| DNA damage is able to induce senescence in tumor cells in vitro and in vivo RH te Poele, AL Okorokov, L Jardine, J Cummings, SP Joel Cancer research 62 (6), 1876-1883, 2002 | 854 | 2002 |
| Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A E Bochkareva, L Kaustov, A Ayed, GS Yi, Y Lu, A Pineda-Lucena, ... Proceedings of the National Academy of Sciences 102 (43), 15412-15417, 2005 | 334 | 2005 |
| The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity AL Okorokov, MB Sherman, C Plisson, V Grinkevich, K Sigmundsson, ... The EMBO journal 25 (21), 5191-5200, 2006 | 157 | 2006 |
| Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity AM Habib, AL Okorokov, MN Hill, JT Bras, MC Lee, S Li, SJ Gossage, ... British journal of anaesthesia 123 (2), e249-e253, 2019 | 127 | 2019 |
| Structural biology of the p53 tumour suppressor AL Okorokov, EV Orlova Current opinion in structural biology 19 (2), 197-202, 2009 | 98 | 2009 |
| Induced N‐and C‐terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N‐terminus of full‐length p53, whereas … AL Okorokov, F Ponchel, J Milner The EMBO journal, 1997 | 86 | 1997 |
| RNA synthesis block by 5, 6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells RH te Poele, AL Okorokov, SP Joel Oncogene 18 (42), 5765-5772, 1999 | 82 | 1999 |
| Human topoisomerase IIα and IIβ interact with the C-terminal region of p53 IG Cowell, AL Okorokov, SA Cutts, K Padget, M Bell, J Milner, CA Austin Experimental cell research 255 (1), 86-94, 2000 | 76 | 2000 |
| The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage AL Okorokov, CP Rubbi, S Metcalfe, J Milner Oncogene 21 (3), 356-367, 2002 | 75 | 2002 |
| p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress M Jiang, T Axe, R Holgate, CP Rubbi, AL Okorokov, T Mee, J Milner Oncogene 20 (39), 5449-5458, 2001 | 68 | 2001 |
| Discovery of novel isatin-based p53 inducers P Davidovich, V Aksenova, V Petrova, D Tentler, D Orlova, S Smirnov, ... ACS Medicinal Chemistry Letters 6 (8), 856-860, 2015 | 61 | 2015 |
| Wild-type p53 protein shows calcium-dependent binding to F-actin S Metcalfe, A Weeds, AL Okorokov, J Milner, M Cockman, B Pope Oncogene 18 (14), 2351-2355, 1999 | 60 | 1999 |
| An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes AL Okorokov, J Milner Molecular and cellular biology 19 (11), 7501-7510, 1999 | 57 | 1999 |
| Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance R Aramayo, MB Sherman, K Brownless, R Lurz, AL Okorokov, EV Orlova Nucleic acids research 39 (20), 8960-8971, 2011 | 56 | 2011 |
| Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40 kDa and 35 kDa fragments competent for sequence-specific DNA binding. M Molinari, AL Okorokov, J Milner Oncogene 13 (10), 2077-2086, 1996 | 55 | 1996 |
| A novel human pain insensitivity disorder caused by a point mutation in ZFHX2 AM Habib, A Matsuyama, AL Okorokov, S Santana-Varela, JT Bras, ... Brain 141 (2), 365-376, 2018 | 54 | 2018 |
| The microRNA and p53 families join forces against cancer NA Barlev, BS Sayan, E Candi, AL Okorokov Cell Death & Differentiation 17 (2), 373-375, 2010 | 54 | 2010 |
| Hexameric ring structure of human MCM10 DNA replication factor AL Okorokov, A Waugh, J Hodgkinson, A Murthy, HK Hong, E Leo, ... EMBO reports 8 (10), 925-930, 2007 | 52 | 2007 |
| Molecular structure of human geminin AL Okorokov, EV Orlova, SR Kingsbury, C Bagneris, U Gohlke, ... Nature structural & molecular biology 11 (10), 1021-1022, 2004 | 50 | 2004 |
| Two p53 tetramers bind one consensus DNA response element S Kearns, R Lurz, EV Orlova, AL Okorokov Nucleic acids research 44 (13), 6185-6199, 2016 | 43 | 2016 |