| Tau suppression in a neurodegenerative mouse model improves memory function K Santacruz, J Lewis, T Spires, J Paulson, L Kotilinek, M Ingelsson, ... Science 309 (5733), 476-481, 2005 | 2400 | 2005 |
| Propagation of tau pathology in a model of early Alzheimer's disease A De Calignon, M Polydoro, M Suárez-Calvet, C William, DH Adamowicz, ... Neuron 73 (4), 685-697, 2012 | 1598 | 2012 |
| Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease M Meyer-Luehmann, TL Spires-Jones, C Prada, M Garcia-Alloza, ... Nature 451 (7179), 720-724, 2008 | 1253 | 2008 |
| The intersection of amyloid beta and tau at synapses in Alzheimer’s disease TL Spires-Jones, BT Hyman Neuron 82 (4), 756-771, 2014 | 1251 | 2014 |
| Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques RM Koffie, M Meyer-Luehmann, T Hashimoto, KW Adams, ML Mielke, ... Proceedings of the National Academy of Sciences 106 (10), 4012-4017, 2009 | 1032 | 2009 |
| Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy TL Spires, M Meyer-Luehmann, EA Stern, PJ McLean, J Skoch, ... Journal of Neuroscience 25 (31), 7278-7287, 2005 | 667 | 2005 |
| Caspase activation precedes and leads to tangles A De Calignon, LM Fox, R Pitstick, GA Carlson, BJ Bacskai, ... Nature 464 (7292), 1201-1204, 2010 | 662 | 2010 |
| Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo TA Fulga, I Elson-Schwab, V Khurana, ML Steinhilb, TL Spires, BT Hyman, ... Nature cell biology 9 (2), 139-148, 2007 | 527 | 2007 |
| The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system HC Tai, A Serrano-Pozo, T Hashimoto, MP Frosch, TL Spires-Jones, ... The American journal of pathology 181 (4), 1426-1435, 2012 | 502 | 2012 |
| Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy TL Spires, JD Orne, K SantaCruz, R Pitstick, GA Carlson, KH Ashe, ... The American journal of pathology 168 (5), 1598-1607, 2006 | 472 | 2006 |
| Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism TL Spires, HE Grote, NK Varshney, PM Cordery, A Van Dellen, ... Journal of Neuroscience 24 (9), 2270-2276, 2004 | 435 | 2004 |
| Amyloid β induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation HY Wu, E Hudry, T Hashimoto, K Kuchibhotla, A Rozkalne, Z Fan, ... Journal of Neuroscience 30 (7), 2636-2649, 2010 | 434 | 2010 |
| Tau pathophysiology in neurodegeneration: a tangled issue TL Spires-Jones, WH Stoothoff, A De Calignon, PB Jones, BT Hyman Trends in neurosciences 32 (3), 150-159, 2009 | 421 | 2009 |
| Interactions of pathological proteins in neurodegenerative diseases TL Spires-Jones, J Attems, DR Thal Acta neuropathologica 134, 187-205, 2017 | 410 | 2017 |
| Tau association with synaptic vesicles causes presynaptic dysfunction L Zhou, J McInnes, K Wierda, M Holt, AG Herrmann, RJ Jackson, ... Nature communications 8 (1), 1-13, 2017 | 407 | 2017 |
| The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics SA Kent, TL Spires-Jones, CS Durrant Acta neuropathologica 140 (4), 417-447, 2020 | 379 | 2020 |
| Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β RM Koffie, T Hashimoto, HC Tai, KR Kay, A Serrano-Pozo, D Joyner, ... Brain 135 (7), 2155-2168, 2012 | 376 | 2012 |
| Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide T Hashimoto, A Serrano-Pozo, Y Hori, KW Adams, S Takeda, AO Banerji, ... Journal of Neuroscience 32 (43), 15181-15192, 2012 | 364 | 2012 |
| Alzheimer's disease: synapses gone cold RM Koffie, BT Hyman, TL Spires-Jones Molecular neurodegeneration 6, 1-9, 2011 | 364 | 2011 |
| Transgenic models of Alzheimer's disease: learning from animals TL Spires, BT Hyman NeuroRx 2 (3), 423-437, 2005 | 315 | 2005 |