Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction Y Sohtome, A Tanatani, Y Hashimoto, K Nagasawa Tetrahedron Letters 45 (29), 5589-5592, 2004 | 393 | 2004 |
Guanidine‐thiourea bifunctional organocatalyst for the asymmetric Henry (nitroaldol) reaction Y Sohtome, Y Hashimoto, K Nagasawa Advanced Synthesis & Catalysis 347 (11‐13), 1643-1648, 2005 | 298 | 2005 |
C2-symmetric chiral pentacyclic guanidine: A phase-transfer catalyst for the asymmetric alkylation of tert-butyl glycinate Schiff base T Kita, A Georgieva, Y Hashimoto, T Nakata, K Nagasawa Angewandte Chemie International Edition 41 (15), 2832-2834, 2002 | 225 | 2002 |
Total synthesis of pinnatoxin A JA McCauley, K Nagasawa, PA Lander, SG Mischke, MA Semones, ... Journal of the American Chemical Society 120 (30), 7647-7648, 1998 | 217 | 1998 |
Solution structure of an intramolecular (3+ 1) human telomeric G-quadruplex bound to a telomestatin derivative WJ Chung, B Heddi, M Tera, K Iida, K Nagasawa, AT Phan Journal of the American Chemical Society 135 (36), 13495-13501, 2013 | 201 | 2013 |
Solvent-dependent enantiodivergent Mannich-type reaction: utilizing a conformationally flexible guanidine/bisthiourea organocatalyst. Y Sohtome, S Tanaka, K Takada, T Yamaguchi, K Nagasawa Angewandte Chemie 122 (48), 9440-9443, 2010 | 164 | 2010 |
Entropy-Controlled Catalytic Asymmetric 1, 4-Type Friedel–Crafts Reaction of Phenols Using Conformationally Flexible Guanidine/Bisthiourea Organocatalyst Y Sohtome, B Shin, N Horitsugi, R Takagi, K Noguchi, K Nagasawa Angew. Chem. Int. Ed 49, 7299-7303, 2010 | 164 | 2010 |
Rif1 binds to G quadruplexes and suppresses replication over long distances Y Kanoh, S Matsumoto, R Fukatsu, N Kakusho, N Kono, C Renard-Guillet, ... Nature structural & molecular biology 22 (11), 889-897, 2015 | 163 | 2015 |
A nonclassical vitamin D receptor pathway suppresses renal fibrosis I Ito, T Waku, M Aoki, R Abe, Y Nagai, T Watanabe, Y Nakajima, I Ohkido, ... The Journal of clinical investigation 123 (11), 4579-4594, 2013 | 161 | 2013 |
Organocatalytic asymmetric nitroaldol reaction: Cooperative effects of guanidine and thiourea functional groups Y Sohtome, N Takemura, K Takada, R Takagi, T Iguchi, K Nagasawa Chemistry–An Asian Journal 2 (9), 1150-1160, 2007 | 154 | 2007 |
Macrocyclic hexaoxazoles as sequence‐and mode‐selective G‐quadruplex binders M Tera, H Ishizuka, M Takagi, M Suganuma, K Shin‐ya, K Nagasawa Angewandte Chemie International Edition 47 (30), 5557-5560, 2008 | 148 | 2008 |
A novel glucosylation reaction on anthocyanins catalyzed by acyl-glucose–dependent glucosyltransferase in the petals of carnation and delphinium Y Matsuba, N Sasaki, M Tera, M Okamura, Y Abe, E Okamoto, ... The Plant Cell 22 (10), 3374-3389, 2010 | 140 | 2010 |
Vitamin D metabolite, 25-hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP L Asano, M Watanabe, Y Ryoden, K Usuda, T Yamaguchi, B Khambu, ... Cell chemical biology 24 (2), 207-217, 2017 | 139 | 2017 |
Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety T Ishioka, A Kubo, Y Koiso, K Nagasawa, A Itai, Y Hashimoto Bioorganic & medicinal chemistry 10 (5), 1555-1566, 2002 | 128 | 2002 |
Diastereoselective and enantioselective Henry (nitroaldol) reaction utilizing a guanidine‐thiourea bifunctional organocatalyst Y Sohtome, Y Hashimoto, K Nagasawa European journal of organic chemistry 2006 (13), 2894-2897, 2006 | 122 | 2006 |
Ligand-induced conformational changes with cation ejection upon binding to human telomeric DNA G-quadruplexes A Marchand, A Granzhan, K Iida, Y Tsushima, Y Ma, K Nagasawa, ... Journal of the American Chemical Society 137 (2), 750-756, 2015 | 121 | 2015 |
Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells S Hirose, N Takayama, S Nakamura, K Nagasawa, K Ochi, S Hirata, ... Stem cell reports 1 (6), 499-508, 2013 | 118 | 2013 |
Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor T Ishioka, A Tanatani, K Nagasawa, Y Hashimoto Bioorganic & medicinal chemistry letters 13 (16), 2655-2658, 2003 | 110 | 2003 |
Topologies of G-quadruplex: Biological functions and regulation by ligands Y Ma, K Iida, K Nagasawa Biochemical and biophysical research communications 531 (1), 3-17, 2020 | 106 | 2020 |
Thiourea-catalyzed Morita–Baylis–Hillman reaction Y Sohtome, N Takemura, R Takagi, Y Hashimoto, K Nagasawa Tetrahedron 64 (40), 9423-9429, 2008 | 104 | 2008 |