An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. JAL Flynn, J Chan, KJ Triebold, DK Dalton, TA Stewart, BR Bloom The Journal of experimental medicine 178 (6), 2249-2254, 1993 | 3202 | 1993 |
Immunology of tuberculosis JAL Flynn, J Chan Annual review of immunology 19 (1), 93-129, 2001 | 2920 | 2001 |
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues CGK Ziegler, SJ Allon, SK Nyquist, IM Mbano, VN Miao, CN Tzouanas, ... Cell 181 (5), 1016-1035. e19, 2020 | 2498 | 2020 |
Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice JAL Flynn, MM Goldstein, J Chan, KJ Triebold, K Pfeffer, CJ Lowenstein, ... Immunity 2 (6), 561-572, 1995 | 2242 | 1995 |
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies CE Barry 3rd, HI Boshoff, V Dartois, T Dick, S Ehrt, JA Flynn, ... Nature Reviews Microbiology 7 (12), 845-855, 2009 | 1732 | 2009 |
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. JAL Flynn, MM Goldstein, KJ Triebold, B Koller, BR Bloom Proceedings of the National Academy of Sciences 89 (24), 12013-12017, 1992 | 1091 | 1992 |
IL-17 production is dominated by γδ T cells rather than CD4 T cells during Mycobacterium tuberculosis infection E Lockhart, AM Green, JAL Flynn The Journal of Immunology 177 (7), 4662-4669, 2006 | 1052 | 2006 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates LE Via, PL Lin, SM Ray, J Carrillo, SS Allen, SY Eum, K Taylor, E Klein, ... Infection and immunity 76 (6), 2333-2340, 2008 | 770 | 2008 |
Tuberculosis: latency and reactivation JAL Flynn, J Chan Infection and immunity 69 (7), 4195-4201, 2001 | 770 | 2001 |
Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis AM Caruso, N Serbina, E Klein, K Triebold, BR Bloom, JAL Flynn The Journal of Immunology 162 (9), 5407-5416, 1999 | 761 | 1999 |
Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology VP Mohan, CA Scanga, K Yu, HM Scott, KE Tanaka, E Tsang, MC Tsai, ... Infection and immunity 69 (3), 1847-1855, 2001 | 751 | 2001 |
Tuberculosis: what we don’t know can, and does, hurt us DG Russell, CE Barry 3rd, JAL Flynn Science 328 (5980), 852-856, 2010 | 707 | 2010 |
Understanding latent tuberculosis: a moving target PL Lin, JAL Flynn The Journal of Immunology 185 (1), 15-22, 2010 | 669 | 2010 |
Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection SV Capuano III, DA Croix, S Pawar, A Zinovik, A Myers, PL Lin, S Bissel, ... Infection and immunity 71 (10), 5831-5844, 2003 | 607 | 2003 |
Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection JAM Tufariello, J Chan, JAL Flynn The Lancet infectious diseases 3 (9), 578-590, 2003 | 601 | 2003 |
Activation of human dendritic cells following infection with Mycobacterium tuberculosis. RA Henderson, SC Watkins, JL Flynn Journal of immunology (Baltimore, Md.: 1950) 159 (2), 635-643, 1997 | 601 | 1997 |
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing PL Lin, CB Ford, MT Coleman, AJ Myers, R Gawande, T Ioerger, ... Nature medicine 20 (1), 75-79, 2014 | 582 | 2014 |
Prevention of tuberculosis in macaques after intravenous BCG immunization PA Darrah, JJ Zeppa, P Maiello, JA Hackney, MH Wadsworth, TK Hughes, ... Nature 577 (7788), 95-102, 2020 | 564 | 2020 |
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis J Chan, K Tanaka, D Carroll, J Flynn, BR Bloom Infection and immunity 63 (2), 736-740, 1995 | 559 | 1995 |
Macrophages and control of granulomatous inflammation in tuberculosis JL Flynn, J Chan, PL Lin Mucosal immunology 4 (3), 271-278, 2011 | 551 | 2011 |