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Sarah R Leist
Sarah R Leist
Potvrđena adresa e-pošte na ad.unc.edu
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Citirano
Citirano
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
TP Sheahan, AC Sims, SR Leist, A Schäfer, J Won, AJ Brown, ...
Nature communications 11 (1), 222, 2020
21312020
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
TP Sheahan, AC Sims, RL Graham, VD Menachery, LE Gralinski, ...
Science translational medicine 9 (396), eaal3653, 2017
19262017
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
KS Corbett, DK Edwards, SR Leist, OM Abiona, S Boyoglu-Barnum, ...
Nature 586 (7830), 567-571, 2020
16282020
SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract
YJ Hou, K Okuda, CE Edwards, DR Martinez, T Asakura, KH Dinnon, ...
Cell 182 (2), 429-446. e14, 2020
16142020
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
TP Sheahan, AC Sims, S Zhou, RL Graham, AJ Pruijssers, ML Agostini, ...
Science translational medicine 12 (541), eabb5883, 2020
11482020
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
YJ Hou, S Chiba, P Halfmann, C Ehre, M Kuroda, KH Dinnon III, SR Leist, ...
Science 370 (6523), 1464-1468, 2020
9772020
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
KH Dinnon III, SR Leist, A Schäfer, CE Edwards, DR Martinez, ...
Nature 586 (7830), 560-566, 2020
7302020
Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis
LE Gralinski, TP Sheahan, TE Morrison, VD Menachery, K Jensen, ...
MBio 9 (5), 10.1128/mbio. 01753-18, 2018
6152018
A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
SR Leist, KH Dinnon, A Schäfer, VT Longping, K Okuda, YJ Hou, A West, ...
Cell 183 (4), 1070-1085. e12, 2020
5962020
Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice
AJ Pruijssers, AS George, A Schäfer, SR Leist, LE Gralinksi, KH Dinnon, ...
Cell reports 32 (3), 2020
5262020
Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
AC Walls, B Fiala, A Schäfer, S Wrenn, MN Pham, M Murphy, ...
Cell 183 (5), 1367-1382. e17, 2020
5202020
SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova, KH Dinnon III, ...
Nature 591 (7850), 451-457, 2021
4132021
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
A Schäfer, F Muecksch, JCC Lorenzi, SR Leist, M Cipolla, S Bournazos, ...
Journal of Experimental Medicine 218 (3), e20201993, 2020
3422020
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
DR Martinez, A Schäfer, SR Leist, G De la Cruz, A West, ...
Science 373 (6558), 991-998, 2021
1852021
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
AC Walls, MC Miranda, A Schäfer, MN Pham, A Greaney, ...
Cell 184 (21), 5432-5447. e16, 2021
1692021
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020; 11 (1): 222
TP Sheahan, AC Sims, SR Leist, A Schäfer, J Won, AJ Brown, ...
Lancet 395, 1569-78, 2020
1662020
Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection
CE Edwards, BL Yount, RL Graham, SR Leist, YJ Hou, KH Dinnon III, ...
Proceedings of the National Academy of Sciences 117 (43), 26915-26925, 2020
1392020
High potency of a bivalent human VH domain in SARS-CoV-2 animal models
W Li, A Schäfer, SS Kulkarni, X Liu, DR Martinez, C Chen, Z Sun, SR Leist, ...
Cell 183 (2), 429-441. e16, 2020
1282020
Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate
W Sun, SR Leist, S McCroskery, Y Liu, S Slamanig, J Oliva, F Amanat, ...
EBioMedicine 62, 2020
1142020
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge
AT DiPiazza, SR Leist, OM Abiona, JI Moliva, A Werner, M Minai, ...
Immunity 54 (8), 1869-1882. e6, 2021
942021
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