Novel strategies to address the challenges in top-down proteomics JA Melby, DS Roberts, EJ Larson, KA Brown, EF Bayne, S Jin, Y Ge Journal of the American Society for Mass Spectrometry 32 (6), 1278-1294, 2021 | 163 | 2021 |
Top-down proteomics: challenges, innovations, and applications in basic and clinical research KA Brown, JA Melby, DS Roberts, Y Ge Expert review of proteomics 17 (10), 719-733, 2020 | 127 | 2020 |
MASH explorer: a universal software environment for top-down proteomics Z Wu, DS Roberts, JA Melby, K Wenger, M Wetzel, Y Gu, SG Ramanathan, ... Journal of proteome research 19 (9), 3867-3876, 2020 | 81 | 2020 |
Structural O-glycoform heterogeneity of the SARS-CoV-2 spike protein receptor-binding domain revealed by top-down mass spectrometry DS Roberts, M Mann, JA Melby, EJ Larson, Y Zhu, AR Brasier, S Jin, Y Ge Journal of the American Chemical Society 143 (31), 12014-12024, 2021 | 69 | 2021 |
Ultrafast and reproducible proteomics from small amounts of heart tissue enabled by Azo and timsTOF pro TJ Aballo, DS Roberts, JA Melby, KM Buck, KA Brown, Y Ge Journal of Proteome Research 20 (8), 4203-4211, 2021 | 57 | 2021 |
High-throughput multi-attribute analysis of antibody-drug conjugates enabled by trapped ion mobility spectrometry and top-down mass spectrometry EJ Larson, DS Roberts, JA Melby, KM Buck, Y Zhu, S Zhou, L Han, ... Analytical chemistry 93 (29), 10013-10021, 2021 | 41 | 2021 |
High sensitivity top–down proteomics captures single muscle cell heterogeneity in large proteoforms JA Melby, KA Brown, ZR Gregorich, DS Roberts, EA Chapman, LE Ehlers, ... Proceedings of the National Academy of Sciences 120 (19), e2222081120, 2023 | 36 | 2023 |
Functionally integrated top-down proteomics for standardized assessment of human induced pluripotent stem cell-derived engineered cardiac tissues JA Melby, WJ de Lange, J Zhang, DS Roberts, SD Mitchell, T Tucholski, ... Journal of proteome research 20 (2), 1424-1433, 2021 | 23 | 2021 |
Defining the sarcomeric proteoform landscape in ischemic cardiomyopathy by top-down proteomics EA Chapman, TJ Aballo, JA Melby, T Zhou, SJ Price, KJ Rossler, I Lei, ... Journal of proteome research 22 (3), 931-941, 2023 | 21 | 2023 |
MASH Native: a unified solution for native top-down proteomics data processing EJ Larson, MR Pergande, ME Moss, KJ Rossler, RK Wenger, B Krichel, ... Bioinformatics 39 (6), btad359, 2023 | 18 | 2023 |
Top-down proteomics reveals myofilament proteoform heterogeneity among various rat skeletal muscle tissues JA Melby, Y Jin, Z Lin, T Tucholski, Z Wu, ZR Gregorich, GM Diffee, Y Ge Journal of proteome research 19 (1), 446-454, 2019 | 16 | 2019 |
Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics EA Chapman, DS Roberts, TN Tiambeng, J Andrews, MD Wang, ... Nature Communications 14 (1), 8400, 2023 | 6 | 2023 |
Comprehensive characterization of endogenous phospholamban proteoforms enabled by photocleavable surfactant and top-down proteomics HT Rogers, DS Roberts, EJ Larson, JA Melby, KJ Rossler, AV Carr, ... Analytical Chemistry 95 (35), 13091-13100, 2023 | 6 | 2023 |
Size exclusion chromatography strategies and MASH explorer for large proteoform characterization TN Tiambeng, Z Wu, JA Melby, Y Ge Proteoform Identification: Methods and Protocols, 15-30, 2022 | 6 | 2022 |
Rbm20 ablation is associated with changes in the expression of titin-interacting and metabolic proteins EJ Larson, ZR Gregorich, Y Zhang, BH Li, TJ Aballo, JA Melby, Y Ge, ... Molecular omics 18 (7), 627-634, 2022 | 5 | 2022 |
Small-Scale Serial Size Exclusion Chromatography (s3SEC) for High Sensitivity Top-Down Proteomics of Large Proteoforms HT Rogers, JA Melby, LE Ehlers, MS Fischer, EJ Larson, Z Gao, ... Analytical Chemistry 96 (7), 2748-2753, 2024 | 4 | 2024 |
Lactate-and immunomagnetic-purified hiPSC–derived cardiomyocytes generate comparable engineered cardiac tissue constructs KJ Rossler, WJ De Lange, MW Mann, TJ Aballo, JA Melby, J Zhang, ... JCI insight 9 (1), 2024 | 2 | 2024 |
Quantum Cascade Laser Infrared Spectroscopy for Glycan Analysis of Glycoprotein Solutions SM Kim, YR Chang, J Melby, YJ Kim, D Davis, YJ Lee Analytical Chemistry 96 (32), 13120-13130, 2024 | 1 | 2024 |
Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics EA Chapman, DS Roberts, TN Tiambeng, J Andrews, MD Wang, ... Research Square, 2023 | 1 | 2023 |
Novel Strategies to Address the Challenge of Sensitivity in Top-down Proteomics JA Melby The University of Wisconsin-Madison, 2023 | | 2023 |