Population-specific causal disease effect sizes in functionally important regions impacted by selection H Shi, S Gazal, M Kanai, EM Koch, AP Schoech, KM Siewert, SS Kim, ... Nature communications 12 (1), 1098, 2021 | 122 | 2021 |
Population sequencing data reveal a compendium of mutational processes in the human germ line VB Seplyarskiy, RA Soldatov, E Koch, RJ McGinty, JM Goldmann, ... Science 373 (6558), 1030-1035, 2021 | 66 | 2021 |
Long range linkage disequilibrium across the human genome E Koch, M Ristroph, M Kirkpatrick PloS one 8 (12), e80754, 2013 | 64 | 2013 |
De novo mutation rate estimation in wolves of known pedigree EM Koch, RM Schweizer, TM Schweizer, DR Stahler, DW Smith, ... Molecular Biology and Evolution 36 (11), 2536-2547, 2019 | 60 | 2019 |
Maintenance of adaptive dynamics and no detectable load in a range-edge outcrossing plant population M Takou, T Hämälä, EM Koch, KA Steige, H Dittberner, L Yant, M Genete, ... Molecular Biology and Evolution 38 (5), 1820-1836, 2021 | 33* | 2021 |
Polygenic adaptation of rosette growth in Arabidopsis thaliana B Wieters, KA Steige, F He, EM Koch, SE Ramos-Onsins, H Gu, YL Guo, ... Plos Genetics 17 (1), e1008748, 2021 | 23* | 2021 |
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription V Seplyarskiy, EM Koch, DJ Lee, JS Lichtman, HH Luan, SR Sunyaev Nature genetics 55 (12), 2235-2242, 2023 | 22 | 2023 |
Maintenance of complex trait variation: classic theory and modern data EM Koch, SR Sunyaev Frontiers in genetics 12, 763363, 2021 | 19 | 2021 |
A sequential coalescent algorithm for chromosomal inversions S Peischl, E Koch, RF Guerrero, M Kirkpatrick Heredity 111 (3), 200-209, 2013 | 19 | 2013 |
Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts AT Ciota, EM Koch, GG Willsey, LJ Davis, GVS Jerzak, DJ Ehrbar, ... Infection, Genetics and Evolution 11 (2), 460-468, 2011 | 15 | 2011 |
A temporal perspective on the interplay of demography and selection on deleterious variation in humans E Koch, J Novembre G3: Genes, Genomes, Genetics 7 (3), 1027-1037, 2017 | 12 | 2017 |
Recurrent mutation in the ancestry of a rare variant J Wakeley, WT Fan, E Koch, S Sunyaev Genetics 224 (3), iyad049, 2023 | 11 | 2023 |
Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus N Commins, MR Sullivan, K McGowen, EM Koch, EJ Rubin, M Farhat Proceedings of the National Academy of Sciences 120 (22), e2302033120, 2023 | 10 | 2023 |
The effects of demography and genetics on the neutral distribution of quantitative traits EM Koch Genetics 211 (4), 1371-1394, 2019 | 9 | 2019 |
Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traits E Koch, NJ Connally, N Baya, MP Reeve, M Daly, B Neale, ES Lander, ... bioRxiv, 2024.06. 19.599789, 2024 | 6 | 2024 |
Pervasive correlations between causal disease effects of proximal SNPs vary with functional annotations and implicate stabilizing selection MJ Zhang, A Durvasula, C Chiang, EM Koch, BJ Strober, H Shi, ... Research Square, rs. 3. rs-3707248, 2023 | 3 | 2023 |
Demographic and Viral-Genetic Analyses of COVID-19 Severity in Bahrain Identify Local Risk Factors and a Protective Effect of Polymerase Mutations EM Koch, J Du, M Dressner, HE Alwasti, Z Al Taif, F Shehab, ... medRxiv, 2022.08. 13.22278740, 2023 | 1 | 2023 |
Surfing waves of data in San Diego: sophisticated analyses provide a broad view of human genetic diversity M Reppell, E Koch, BM Peter, J Novembre Genome Biology 15, 1-3, 2014 | 1 | 2014 |
Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia V Seplyarskiy, MA Moldovan, EM Koch, P Kar, MDC Neville, R Rahbari, ... medRxiv, 2025.01. 03.25319979, 2025 | | 2025 |
Deciphering the impact of genomic variation on function E Van Buren, A Price, A Ham, A Hall, A Carpenter, A Yadav, A Durvasula, ... Nature, 2024 | | 2024 |