academy of Sciences 120 (22), e2302033120, 2023
102023
The effects of demography and genetics on the neutral distribution of quantitative traits
EM Koch
Genetics 211 (4), 1371-1394, 2019
92019
Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traits
E Koch, NJ Connally, N Baya, MP Reeve, M Daly, B Neale, ES Lander, ...
bioRxiv, 2024.06. 19.599789, 2024
62024
Pervasive correlations between causal disease effects of proximal SNPs vary with functional annotations and implicate stabilizing selection
MJ Zhang, A Durvasula, C Chiang, EM Koch, BJ Strober, H Shi, ...
Research Square, rs. 3. rs-3707248, 2023
32023
Demographic and Viral-Genetic Analyses of COVID-19 Severity in Bahrain Identify Local Risk Factors and a Protective Effect of Polymerase Mutations
EM Koch, J Du, M Dressner, HE Alwasti, Z Al Taif, F Shehab, ...
medRxiv, 2022.08. 13.22278740, 2023
12023
Surfing waves of data in San Diego: sophisticated analyses provide a broad view of human genetic diversity
M Reppell, E Koch, BM Peter, J Novembre
Genome Biology 15, 1-3, 2014
12014
Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia
V Seplyarskiy, MA Moldovan, EM Koch, P Kar, MDC Neville, R Rahbari, ...
medRxiv, 2025.01. 03.25319979, 2025
2025
Deciphering the impact of genomic variation on function
E Van Buren, A Price, A Ham, A Hall, A Carpenter, A Yadav, A Durvasula, ...
Nature, 2024
2024
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