| Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8, 9-dihydrofuro [3, 2-c] pyrazolo [1, 5-a] pyridines as melatonin receptor (MT1/MT2) ligands T Koike, T Takai, Y Hoashi, M Nakayama, Y Kosugi, M Nakashima, ... Journal of medicinal chemistry 54 (12), 4207-4218, 2011 | 76 | 2011 |
| 1,6-Dihydro-2H-indeno[5,4-b]furan Derivatives: Design, Synthesis, and Pharmacological Characterization of a Novel Class of Highly Potent MT2-Selective Agonists T Koike, Y Hoashi, T Takai, M Nakayama, N Yukuhiro, T Ishikawa, K Hirai, ... Journal of medicinal chemistry 54 (9), 3436-3444, 2011 | 60 | 2011 |
| Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol … K Sato, H Takahagi, T Yoshikawa, S Morimoto, T Takai, K Hidaka, ... Journal of Medicinal Chemistry 58 (9), 3892-3909, 2015 | 40 | 2015 |
| Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design T Yasui, T Yamamoto, N Sakai, K Asano, T Takai, Y Yoshitomi, M Davis, ... Bioorganic & Medicinal Chemistry 25 (17), 4876-4886, 2017 | 37 | 2017 |
| Discovery of 1, 2, 3, 4-tetrahydropyrimido [1, 2-a] benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists T Kojima, M Mochizuki, T Takai, Y Hoashi, S Morimoto, M Seto, ... Bioorganic & Medicinal Chemistry 26 (9), 2229-2250, 2018 | 33 | 2018 |
| Facile synthesis of (−)-tabtoxinine-β-lactam and its (3′ R)-isomer H Kiyota, T Takai, M Saitoh, O Nakayama, T Oritani, S Kuwahara Tetrahedron letters 45 (44), 8191-8194, 2004 | 32 | 2004 |
| Discovery and optimization of 1, 7-disubstituted-2, 2-dimethyl-2, 3-dihydroquinazolin-4 (1H)-ones as potent and selective PKCθ inhibitors T Katoh, T Takai, T Yukawa, T Tsukamoto, E Watanabe, H Mototani, ... Bioorganic & Medicinal Chemistry 24 (11), 2466-2475, 2016 | 31 | 2016 |
| Synthesis of 4-aza analog of ramelteon: a novel tricyclic 1, 6, 7, 8-tetrahydro-2H-cyclopenta [d] furo [2, 3-b] pyridine derivative as melatonin receptor ligand T Koike, Y Hoashi, T Takai, O Uchikawa Tetrahedron letters 52 (23), 3009-3011, 2011 | 24 | 2011 |
| Structure-based design, synthesis, and biological evaluation of imidazo [1, 2-b] pyridazine-based p38 MAP kinase inhibitors A Kaieda, M Takahashi, T Takai, M Goto, T Miyazaki, Y Hori, S Unno, ... Bioorganic & Medicinal Chemistry 26 (3), 647-660, 2018 | 23 | 2018 |
| Synthesis of pyrazolo [1, 5-a] pyridines by thermal intramolecular cyclization Y Hoashi, T Takai, E Kotani, T Koike Tetrahedron Letters 54 (17), 2199-2202, 2013 | 21 | 2013 |
| Discovery of novel 5, 6, 7, 8-tetrahydro [1, 2, 4] triazolo [4, 3-a] pyridine derivatives as γ-secretase modulators T Takai, Y Hoashi, Y Tomata, S Morimoto, M Nakamura, T Watanabe, ... Bioorganic & Medicinal Chemistry Letters 25 (19), 4245-4249, 2015 | 18 | 2015 |
| Tricyclic compounds and use thereof K Aso, K Kobayashi, T Takai, T Kojima, K Tokumaru, M Mochizuki, ... US Patent 8,785,460, 2014 | 14 | 2014 |
| Discovery of novel 5, 6, 7, 8-tetrahydro [1, 2, 4] triazolo [4, 3-a] pyridine derivatives as γ-secretase modulators (Part 2) T Takai, T Koike, M Nakamura, Y Kajita, T Yamashita, N Taya, ... Bioorganic & Medicinal Chemistry 24 (14), 3192-3206, 2016 | 13 | 2016 |
| Synthesis of (-)-tabtoxinine-β-lactam, the phytotoxin of tobacco wildfire disease H Kiyota, T Takai, Y Shimasaki, M Saitoh, O Nakayama, T Takada, ... Synthesis 2007 (16), 2471-2480, 2007 | 13 | 2007 |
| Discovery of a potent and orally bioavailable melatonin receptor agonist Y Hoashi, T Takai, Y Kosugi, M Nakashima, M Nakayama, K Hirai, ... Journal of Medicinal Chemistry 64 (6), 3059-3074, 2021 | 9 | 2021 |
| Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ42 production T Takai, T Koike, E Honda, Y Kajita, M Nakamura, S Morimoto, Y Hoashi, ... Bioorganic & Medicinal Chemistry 23 (9), 1923-1934, 2015 | 9 | 2015 |
| Practical application of 3-substituted-2, 6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors T Katoh, Y Tomata, M Setoh, S Sasaki, T Takai, Y Yoshitomi, T Yukawa, ... Bioorganic & Medicinal Chemistry Letters 27 (11), 2497-2501, 2017 | 8 | 2017 |
| Tricyclic compound and pharmaceutical use thereof O Uchikawa, T Koike, T Takai, Y Hoashi US Patent 8,247,429, 2012 | 8 | 2012 |
| Syntheses and odour descriptions of cyclopropanated compounds 3.1 Analogues of leaf alcohol, its esters and leaf acetal H Kiyota, E Higashi, T Takai, T Oritani, S Kuwahara Flavour and fragrance journal 17 (3), 227-231, 2002 | 6 | 2002 |
| An integrated temperature and humidity sensor T Yamamoto, K Murakami, H Shimizu, T Takai Proceedings of the 4th International Conference on Solid State Sensors and …, 1987 | 5 | 1987 |